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Guido Ferrari, MD

Guido Ferrari, MD
Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Pegu, Poonam, Monica Vaccari, Shari Gordon, Brandon F. Keele, Melvin Doster, Yongjun Guan, Guido Ferrari, et al. “Antibodies with high avidity to the gp120 envelope protein in protection from simian immunodeficiency virus SIV(mac251) acquisition in an immunization regimen that mimics the RV-144 Thai trial.” J Virol 87, no. 3 (February 2013): 1708–19. https://doi.org/10.1128/JVI.02544-12.

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Liao, Hua-Xin, Mattia Bonsignori, S Munir Alam, Jason S. McLellan, Georgia D. Tomaras, M Anthony Moody, Daniel M. Kozink, et al. “Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2.” Immunity 38, no. 1 (January 24, 2013): 176–86. https://doi.org/10.1016/j.immuni.2012.11.011.

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McKellar, Mehri S., Anna B. Cope, Cynthia L. Gay, Kara S. McGee, Joann D. Kuruc, Melissa G. Kerkau, Christopher B. Hurt, et al. “Acute HIV-1 infection in the Southeastern United States: a cohort study.” Aids Res Hum Retroviruses 29, no. 1 (January 2013): 121–28. https://doi.org/10.1089/aid.2012.0064.

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Weaver, Eric A., Pramod N. Nehete, Bharti P. Nehete, Guojun Yang, Stephanie J. Buchl, Patrick W. Hanley, Donna Palmer, et al. “Comparison of systemic and mucosal immunization with helper-dependent adenoviruses for vaccination against mucosal challenge with SHIV.” Plos One 8, no. 7 (2013): e67574. https://doi.org/10.1371/journal.pone.0067574.

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Lambotte, Olivier, Justin Pollara, Faroudy Boufassa, Christiane Moog, Alain Venet, Barton F. Haynes, Jean-François Delfraissy, Asier Saez-Cirion, and Guido Ferrari. “High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers.” Plos One 8, no. 9 (2013): e74855. https://doi.org/10.1371/journal.pone.0074855.

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Liu, Michael K. P., Natalie Hawkins, Adam J. Ritchie, Vitaly V. Ganusov, Victoria Whale, Simon Brackenridge, Hui Li, et al. “Vertical T cell immunodominance and epitope entropy determine HIV-1 escape.” J Clin Invest 123, no. 1 (January 2013): 380–93. https://doi.org/10.1172/JCI65330.

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Bonsignori, Mattia, Justin Pollara, M Anthony Moody, Michael D. Alpert, Xi Chen, Kwan-Ki Hwang, Peter B. Gilbert, et al. “Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family.” J Virol 86, no. 21 (November 2012): 11521–32. https://doi.org/10.1128/JVI.01023-12.

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Fukazawa, Yoshinori, Haesun Park, Mark J. Cameron, Francois Lefebvre, Richard Lum, Noel Coombes, Eisa Mahyari, et al. “Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines.” Nat Med 18, no. 11 (November 2012): 1673–81. https://doi.org/10.1038/nm.2934.

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Song, Hongshuo, Jeffrey W. Pavlicek, Fangping Cai, Tanmoy Bhattacharya, Hui Li, Shilpa S. Iyer, Katharine J. Bar, et al. “Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome.” Retrovirology 9 (October 30, 2012): 89. https://doi.org/10.1186/1742-4690-9-89.

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Franchini, G., P. Pegu, S. Gordon, B. Keele, M. Doster, Y. Guan, G. Ferrari, et al. “Antibodies to the envelope protein protect macaques from SIVmac251 acquisition in an immunization regimen that mimics the RV-144 Thai trial.” In Retrovirology, Vol. 9. Springer Science and Business Media LLC, 2012. https://doi.org/10.1186/1742-4690-9-s2-o2.

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