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Guido Ferrari, MD

Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

Over the past eleven years, I have built an independent basic research and immune monitoring laboratory with continuous NIH and Bill & Melinda Gates Foundation funding and continue to develop productive collaboration within and outside Duke University Medical Center, allowing me to expand my focus of research. Overall, I have been interested in understanding the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates. Lately, I have also started investigating the influence of CD4+ T cell responses that may support the production of broadly neutralizing Ab following HIV-1 infection. In summary, the research in my laboratory revolves around three topics of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in T cellular subsets upon infection with HIV-1.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Wills, S, Hwang, K-K, Liu, P, Dennison, SM, Zirui Tay, M, Shen, X, Pollara, J, Lucas, JT, Parks, R, Rerks-Ngarm, S, Pitisuttithum, P, Nitayapan, S, Kaewkungwal, J, Thomas, R, Kim, JH, Michael, NL, Robb, ML, McRaven, M, Montefiori, DC, Hope, TJ, Liao, H-X, Moody, MA, Ferrari, G, Haynes, BF, Alam, SM, Bonsignori, M, and Tomaras, GD. "HIV-1 specific IgA Monoclonal Antibodies from an HIV-1 Vaccinee Mediate Galcer Blocking and Phagocytosis." Journal of virology (January 10, 2018).

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Eudailey, JA, Dennis, ML, Parker, ME, Phillips, BL, Huffman, TN, Bay, CP, Hudgens, MG, Wiseman, RW, Pollara, JJ, Fouda, GG, Ferrari, G, Pickup, DJ, Kozlowski, PA, Van Rompay, KKA, De Paris, K, and Permar, SR. "Maternal HIV-1 Env Vaccination for Systemic and Breast Milk Immunity To Prevent Oral SHIV Acquisition in Infant Macaques." mSphere 3, no. 1 (January 10, 2018).

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Fong, Y, Shen, X, Ashley, VC, Deal, A, Seaton, KE, Yu, C, Grant, SP, Ferrari, G, deCamp, AC, Bailer, RT, Koup, RA, Montefiori, D, Haynes, BF, Sarzotti-Kelsoe, M, Graham, BS, Carpp, LN, Hammer, SM, Sobieszczyk, M, Karuna, S, Swann, E, DeJesus, E, Mulligan, M, Frank, I, Buchbinder, S, Novak, RM, McElrath, MJ, Kalams, S, Keefer, M, Frahm, NA, Janes, HE, Gilbert, PB, and Tomaras, GD. "Vaccine-induced antibody responses modify the association between T-cell immune responses and HIV-1 infection risk in HVTN 505." The Journal of infectious diseases (January 8, 2018).

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Jones, AT, Chamcha, V, Kesavardhana, S, Shen, X, Beaumont, D, Das, R, Wyatt, LS, LaBranche, CC, Stanfield-Oakley, S, Ferrari, G, Montefiori, DC, Moss, B, Tomaras, GD, Varadarajan, R, and Amara, RR. "A trimeric HIV-1 envelope gp120 immunogen induces potent and broad anti-V1V2 loop antibodies against HIV-1 in rabbits and rhesus macaques." Journal of Virology (December 13, 2017).

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Shen, X, Basu, R, Sawant, S, Beaumont, D, Kwa, SF, LaBranche, C, Seaton, KE, Yates, NL, Montefiori, DC, Ferrari, G, Wyatt, LS, Moss, B, Alam, SM, Haynes, BF, Tomaras, GD, and Robinson, HL. "HIV-1 gp120 and Modified Vaccinia Virus Ankara (MVA) gp140 Boost Immunogens Increase Immunogenicity of a DNA/MVA HIV-1 Vaccine." Journal of virology 91, no. 24 (December 2017).

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Francica, JR, Zak, DE, Linde, C, Siena, E, Johnson, C, Juraska, M, Yates, NL, Gunn, B, De Gregorio, E, Flynn, BJ, Valiante, NM, Malyala, P, Barnett, SW, Sarkar, P, Singh, M, Jain, S, Ackerman, M, Alam, M, Ferrari, G, Tomaras, GD, O'Hagan, DT, Aderem, A, Alter, G, and Seder, RA. "Innate transcriptional effects by adjuvants on the magnitude, quality, and durability of HIV envelope responses in NHPs." Blood advances 1, no. 25 (November 17, 2017): 2329-2342.

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Mayer, KH, Seaton, KE, Huang, Y, Grunenberg, N, Isaacs, A, Allen, M, Ledgerwood, JE, Frank, I, Sobieszczyk, ME, Baden, LR, Rodriguez, B, Van Tieu, H, Tomaras, GD, Deal, A, Goodman, D, Bailer, RT, Ferrari, G, Jensen, R, Hural, J, Graham, BS, Mascola, JR, Corey, L, Montefiori, DC, HVTN 104 Protocol Team, , and and the NIAID HIV Vaccine Trials Network, . "Safety, pharmacokinetics, and immunological activities of multiple intravenous or subcutaneous doses of an anti-HIV monoclonal antibody, VRC01, administered to HIV-uninfected adults: Results of a phase 1 randomized trial." PLoS medicine 14, no. 11 (November 14, 2017): e1002435-.

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Viegas, EO, Tembe, N, Nilsson, C, Meggi, B, Maueia, C, Augusto, O, Stout, R, Scarlatti, G, Ferrari, G, Earl, PL, Wahren, B, Andersson, S, Robb, ML, Osman, N, Biberfeld, G, Jani, I, and Sandström, E. "Intradermal HIV-1 DNA Immunization Using Needle-Free Zetajet Injection Followed by HIV-Modified Vaccinia Virus Ankara Vaccination Is Safe and Immunogenic in Mozambican Young Adults: A Phase I Randomized Controlled Trial." AIDS research and human retroviruses (November 2017).

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Liu, D, Wang, C, Hora, B, Zuo, T, Goonetilleke, N, Liu, MKP, Berrong, M, Ferrari, G, McMichael, AJ, Bhattacharya, T, Perelson, AS, and Gao, F. "A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies." Retrovirology 14, no. 1 (October 10, 2017): 46-.

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Shen, X, Bogers, WM, Yates, NL, Ferrari, G, Dey, AK, Williams, WT, Jaeger, FH, Wiehe, K, Sawant, S, Alam, SM, LaBranche, CC, Montefiori, DC, Martin, L, Srivastava, I, Heeney, J, Barnett, SW, and Tomaras, GD. "Cross-Linking of a CD4-Mimetic Miniprotein with HIV-1 Env gp140 Alters Kinetics and Specificities of Antibody Responses against HIV-1 Env in Macaques." Journal of virology 91, no. 19 (October 2017).

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