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Guido Ferrari, MD

Professor in Surgery
Research Professor in Molecular Genetics and Microbiology
Division: 
Surgical Sciences
Faculty Lab: 
Innate and Adaptive Cellular Cytotoxicity Laboratory
Office: 915 S. Lasalle Street, Sorf Building Room 208, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

In the News

Selected Grants

Publications

Saunders, Kevin O., Norbert Pardi, Robert Parks, Sampa Santra, Zekun Mu, Laura Sutherland, Richard Scearce, et al. “Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates.” Npj Vaccines 6, no. 1 (April 9, 2021): 50. https://doi.org/10.1038/s41541-021-00307-6.

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Tolbert, William D., Verna Van, Rebekah Sherburn, Marina Tuyishime, Fang Yan, Dung N. Nguyen, Sherry Stanfield-Oakley, et al. “Erratum for Tolbert et al., "Recognition Patterns of the C1/C2 Epitopes Involved in Fc-Mediated Response in HIV-1 Natural Infection and the RV114 Vaccine Trial".” Mbio 12, no. 2 (April 6, 2021). https://doi.org/10.1128/mBio.00474-21.

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Andersen-Nissen, Erica, Andrew Fiore-Gartland, Lamar Ballweber Fleming, Lindsay N. Carpp, Anneta F. Naidoo, Michael S. Harper, Valentin Voillet, et al. “Innate immune signatures to a partially-efficacious HIV vaccine predict correlates of HIV-1 infection risk.” Plos Pathog 17, no. 3 (March 2021): e1009363. https://doi.org/10.1371/journal.ppat.1009363.

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Silva de Castro, Isabela, Giacomo Gorini, Rosemarie Mason, Jason Gorman, Massimiliano Bissa, Mohammad A. Rahman, Anush Arakelyan, et al. “Anti-V2 antibodies virus vulnerability revealed by envelope V1 deletion in HIV vaccine candidates.” Iscience 24, no. 2 (February 19, 2021): 102047. https://doi.org/10.1016/j.isci.2021.102047.

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Chattopadhyay, Pratip K., Andrew Filby, Evan R. Jellison, Guido Ferrari, Cherie Green, Sindhu Cherian, Jonathan Irish, Virginia Litwin, and Virginia other members of the ISAC COVID-19 Work Group. “A Cytometrist's Guide to Coordinating and Performing Effective COVID-19 Research.” Cytometry A 99, no. 1 (January 2021): 11–18. https://doi.org/10.1002/cyto.a.24210.

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Pollara, Justin, Matthew Zirui Tay, R Whitney Edwards, Derrick Goodman, Andrew R. Crowley, Robert J. Edwards, David Easterhoff, et al. “Functional Homology for Antibody-Dependent Phagocytosis Across Humans and Rhesus Macaques.” Front Immunol 12 (2021): 678511. https://doi.org/10.3389/fimmu.2021.678511.

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Msafiri, Frank, Agricola Joachim, Kathrin Held, Yuka Nadai, Raquel Matavele Chissumba, Christof Geldmacher, Said Aboud, et al. “Frequent Anti-V1V2 Responses Induced by HIV-DNA Followed by HIV-MVA with or without CN54rgp140/GLA-AF in Healthy African Volunteers.” In Microorganisms, Vol. 8, 2020. https://doi.org/10.3390/microorganisms8111722.

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Gay, Cynthia L., Dayna T. Neo, Aaron S. Devanathan, Joann D. Kuruc, Kara S. McGee, John L. Schmitz, Joe Sebastian, et al. “Efficacy, pharmacokinetics and neurocognitive performance of dual, NRTI-sparing antiretroviral therapy in acute HIV-infection.” Aids 34, no. 13 (November 1, 2020): 1923–31. https://doi.org/10.1097/QAD.0000000000002652.

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Dashti, Amir, Chevaughn Waller, Maud Mavigner, Nils Schoof, Katharine J. Bar, George M. Shaw, Thomas H. Vanderford, et al. “SMAC Mimetic Plus Triple-Combination Bispecific HIVxCD3 Retargeting Molecules in SHIV.C.CH505-Infected, Antiretroviral Therapy-Suppressed Rhesus Macaques.” In J Virol, Vol. 94, 2020. https://doi.org/10.1128/JVI.00793-20.

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Tuyishime, Marina, Carolina Garrido, Shalini Jha, Matt Moeser, Dieter Mielke, Celia LaBranche, David Montefiori, et al. “Improved killing of HIV-infected cells using three neutralizing and non-neutralizing antibodies.” J Clin Invest 130, no. 10 (October 1, 2020): 5157–70. https://doi.org/10.1172/JCI135557.

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