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Guido Ferrari, MD

Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Friedman, James, S Munir Alam, Xiaoying Shen, Shi-Mao Xia, Shelley Stewart, Kara Anasti, Justin Pollara, et al. “Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum.” Plos One 7, no. 5 (2012): e37648. https://doi.org/10.1371/journal.pone.0037648.

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Ferrari, G., J. Cox, A. Garcia, W. Rountree, C. DeCastro, R. Louzao, B. Liebl, et al. “Development of CAVD/EQAPOL Long-Term PBMC Repository ('07-'10) @ DUMC; T-Cell Functionality as Measured by ELISpot and Flow Cytometry Is Maintained Ov.” In Aids Research and Human Retroviruses, 27:A55–A55. MARY ANN LIEBERT INC, 2011.

Scholars@Duke

Franchini, G., M. Vaccari, B. Keele, M. Doster, Z. Ma, A. Hryniewicz, T. Morgan, et al. “Efficacy of HIV Vaccine Candidate in Macaques Dependent on the Dose of SIVmac251 Challenge Exposure: Immune Correlates of Vaccine Efficacy.” In Aids Research and Human Retroviruses, 27:A111–A111. MARY ANN LIEBERT INC, 2011.

Scholars@Duke

Ganusov, Vitaly V., Nilu Goonetilleke, Michael K. P. Liu, Guido Ferrari, George M. Shaw, Andrew J. McMichael, Persephone Borrow, Bette T. Korber, and Alan S. Perelson. “Fitness costs and diversity of the cytotoxic T lymphocyte (CTL) response determine the rate of CTL escape during acute and chronic phases of HIV infection.” J Virol 85, no. 20 (October 2011): 10518–28. https://doi.org/10.1128/JVI.00655-11.

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Fouda, G., N. Yates, J. Pollara, G. Overman, T. Mahlokozera, A. Wilks, H. Kang, et al. “HIV Neutralization in Breast Milk Mirrors that of Plasma and Is Mainly Mediated by IgG Antibodies.” In Aids Research and Human Retroviruses, 27:A72–A72. MARY ANN LIEBERT INC, 2011.

Scholars@Duke

Ferrari, G., J. Pollara, D. Kozink, T. Harms, M. Drinker, S. Freel, M. A. Moody, et al. “Mapping of ADCC Activity: The A32 Conformational C1 Epitope is a Dominant Target for ADCC Antibodies in Chronically HIV-1 Infected Subjects.” In Aids Research and Human Retroviruses, 27:A66–A66. MARY ANN LIEBERT INC, 2011.

Scholars@Duke

Freel, S. A., R. A. Picking, G. Ferrari, C. Ochsenbauer, J. C. Kappes, J. Kirchherr, K. J. Weinhold, et al. “Ontogeny of CD8+T Cells in Acute HIV-1 that Inhibit Autologous and Heterologous Transmitted/Founder (T/F) Viruses.” In Aids Research and Human Retroviruses, 27:A13–A13. MARY ANN LIEBERT INC, 2011.

Scholars@Duke

Pollara, J., L. Morris, N. Meguid, J. Pickeral, J. Hoxie, J. Kappes, C. Ochsenbauer, et al. “Ontogeny, Breadth, and Specificity of Circulating ADCC-Mediating Antibodies in HIV-1 Infected Individuals.” In Aids Research and Human Retroviruses, 27:A66–67. MARY ANN LIEBERT INC, 2011.

Scholars@Duke

Franchini, G., P. Pegu, M. Vaccari, S. Gordon, B. Keele, M. Doster, Y. Guan, et al. “Titered Mucosal Challenge of Rhesus Macaques with SIVmac251 Recapitulates HIV Vaccine Efficacy in Humans.” In Aids Research and Human Retroviruses, 27:A4–A4. MARY ANN LIEBERT INC, 2011.

Scholars@Duke

Fouda, Genevieve G., Nicole L. Yates, Justin Pollara, Xiaoying Shen, Glenn R. Overman, Tatenda Mahlokozera, Andrew B. Wilks, et al. “HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies.” J Virol 85, no. 18 (September 2011): 9555–67. https://doi.org/10.1128/JVI.05174-11.

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