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Guido Ferrari, MD

Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Ferrari, Guido, Bette Korber, Nilu Goonetilleke, Michael K. P. Liu, Emma L. Turnbull, Jesus F. Salazar-Gonzalez, Natalie Hawkins, et al. “Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection..” Plos Pathog 7, no. 2 (February 10, 2011). https://doi.org/10.1371/journal.ppat.1001273.

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Weinberg, Adriana, Lin Ye Song, Cindy L. Wilkening, Terry Fenton, John Hural, Raul Louzao, Guido Ferrari, et al. “Optimization of storage and shipment of cryopreserved peripheral blood mononuclear cells from HIV-infected and uninfected individuals for ELISPOT assays..” J Immunol Methods 363, no. 1 (December 15, 2010): 42–50. https://doi.org/10.1016/j.jim.2010.09.032.

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Pollara, J., G. Landucci, C. Trac, C. White, N. Yates, J. Kappes, C. Ochsenbauer, et al. “Early Appearance of ADCC- and ADCVI-mediating Antibody Responses Against Autologous HIV-1 Transmitted/Founder Virus.” In Aids Research and Human Retroviruses, 26:A12–A12. MARY ANN LIEBERT INC, 2010.

Scholars@Duke

Ferrari, G., B. Korber, E. Turnbull, M. K. Liu, N. Goonetilleke, J. Salazar, M. Betts, et al. “High magnitude and multifunctionality epitope-specific CD8+T-cell responses are associated are associated with selection of escape mutants in acute HIV infection.” In Aids Research and Human Retroviruses, 26:A5–6. MARY ANN LIEBERT INC, 2010.

Scholars@Duke

Pollara, J., L. Hart, J. Hoxie, J. Kappes, C. Ochsenbauer, L. Morris, K. Soderberg, et al. “High titers of cross-clade ADCC-mediating antibodies are detectable in plasma samples collected from individuals with broadly neutralizing antibodies.” In Aids Research and Human Retroviruses, 26:A20–21. MARY ANN LIEBERT INC, 2010.

Scholars@Duke

Yates, N., X. Shen, P. Liu, S. Barnett, P. Spearman, S. Lu, G. Ferrari, et al. “Vaccine-Elicited IgG Subclasses and Functional Antibodies.” In Aids Research and Human Retroviruses, 26:A157–A157. MARY ANN LIEBERT INC, 2010.

Scholars@Duke

Graham, Barney S., M Juliana McElrath, Michael C. Keefer, Kyle Rybczyk, David Berger, Kent J. Weinhold, Janet Ottinger, et al. “Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity..” Plos One 5, no. 8 (August 10, 2010). https://doi.org/10.1371/journal.pone.0011995.

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Freel, Stephanie A., Laurie Lamoreaux, Pratip K. Chattopadhyay, Kevin Saunders, David Zarkowsky, R Glenn Overman, Christina Ochsenbauer, et al. “Phenotypic and functional profile of HIV-inhibitory CD8 T cells elicited by natural infection and heterologous prime/boost vaccination..” J Virol 84, no. 10 (May 2010): 4998–5006. https://doi.org/10.1128/JVI.00138-10.

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Cella, Marina, Rachel Presti, William Vermi, Kerry Lavender, Emma Turnbull, Christina Ochsenbauer-Jambor, John C. Kappes, et al. “Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection..” European Journal of Immunology 40, no. 4 (April 2010): 949–54. https://doi.org/10.1002/eji.200940234.

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Janetzki, Sylvia, L. Price, C. M. Britten, S. H. van der Burg, J. Caterini, J. R. Currier, G. Ferrari, et al. “Performance of serum-supplemented and serum-free media in IFNgamma Elispot Assays for human T cells..” Cancer Immunol Immunother 59, no. 4 (April 2010): 609–18. https://doi.org/10.1007/s00262-009-0788-2.

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