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Georgia Doris Tomaras, PhD

Professor in Surgery
Professor in Immunology
Professor in Molecular Genetics and Microbiology
Office: 300 N Duke St, Durham, NC 27701
Campus Mail: DUMC Box 104777 DUMC, Bay 47 Carmichael Bldg, 300 N. Duke St, Durham, NC 27701

Research in the Tomaras Laboratory in the Duke Human Vaccine Institute and Departments of Surgery, Immunology, and Molecular Genetics and Microbiology at Duke University Medical Center, focuses on the identification of immune correlates of protection for preventative vaccines and identification of the mechanisms responsible for potent inhibition of human pathogens.  

Education and Training

  • Postdoctoral Fellowship, Center For Aids Research, Department Of Surgery, Duke University, 1998 - 2001
  • Ph.D., State University of New York Upstate Medical University, 1998

Selected Grants

Publications

Asbach, Benedikt, Karen V. Kibler, Josef Köstler, Beatriz Perdiguero, Nicole L. Yates, Sherry Stanfield-Oakley, Georgia D. Tomaras, et al. “Priming with a Potent HIV-1 DNA Vaccine Frames the Quality of Immune Responses prior to a Poxvirus and Protein Boost.” In J Virol, Vol. 93, 2019. https://doi.org/10.1128/JVI.01529-18.

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Kibler, Karen V., Benedikt Asbach, Beatriz Perdiguero, Juan García-Arriaza, Nicole L. Yates, Robert Parks, Sherry Stanfield-Oakley, et al. “Replication-Competent NYVAC-KC Yields Improved Immunogenicity to HIV-1 Antigens in Rhesus Macaques Compared to Nonreplicating NYVAC.” J Virol 93, no. 3 (February 1, 2019). https://doi.org/10.1128/JVI.01513-18.

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Pantaleo, Giuseppe, Holly Janes, Shelly Karuna, Shannon Grant, Laissa Ouedraogo, Mary Allen, Georgia D. Tomaras, et al. “Co-Administration of HIV Env Protein with DNA and/or NYVAC Vaccines in Humans Results in Earlier and Potent Generation of Anti-Env Antibody Responses.” The Lancet Hiv, Volume 6, no. 11 (January 25, 2019).

Scholars@Duke

Mielke, Dieter, Gama Bandawe, Justin Pollara, Melissa-Rose Abrahams, Tinashe Nyanhete, Penny L. Moore, Ruwayhida Thebus, et al. “Antibody-Dependent Cellular Cytotoxicity (ADCC)-Mediating Antibodies Constrain Neutralizing Antibody Escape Pathway.” Front Immunol 10 (2019): 2875. https://doi.org/10.3389/fimmu.2019.02875.

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Cram, Jacob A., Andrew J. Fiore-Gartland, Sujatha Srinivasan, Shelly Karuna, Giuseppe Pantaleo, Georgia D. Tomaras, David N. Fredricks, and James G. Kublin. “Human gut microbiota is associated with HIV-reactive immunoglobulin at baseline and following HIV vaccination.” Plos One 14, no. 12 (2019): e0225622. https://doi.org/10.1371/journal.pone.0225622.

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Dahora, Lindsay C., Celina Jin, Rachel L. Spreng, Frederick Feely, Ryan Mathura, Kelly E. Seaton, Lu Zhang, et al. “IgA and IgG1 Specific to Vi Polysaccharide of Salmonella Typhi Correlate With Protection Status in a Typhoid Fever Controlled Human Infection Model.” Front Immunol 10 (2019): 2582. https://doi.org/10.3389/fimmu.2019.02582.

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Cohen, Yehuda Z., Allison L. Butler, Katrina Millard, Maggi Witmer-Pack, Rebeka Levin, Cecilia Unson-O’Brien, Roshni Patel, et al. “Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study.” Plos One 14, no. 8 (2019): e0219142. https://doi.org/10.1371/journal.pone.0219142.

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Fisher, Leigh, Melissa Zinter, Sherry Stanfield-Oakley, Lindsay N. Carpp, R Whitney Edwards, Thomas Denny, Zoe Moodie, et al. “Vaccine-Induced Antibodies Mediate Higher Antibody-Dependent Cellular Cytotoxicity After Interleukin-15 Pretreatment of Natural Killer Effector Cells.” Front Immunol 10 (2019): 2741. https://doi.org/10.3389/fimmu.2019.02741.

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