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Guido Ferrari, MD

Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Fouda, Genevieve G., Nicole L. Yates, Justin Pollara, Xiaoying Shen, Glenn R. Overman, Tatenda Mahlokozera, Andrew B. Wilks, et al. “HIV-specific functional antibody responses in breast milk mirror those in plasma and are primarily mediated by IgG antibodies..” J Virol 85, no. 18 (September 2011): 9555–67. https://doi.org/10.1128/JVI.05174-11.

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Pollara, Justin, Lydia Hart, Faraha Brewer, Joy Pickeral, Beverly Z. Packard, James A. Hoxie, Akira Komoriya, et al. “High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses..” Cytometry A 79, no. 8 (August 2011): 603–12. https://doi.org/10.1002/cyto.a.21084.

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Ferrari, Guido, Justin Pollara, Daniel Kozink, Tiara Harms, Mark Drinker, Stephanie Freel, M Anthony Moody, et al. “An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum..” J Virol 85, no. 14 (July 2011): 7029–36. https://doi.org/10.1128/JVI.00171-11.

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Lai, Lilin, Suefen Kwa, Pamela A. Kozlowski, David C. Montefiori, Guido Ferrari, Welkin E. Johnson, Vanessa Hirsch, et al. “Prevention of infection by a granulocyte-macrophage colony-stimulating factor co-expressing DNA/modified vaccinia Ankara simian immunodeficiency virus vaccine..” J Infect Dis 204, no. 1 (July 1, 2011): 164–73. https://doi.org/10.1093/infdis/jir199.

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Gay, Cynthia, Oliver Dibben, Jeffrey A. Anderson, Andrea Stacey, Ashley J. Mayo, Philip J. Norris, JoAnn D. Kuruc, et al. “Cross-sectional detection of acute HIV infection: timing of transmission, inflammation and antiretroviral therapy..” Plos One 6, no. 5 (May 10, 2011). https://doi.org/10.1371/journal.pone.0019617.

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Yamamoto, Takuya, David A. Price, Joseph P. Casazza, Guido Ferrari, Martha Nason, Pratip K. Chattopadhyay, Mario Roederer, et al. “Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection..” Blood 117, no. 18 (May 5, 2011): 4805–15. https://doi.org/10.1182/blood-2010-11-317297.

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Frahm, Marc, Neela D. Goswami, Kouros Owzar, Emily Hecker, Ann Mosher, Emily Cadogan, Payam Nahid, Guido Ferrari, and Jason E. Stout. “Discriminating between latent and active tuberculosis with multiple biomarker responses..” Tuberculosis (Edinb) 91, no. 3 (May 2011): 250–56. https://doi.org/10.1016/j.tube.2011.02.006.

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Gay, Cynthia L., Ashley J. Mayo, Chelu K. Mfalila, Haitao Chu, Anna C. Barry, JoAnn D. Kuruc, Kara S. McGee, et al. “Efficacy of NNRTI-based antiretroviral therapy initiated during acute HIV infection..” Aids 25, no. 7 (April 24, 2011): 941–49. https://doi.org/10.1097/QAD.0b013e3283463c07.

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Ganusov, Vitaly, Nilu Goonetilleke, Michael Liu, Guido Ferrari, George Shaw, Andrew McMichael, Persephone Borrow, Bette Korber, and Alan Perelson. “Fitness costs and diversity of CTL response determine the rate of CTL escape during the acute and chronic phases of HIV infection.” Journal of Immunology 186 (April 1, 2011).

Scholars@Duke

Keefer, Michael C., Sharon E. Frey, Marnie Elizaga, Barbara Metch, Stephen C. De Rosa, Paulo F. Barroso, Georgia Tomaras, et al. “A phase I trial of preventive HIV vaccination with heterologous poxviral-vectors containing matching HIV-1 inserts in healthy HIV-uninfected subjects..” Vaccine 29, no. 10 (February 24, 2011): 1948–58. https://doi.org/10.1016/j.vaccine.2010.12.104.

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