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Guido Ferrari, MD

Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Division: 
Surgical Sciences
Faculty Lab: 
Innate and Adaptive Cellular Cytotoxicity Laboratory
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

In the News

Selected Grants

Publications

Pollara, J, Jones, DI, Huffman, T, Edwards, RW, Dennis, M, Li, SH, Jha, S, Goodman, D, Kumar, A, LaBranche, CC, Montefiori, DC, Fouda, GG, Hope, TJ, Tomaras, GD, Staats, HF, Ferrari, G, and Permar, SR. "Bridging Vaccine-Induced HIV-1 Neutralizing and Effector Antibody Responses in Rabbit and Rhesus Macaque Animal Models." Journal of Virology 93, no. 10 (May 2019).

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Pardi, N, LaBranche, CC, Ferrari, G, Cain, DW, Tombácz, I, Parks, RJ, Muramatsu, H, Mui, BL, Tam, YK, Karikó, K, Polacino, P, Barbosa, CJ, Madden, TD, Hope, MJ, Haynes, BF, Montefiori, DC, Hu, S-L, and Weissman, D. "Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques." Molecular Therapy. Nucleic Acids 15 (April 2019): 36-47.

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Dennis, M, Eudailey, J, Pollara, J, McMillan, AS, Cronin, KD, Saha, PT, Curtis, AD, Hudgens, MG, Fouda, GG, Ferrari, G, Alam, M, Van Rompay, KKA, De Paris, K, Permar, S, and Shen, X. "Coadministration of CH31 Broadly Neutralizing Antibody Does Not Affect Development of Vaccine-Induced Anti-HIV-1 Envelope Antibody Responses in Infant Rhesus Macaques." Journal of Virology 93, no. 5 (March 2019).

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Curtis, AD, Walter, KA, Nabi, R, Jensen, K, Dwivedi, A, Pollara, J, Ferrari, G, Van Rompay, KKA, Amara, RR, Kozlowski, PA, and De Paris, K. "Oral Coadministration of an Intramuscular DNA/Modified Vaccinia Ankara Vaccine for Simian Immunodeficiency Virus Is Associated with Better Control of Infection in Orally Exposed Infant Macaques." Aids Research and Human Retroviruses 35, no. 3 (March 2019): 310-325.

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Asbach, B, Kibler, KV, Köstler, J, Perdiguero, B, Yates, NL, Stanfield-Oakley, S, Tomaras, GD, Kao, S-F, Foulds, KE, Roederer, M, Seaman, MS, Montefiori, DC, Parks, R, Ferrari, G, Forthal, DN, Phogat, S, Tartaglia, J, Barnett, SW, Self, SG, Gottardo, R, Cristillo, AD, Weiss, DE, Galmin, L, Ding, S, Heeney, JL, Esteban, M, Jacobs, BL, Pantaleo, G, and Wagner, R. "Priming with a Potent HIV-1 DNA Vaccine Frames the Quality of Immune Responses prior to a Poxvirus and Protein Boost." February 2019.

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Kibler, KV, Asbach, B, Perdiguero, B, García-Arriaza, J, Yates, NL, Parks, R, Stanfield-Oakley, S, Ferrari, G, Montefiori, DC, Tomaras, GD, Roederer, M, Foulds, KE, Forthal, DN, Seaman, MS, Self, S, Gottardo, R, Phogat, S, Tartaglia, J, Barnett, S, Cristillo, AD, Weiss, D, Galmin, L, Ding, S, Heeney, JL, Esteban, M, Wagner, R, Pantaleo, G, and Jacobs, BL. "Replication-Competent NYVAC-KC Yields Improved Immunogenicity to HIV-1 Antigens in Rhesus Macaques Compared to Nonreplicating NYVAC." Journal of Virology 93, no. 3 (February 2019).

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Pantaleo, G, Janes, H, Karuna, S, Grant, S, Ouedraogo, L, Allen, M, Tomaras, GD, Frahm, N, Montefiori, DC, Ferrari, G, Ding, S, Lee, C, Robb, ML, Esteban, M, Wagner, R, Alexandre-Bart, P, Rettby, N, McElrath, MJ, Gilbert, PB, Kublin, J, Corey, L, and Trials Network, NIAIDHIVV. "Co-Administration of HIV Env Protein with DNA and/or NYVAC Vaccines in Humans Results in Earlier and Potent Generation of Anti-Env Antibody Responses." (January 25, 2019).

Scholars@Duke

Spearman, P, Tomaras, GD, Montefiori, DC, Huang, Y, Elizaga, ML, Ferrari, G, Alam, SM, Isaacs, A, Ahmed, H, Hural, J, McElrath, MJ, Ouedraogo, L, Pensiero, M, Butler, C, Kalams, SA, Overton, ET, Barnett, SW, HVTN 088 Protocol Team, , and NIH/NIAID HIV Vaccine Trials Network, . "Rapid Boosting of HIV-1 Neutralizing Antibody Responses in Humans Following a Prolonged Immunologic Rest." The Journal of Infectious Diseases (January 7, 2019).

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van Eeden, C, Wibmer, CK, Scheepers, C, Richardson, SI, Nonyane, M, Lambson, B, Mkhize, NN, Vijayakumar, B, Sheng, Z, Stanfield-Oakley, S, Bhiman, JN, Bekker, V, Hermanus, T, Mabvakure, B, Ismail, A, Moody, MA, Wiehe, K, Garrett, N, Karim, SA, Dirr, H, Fernandes, MA, Sayed, Y, Shapiro, L, Ferrari, G, Haynes, BF, Moore, PL, and Morris, L. "V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity." Cell Reports 25, no. 11 (December 2018): 3123-3135.e6.

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Himes, JE, Goswami, R, Mangan, RJ, Kumar, A, Jeffries, TL, Eudailey, JA, Heimsath, H, Nguyen, QN, Pollara, J, LaBranche, C, Chen, M, Vandergrift, NA, Peacock, JW, Schiro, F, Midkiff, C, Ferrari, G, Montefiori, DC, Hernandez, XA, Aye, PP, and Permar, SR. "Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys." Mucosal Immunology 11, no. 6 (November 2018): 1716-1726.

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