Skip to main content

Search form

You are here

Guido Ferrari, MD

Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Division: 
Surgical Sciences
Faculty Lab: 
Innate and Adaptive Cellular Cytotoxicity Laboratory
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Wills, S, Hwang, K-K, Liu, P, Dennison, SM, Tay, MZ, Shen, X, Pollara, J, Lucas, JT, Parks, R, Rerks-Ngarm, S, Pitisuttithum, P, Nitayapan, S, Kaewkungwal, J, Thomas, R, Kim, JH, Michael, NL, Robb, ML, McRaven, M, Montefiori, DC, Hope, TJ, Liao, H-X, Moody, MA, Ferrari, G, Haynes, BF, Alam, SM, Bonsignori, M, and Tomaras, GD. "HIV-1-Specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galactosylceramide Blocking and Phagocytosis." Journal of virology 92, no. 7 (April 2018).

Full Text

Saunders, KO, Santra, S, Parks, R, Yates, NL, Sutherland, LL, Scearce, RM, Balachandran, H, Bradley, T, Goodman, D, Eaton, A, Stanfield-Oakley, SA, Tartaglia, J, Phogat, S, Pantaleo, G, Esteban, M, Gomez, CE, Perdiguero, B, Jacobs, B, Kibler, K, Korber, B, Montefiori, DC, Ferrari, G, Vandergrift, N, Liao, H-X, Tomaras, GD, and Haynes, BF. "Immunogenicity of NYVAC Prime-Protein Boost Human Immunodeficiency Virus Type 1 Envelope Vaccination and Simian-Human Immunodeficiency Virus Challenge of Nonhuman Primates." Journal of virology 92, no. 8 (April 2018).

Full Text

Garrido, C, Abad-Fernandez, M, Tuyishime, M, Pollara, JJ, Ferrari, G, Soriano-Sarabia, N, and Margolis, DM. "IL-15 STIMULATED NATURAL KILLER CELLS CLEAR HIV-1 INFECTED CELLS FOLLOWING LATENCY REVERSAL EX VIVO." Journal of virology (March 28, 2018).

Full Text

Pollara, J, Orlandi, C, Beck, C, Edwards, RW, Hu, Y, Liu, S, Wang, S, Koup, RA, Denny, TN, Lu, S, Tomaras, GD, DeVico, A, Lewis, GK, and Ferrari, G. "Application of area scaling analysis to identify natural killer cell and monocyte involvement in the GranToxiLux antibody dependent cell-mediated cytotoxicity assay." Cytometry. Part A : the journal of the International Society for Analytical Cytology (March 2, 2018).

Full Text

Jones, AT, Chamcha, V, Kesavardhana, S, Shen, X, Beaumont, D, Das, R, Wyatt, LS, LaBranche, CC, Stanfield-Oakley, S, Ferrari, G, Montefiori, DC, Moss, B, Tomaras, GD, Varadarajan, R, and Amara, RR. "A Trimeric HIV-1 Envelope gp120 Immunogen Induces Potent and Broad Anti-V1V2 Loop Antibodies against HIV-1 in Rabbits and Rhesus Macaques." Journal of virology 92, no. 5 (March 2018).

Full Text

Fong, Y, Shen, X, Ashley, VC, Deal, A, Seaton, KE, Yu, C, Grant, SP, Ferrari, G, deCamp, AC, Bailer, RT, Koup, RA, Montefiori, D, Haynes, BF, Sarzotti-Kelsoe, M, Graham, BS, Carpp, LN, Hammer, SM, Sobieszczyk, M, Karuna, S, Swann, E, DeJesus, E, Mulligan, M, Frank, I, Buchbinder, S, Novak, RM, McElrath, MJ, Kalams, S, Keefer, M, Frahm, NA, Janes, HE, Gilbert, PB, and Tomaras, GD. "Modification of the Association Between T-Cell Immune Responses and Human Immunodeficiency Virus Type 1 Infection Risk by Vaccine-Induced Antibody Responses in the HVTN 505 Trial." The Journal of infectious diseases 217, no. 8 (March 2018): 1280-1288.

Full Text

Eudailey, JA, Dennis, ML, Parker, ME, Phillips, BL, Huffman, TN, Bay, CP, Hudgens, MG, Wiseman, RW, Pollara, JJ, Fouda, GG, Ferrari, G, Pickup, DJ, Kozlowski, PA, Van Rompay, KKA, De Paris, K, and Permar, SR. "Maternal HIV-1 Env Vaccination for Systemic and Breast Milk Immunity To Prevent Oral SHIV Acquisition in Infant Macaques." mSphere 3, no. 1 (January 10, 2018).

Full Text

Shen, X, Basu, R, Sawant, S, Beaumont, D, Kwa, SF, LaBranche, C, Seaton, KE, Yates, NL, Montefiori, DC, Ferrari, G, Wyatt, LS, Moss, B, Alam, SM, Haynes, BF, Tomaras, GD, and Robinson, HL. "HIV-1 gp120 and Modified Vaccinia Virus Ankara (MVA) gp140 Boost Immunogens Increase Immunogenicity of a DNA/MVA HIV-1 Vaccine." Journal of virology 91, no. 24 (December 2017).

Full Text

Francica, JR, Zak, DE, Linde, C, Siena, E, Johnson, C, Juraska, M, Yates, NL, Gunn, B, De Gregorio, E, Flynn, BJ, Valiante, NM, Malyala, P, Barnett, SW, Sarkar, P, Singh, M, Jain, S, Ackerman, M, Alam, M, Ferrari, G, Tomaras, GD, O'Hagan, DT, Aderem, A, Alter, G, and Seder, RA. "Innate transcriptional effects by adjuvants on the magnitude, quality, and durability of HIV envelope responses in NHPs." Blood advances 1, no. 25 (November 17, 2017): 2329-2342.

Full Text

Mayer, KH, Seaton, KE, Huang, Y, Grunenberg, N, Isaacs, A, Allen, M, Ledgerwood, JE, Frank, I, Sobieszczyk, ME, Baden, LR, Rodriguez, B, Van Tieu, H, Tomaras, GD, Deal, A, Goodman, D, Bailer, RT, Ferrari, G, Jensen, R, Hural, J, Graham, BS, Mascola, JR, Corey, L, Montefiori, DC, HVTN 104 Protocol Team, , and and the NIAID HIV Vaccine Trials Network, . "Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adults: Results of a phase 1 randomized trial." PLoS medicine 14, no. 11 (November 14, 2017): e1002435-.

Full Text

Pages