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Guido Ferrari, MD

Guido Ferrari, MD
Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Haynes, Barton F., Peter B. Gilbert, M Juliana McElrath, Susan Zolla-Pazner, Georgia D. Tomaras, S Munir Alam, David T. Evans, et al. “Immune-correlates analysis of an HIV-1 vaccine efficacy trial.” N Engl J Med 366, no. 14 (April 5, 2012): 1275–86. https://doi.org/10.1056/NEJMoa1113425.

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Riou, Catherine, Vitaly V. Ganusov, Suzanne Campion, Mandla Mlotshwa, Michael K. P. Liu, Victoria E. Whale, Nilu Goonetilleke, et al. “Distinct kinetics of Gag-specific CD4+ and CD8+ T cell responses during acute HIV-1 infection.” Journal of Immunology (Baltimore, Md. : 1950) 188, no. 5 (March 2012): 2198–2206. https://doi.org/10.4049/jimmunol.1102813.

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Cox, Josephine H., Maria G. Ferrari, Patricia Earl, James R. Lane, Linda L. Jagodzinski, Victoria R. Polonis, Ellen G. Kuta, et al. “Inclusion of a CRF01_AE HIV envelope protein boost with a DNA/MVA prime-boost vaccine: Impact on humoral and cellular immunogenicity and viral load reduction after SHIV-E challenge.” Vaccine 30, no. 10 (February 27, 2012): 1830–40. https://doi.org/10.1016/j.vaccine.2011.12.131.

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Lai, Lilin, Sue-Fen Kwa, Pamela A. Kozlowski, David C. Montefiori, Tracy L. Nolen, Michael G. Hudgens, Welkin E. Johnson, et al. “SIVmac239 MVA vaccine with and without a DNA prime, similar prevention of infection by a repeated dose SIVsmE660 challenge despite different immune responses.” Vaccine 30, no. 9 (February 21, 2012): 1737–45. https://doi.org/10.1016/j.vaccine.2011.12.026.

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Barouch, Dan H., Jinyan Liu, Hualin Li, Lori F. Maxfield, Peter Abbink, Diana M. Lynch, M Justin Iampietro, et al. “Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys.” Nature 482, no. 7383 (January 4, 2012): 89–93. https://doi.org/10.1038/nature10766.

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Hutnick, N. A., M. Karuppiah, J. Pollara, J. Yan, D. J. Myles, K. Broderick, M. Morrow, et al. “E-DNA IM or ID delivery prime enhances antibody and T cell responses following recombinant gp120 env boost.” In Retrovirology, 9:P364–P364. Springer Science and Business Media LLC, 2012. https://doi.org/10.1186/1742-4690-9-s2-p364.

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Friedman, James, S Munir Alam, Xiaoying Shen, Shi-Mao Xia, Shelley Stewart, Kara Anasti, Justin Pollara, et al. “Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum.” Plos One 7, no. 5 (2012): e37648. https://doi.org/10.1371/journal.pone.0037648.

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Ferrari, G., J. Cox, A. Garcia, W. Rountree, C. DeCastro, R. Louzao, B. Liebl, et al. “Development of CAVD/EQAPOL Long-Term PBMC Repository ('07-'10) @ DUMC; T-Cell Functionality as Measured by ELISpot and Flow Cytometry Is Maintained Ov.” In Aids Research and Human Retroviruses, 27:A55–A55. MARY ANN LIEBERT INC, 2011.

Scholars@Duke

Franchini, G., M. Vaccari, B. Keele, M. Doster, Z. Ma, A. Hryniewicz, T. Morgan, et al. “Efficacy of HIV Vaccine Candidate in Macaques Dependent on the Dose of SIVmac251 Challenge Exposure: Immune Correlates of Vaccine Efficacy.” In Aids Research and Human Retroviruses, 27:A111–A111. MARY ANN LIEBERT INC, 2011.

Scholars@Duke

Ganusov, Vitaly V., Nilu Goonetilleke, Michael K. P. Liu, Guido Ferrari, George M. Shaw, Andrew J. McMichael, Persephone Borrow, Bette T. Korber, and Alan S. Perelson. “Fitness costs and diversity of the cytotoxic T lymphocyte (CTL) response determine the rate of CTL escape during acute and chronic phases of HIV infection.” J Virol 85, no. 20 (October 2011): 10518–28. https://doi.org/10.1128/JVI.00655-11.

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