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Guido Ferrari, MD

Guido Ferrari, MD
Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Bonsignori, M., J. Pollara, M. A. Moody, T. B. Kepler, X. Chen, T. C. Gurley, D. M. Kozink, et al. “Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial preferentially use the VH1 gene family.” In Retrovirology, Vol. 9. Springer Science and Business Media LLC, 2012. https://doi.org/10.1186/1742-4690-9-s2-p78.

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Joachim, A., C. Nilsson, S. Aboud, E. F. Lyamuya, M. Robb, M. Marovich, C. Ochsenbauer, et al. “Antibody-mediated inhibition of HIV-1 elicited by HIV-I DNA priming and boosting with heterologous HIV-1 recombinant MVA in healthy Tanzanian adults.” In Retrovirology, Vol. 9. Springer Science and Business Media LLC, 2012. https://doi.org/10.1186/1742-4690-9-s2-o53.

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Williams, W. B., K. Jones, A. Krambrink, D. Grove, P. Liu, N. L. Yates, M. A. Moody, et al. “Multiple antibody specificities (gp41, V1V2, and V3) elicited in the phase II multiclade (A, B, C) HIV-1 DNA prime, rAd5 boost vaccine trial.” In Retrovirology, Vol. 9. Springer Science and Business Media LLC, 2012. https://doi.org/10.1186/1742-4690-9-s2-o55.

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Pollara, J., M. Bonsignori, M. Moody, M. Alam, H. Liao, K. Hwang, J. Pickeral, et al. “Vaccine-induced ADCC-mediating antibodies target unique and overlapping envelope epitopes.” In Retrovirology, Vol. 9. Springer Science and Business Media LLC, 2012. https://doi.org/10.1186/1742-4690-9-s2-o39.

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Arnoczy, Gretchen S., Guido Ferrari, Nilu Goonetilleke, Tumena Corrah, Hui Li, Joann Kuruc, John L. Schmitz, et al. “Massive CD8 T cell response to primary HIV infection in the setting of severe clinical presentation.” Aids Res Hum Retroviruses 28, no. 8 (August 2012): 789–92. https://doi.org/10.1089/AID.2011.0145.

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Britten, C. M., S. Janetzki, L. H. Butterfield, G. Ferrari, C. Gouttefangeas, C. Huber, M. Kalos, et al. “T cell assays and MIATA: the essential minimum for maximum impact.” Immunity 37, no. 1 (July 27, 2012): 1–2. https://doi.org/10.1016/j.immuni.2012.07.010.

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Moody, M Anthony, Nicole L. Yates, Joshua D. Amos, Mark S. Drinker, Joshua A. Eudailey, Thaddeus C. Gurley, Dawn J. Marshall, et al. “HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineages.” J Virol 86, no. 14 (July 2012): 7496–7507. https://doi.org/10.1128/JVI.00426-12.

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Frahm, M. A., G. D. Tomaras, and G. Ferrari. “Response to comment on "CD4 +CD8 + T cells represent a significant portion of the anti-HIV T cell response to acute HIV infection".” Journal of Immunology, June 15, 2012. https://doi.org/10.4049/jimmunol.1290029.

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Freel, Stephanie A., Ralph A. Picking, Guido Ferrari, Haitao Ding, Christina Ochsenbauer, John C. Kappes, Jennifer L. Kirchherr, et al. “Initial HIV-1 antigen-specific CD8+ T cells in acute HIV-1 infection inhibit transmitted/founder virus replication.” J Virol 86, no. 12 (June 2012): 6835–46. https://doi.org/10.1128/JVI.00437-12.

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Frahm, Marc A., Ralph A. Picking, JoAnn D. Kuruc, Kara S. McGee, Cynthia L. Gay, Joseph J. Eron, Charles B. Hicks, Georgia D. Tomaras, and Guido Ferrari. “CD4+CD8+ T cells represent a significant portion of the anti-HIV T cell response to acute HIV infection.” J Immunol 188, no. 9 (May 1, 2012): 4289–96. https://doi.org/10.4049/jimmunol.1103701.

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