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Guido Ferrari, MD

Associate Professor of Surgery
Associate Research Professor in Molecular Genetics and Microbiology
Office: 115 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

The activities of the Ferrari Laboratory are based on both independent basic research and immune monitoring studies. The research revolves around three main areas of interest: class I-mediated cytotoxic CD8+ T cell responses, antibody-dependent cellular cytotoxicity (ADCC), gene expression in NK and T cellular subsets upon infection with HIV-1. With continuous funding over the last 11 years from the NIH and Bill & Melinda Gates Foundation along with many other productive collaborations within and outside of Duke, the Ferrari Lab has expanded its focus of research to include the ontogeny of HIV-1 specific immune responses that work by eliminating HIV-1 infected cells and how these can be induced by AIDS vaccine candidates.

Education and Training

  • M.D., University of Genoa (Italy), 1985

Selected Grants

Publications

Wise, Megan C., Ziyang Xu, Edgar Tello-Ruiz, Charles Beck, Aspen Trautz, Ami Patel, Sarah Tc Elliott, et al. “In vivo delivery of synthetic DNA-encoded antibodies induces broad HIV-1-neutralizing activity..” J Clin Invest, November 7, 2019. https://doi.org/10.1172/JCI132779.

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Neidich, Scott D., Youyi Fong, Shuying S. Li, Daniel E. Geraghty, Brian D. Williamson, William Chad Young, Derrick Goodman, et al. “Antibody Fc effector functions and IgG3 associate with decreased HIV-1 risk..” J Clin Invest 129, no. 11 (November 1, 2019): 4838–49. https://doi.org/10.1172/JCI126391.

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Kibler, Karen V., Benedikt Asbach, Beatriz Perdiguero, Juan García-Arriaza, Nicole L. Yates, Robert Parks, Sherry Stanfield-Oakley, et al. “Correction for Kibler et al., "Replication-Competent NYVAC-KC Yields Improved Immunogenicity to HIV-1 Antigens in Rhesus Macaques Compared to Nonreplicating NYVAC"..” J Virol 93, no. 21 (November 1, 2019). https://doi.org/10.1128/JVI.00968-19.

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Rouphael, Nadine G., Cecilia Morgan, Shuying S. Li, Ryan Jensen, Brittany Sanchez, Shelly Karuna, Edith Swann, et al. “DNA priming and gp120 boosting induces HIV-specific antibodies in a randomized clinical trial..” J Clin Invest 129, no. 11 (November 1, 2019): 4769–85. https://doi.org/10.1172/JCI128699.

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Li, Shuying S., Peter B. Gilbert, Lindsay N. Carpp, Chul-Woo Pyo, Holly Janes, Youyi Fong, Xiaoying Shen, et al. “Fc Gamma Receptor Polymorphisms Modulated the Vaccine Effect on HIV-1 Risk in the HVTN 505 HIV Vaccine Trial..” J Virol 93, no. 21 (November 1, 2019). https://doi.org/10.1128/JVI.02041-18.

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Pantaleo, Giuseppe, Holly Janes, Shelly Karuna, Shannon Grant, G Laissa Ouedraogo, Mary Allen, Georgia D. Tomaras, et al. “Safety and immunogenicity of a multivalent HIV vaccine comprising envelope protein with either DNA or NYVAC vectors (HVTN 096): a phase 1b, double-blind, placebo-controlled trial..” Lancet Hiv 6, no. 11 (November 2019): e737–49. https://doi.org/10.1016/S2352-3018(19)30262-0.

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Gray, Glenda E., Ying Huang, Nicole Grunenberg, Fatima Laher, Surita Roux, Erica Andersen-Nissen, Stephen C. De Rosa, et al. “Immune correlates of the Thai RV144 HIV vaccine regimen in South Africa..” Sci Transl Med 11, no. 510 (September 18, 2019). https://doi.org/10.1126/scitranslmed.aax1880.

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Nyanhete, Tinashe E., Alyse L. Frisbee, Todd Bradley, William J. Faison, Elizabeth Robins, Tamika Payne, Stephanie A. Freel, et al. “HLA class II-Restricted CD8+ T cells in HIV-1 Virus Controllers..” Sci Rep 9, no. 1 (July 15, 2019). https://doi.org/10.1038/s41598-019-46462-8.

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Pollara, Justin, Dorothy I. Jones, Tori Huffman, R Whitney Edwards, Maria Dennis, Shuk Hang Li, Shalini Jha, et al. “Bridging Vaccine-Induced HIV-1 Neutralizing and Effector Antibody Responses in Rabbit and Rhesus Macaque Animal Models..” J Virol 93, no. 10 (May 15, 2019). https://doi.org/10.1128/JVI.02119-18.

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Spearman, Paul, Georgia D. Tomaras, David C. Montefiori, Ying Huang, Marnie L. Elizaga, Guido Ferrari, S Munir Alam, et al. “Rapid Boosting of HIV-1 Neutralizing Antibody Responses in Humans Following a Prolonged Immunologic Rest Period..” J Infect Dis 219, no. 11 (May 5, 2019): 1755–65. https://doi.org/10.1093/infdis/jiz008.

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