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Guido Ferrari, MD

Guido Ferrari, MD
Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Division: 
Surgical Sciences
Faculty Lab: 
Innate and Adaptive Cellular Cytotoxicity Laboratory
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

In the News

Selected Grants

Publications

DeRosa, Stephen, Srilatha Edupuganti, Yunda Huang, Xue Han, Marnie Elizaga, Edith Swann, Laura Polakowski, et al. “Robust antibody and cellular responses induced by DNA-only vaccination for HIV.” Jci Insight, May 21, 2020. https://doi.org/10.1172/jci.insight.137079.

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Garrido, Carolina, Maria Abad-Fernandez, Marina Tuyishime, Justin J. Pollara, Guido Ferrari, Natalia Soriano-Sarabia, and David M. Margolis. “Correction for Garrido et al., "Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex Vivo".” J Virol 94, no. 11 (May 18, 2020). https://doi.org/10.1128/JVI.00223-20.

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Felber, Barbara K., Zhongyan Lu, Xintao Hu, Antonio Valentin, Margherita Rosati, Christopher A. L. Remmel, Joshua A. Weiner, et al. “Co-immunization of DNA and Protein in the Same Anatomical Sites Induces Superior Protective Immune Responses against SHIV Challenge.” Cell Rep 31, no. 6 (May 12, 2020): 107624. https://doi.org/10.1016/j.celrep.2020.107624.

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Margolis, David M., Nancie M. Archin, Myron S. Cohen, Joseph J. Eron, Guido Ferrari, J Victor Garcia, Cynthia L. Gay, et al. “Curing HIV: Seeking to Target and Clear Persistent Infection.” Cell 181, no. 1 (April 2, 2020): 189–206. https://doi.org/10.1016/j.cell.2020.03.005.

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Curtis, Alan D., Maria Dennis, Joshua Eudailey, Korey L. Walter, Kenneth Cronin, S Munir Alam, Neelima Choudhary, et al. “HIV Env-Specific IgG Antibodies Induced by Vaccination of Neonatal Rhesus Macaques Persist and Can Be Augmented by a Late Booster Immunization in Infancy.” Msphere 5, no. 2 (March 25, 2020). https://doi.org/10.1128/mSphere.00162-20.

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Wise, Megan C., Ziyang Xu, Edgar Tello-Ruiz, Charles Beck, Aspen Trautz, Ami Patel, Sarah Tc Elliott, et al. “In vivo delivery of synthetic DNA-encoded antibodies induces broad HIV-1-neutralizing activity.” J Clin Invest 130, no. 2 (February 3, 2020): 827–37. https://doi.org/10.1172/JCI132779.

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Chu, Thach H., Andrew R. Crowley, Iara Backes, Cheryl Chang, Matthew Tay, Thomas Broge, Marina Tuyishime, et al. “Hinge length contributes to the phagocytic activity of HIV-specific IgG1 and IgG3 antibodies.” Plos Pathog 16, no. 2 (February 2020): e1008083. https://doi.org/10.1371/journal.ppat.1008083.

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Easterhoff, David, Justin Pollara, Kan Luo, William D. Tolbert, Brianna Young, Dieter Mielke, Shalini Jha, et al. “Boosting with AIDSVAX B/E Enhances Env Constant Region 1 and 2 Antibody-Dependent Cellular Cytotoxicity Breadth and Potency.” J Virol 94, no. 4 (January 31, 2020). https://doi.org/10.1128/JVI.01120-19.

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Pollara, Justin, R Whitney Edwards, Shalini Jha, Chia-Ying Kao Lam, Liqin Liu, Gundo Diedrich, Jeffrey L. Nordstrom, et al. “Redirection of Cord Blood T Cells and Natural Killer Cells for Elimination of Autologous HIV-1-Infected Target Cells Using Bispecific DART® Molecules.” Front Immunol 11 (2020): 713. https://doi.org/10.3389/fimmu.2020.00713.

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Giel-Moloney, M., M. Esteban, B. H. Oakes, M. Vaine, B. Asbach, R. Wagner, G. J. Mize, et al. “Recombinant HIV-1 vaccine candidates based on replication-defective flavivirus vector.” Sci Rep 9, no. 1 (December 27, 2019): 20005. https://doi.org/10.1038/s41598-019-56550-4.

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