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Georgia Doris Tomaras, PhD

Professor in Surgery
Professor in Immunology
Professor in Molecular Genetics and Microbiology
Office: 300 N Duke St, Durham, NC 27701
Campus Mail: DUMC Box 104777 DUMC, Bay 47 Carmichael Bldg, 300 N. Duke St, Durham, NC 27701

Research in the Tomaras Laboratory in the Duke Human Vaccine Institute and Departments of Surgery, Immunology, and Molecular Genetics and Microbiology at Duke University Medical Center, focuses on the identification of immune correlates of protection for preventative vaccines and identification of the mechanisms responsible for potent inhibition of human pathogens.  

Education and Training

  • Postdoctoral Fellowship, Center For Aids Research, Department Of Surgery, Duke University, 1998 - 2001
  • Ph.D., State University of New York Upstate Medical University, 1998

Selected Grants

Publications

Seaton, Kelly E., Aaron Deal, Xue Han, Shuying S. Li, Ashley Clayton, Jack Heptinstall, Ann Duerr, et al. “Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans.” Npj Vaccines 6, no. 1 (April 15, 2021): 56. https://doi.org/10.1038/s41541-021-00305-8.

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Saunders, Kevin O., Norbert Pardi, Robert Parks, Sampa Santra, Zekun Mu, Laura Sutherland, Richard Scearce, et al. “Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates.” Npj Vaccines 6, no. 1 (April 9, 2021): 50. https://doi.org/10.1038/s41541-021-00307-6.

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Livingstone, Merricka C., Alexis A. Bitzer, Alish Giri, Kun Luo, Rajeshwer S. Sankhala, Misook Choe, Xiaoyan Zou, et al. “In vitro and in vivo inhibition of malaria parasite infection by monoclonal antibodies against Plasmodium falciparum circumsporozoite protein (CSP).” Sci Rep 11, no. 1 (March 5, 2021): 5318. https://doi.org/10.1038/s41598-021-84622-x.

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Andersen-Nissen, Erica, Andrew Fiore-Gartland, Lamar Ballweber Fleming, Lindsay N. Carpp, Anneta F. Naidoo, Michael S. Harper, Valentin Voillet, et al. “Innate immune signatures to a partially-efficacious HIV vaccine predict correlates of HIV-1 infection risk.” Plos Pathog 17, no. 3 (March 2021): e1009363. https://doi.org/10.1371/journal.ppat.1009363.

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Silva de Castro, Isabela, Giacomo Gorini, Rosemarie Mason, Jason Gorman, Massimiliano Bissa, Mohammad A. Rahman, Anush Arakelyan, et al. “Anti-V2 antibodies virus vulnerability revealed by envelope V1 deletion in HIV vaccine candidates.” Iscience 24, no. 2 (February 19, 2021): 102047. https://doi.org/10.1016/j.isci.2021.102047.

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Dennison, S. M., M. Reichartz, M. Abraha, R. L. Spreng, U. Wille-Reece, S. Dutta, E. Jongert, S. M. Alam, and G. D. Tomaras. “Magnitude, Specificity, and Avidity of Sporozoite-Specific Antibodies Associate with Protection Status and Distinguish among RTS,S/AS01 Dose Regimens.” Open Forum Infectious Diseases 8, no. 2 (February 1, 2021). https://doi.org/10.1093/ofid/ofaa644.

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Jin, Celina, Jennifer Hill, Bronwyn M. Gunn, Wen-Han Yu, Lindsay C. Dahora, Elizabeth Jones, Mari Johnson, et al. “Vi-specific serological correlates of protection for typhoid fever.” J Exp Med 218, no. 2 (February 1, 2021). https://doi.org/10.1084/jem.20201116.

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Hosseinipour, Mina C., Craig Innes, Sarita Naidoo, Philipp Mann, Julia Hutter, Gita Ramjee, Modulakgotla Sebe, et al. “Phase 1 Human Immunodeficiency Virus (HIV) Vaccine Trial to Evaluate the Safety and Immunogenicity of HIV Subtype C DNA and MF59-Adjuvanted Subtype C Envelope Protein.” Clin Infect Dis 72, no. 1 (January 23, 2021): 50–60. https://doi.org/10.1093/cid/ciz1239.

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Berendam, Stella J., Tiffany M. Styles, Papa K. Morgan-Asiedu, DeAnna Tenney, Amit Kumar, Veronica Obregon-Perko, Katharine J. Bar, et al. “Systematic Assessment of Antiviral Potency, Breadth, and Synergy of Triple Broadly Neutralizing Antibody Combinations against Simian-Human Immunodeficiency Viruses.” J Virol 95, no. 3 (January 13, 2021). https://doi.org/10.1128/JVI.01667-20.

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Tomic, Adriana, Ivan Tomic, Levi Waldron, Ludwig Geistlinger, Max Kuhn, Rachel L. Spreng, Lindsay C. Dahora, et al. “SIMON: Open-Source Knowledge Discovery Platform.” Patterns (N Y) 2, no. 1 (January 8, 2021): 100178. https://doi.org/10.1016/j.patter.2020.100178.

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