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Georgia Doris Tomaras, PhD

Professor in Surgery
Professor in Immunology
Professor in Molecular Genetics and Microbiology
Division: 
Surgical Sciences
Faculty Lab: 
Immune Responses and Virology Laboratory
Office: 300 N Duke St, Durham, NC 27701
Campus Mail: DUMC Box 104777 DUMC, Bay 47 Carmichael Bldg, 300 N. Duke St, Durham, NC 27701

Research in the Tomaras Laboratory in the Duke Human Vaccine Institute and Departments of Surgery, Immunology, and Molecular Genetics and Microbiology at Duke University Medical Center, focuses on the identification of immune correlates of protection for preventative vaccines and identification of the mechanisms responsible for potent inhibition of human pathogens.  

Education and Training

  • Postdoctoral Fellowship, Center For Aids Research, Department Of Surgery, Duke University, 1998 - 2001
  • Ph.D., State University of New York Upstate Medical University, 1998

In the News

Selected Grants

Publications

De Rosa, Stephen C., Srilatha Edupuganti, Yunda Huang, Xue Han, Marnie Elizaga, Edith Swann, Laura Polakowski, et al. “Robust antibody and cellular responses induced by DNA-only vaccination for HIV.” Jci Insight 5, no. 13 (July 9, 2020). https://doi.org/10.1172/jci.insight.137079.

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Kasturi, Sudhir Pai, Mohammed Ata Ur Rasheed, Colin Havenar-Daughton, Mathew Pham, Traci Legere, Zarpheen Jinnah Sher, Yevgeny Kovalenkov, et al. “3M-052, a synthetic TLR-7/8 agonist, induces durable HIV-1 envelope-specific plasma cells and humoral immunity in nonhuman primates.” Sci Immunol 5, no. 48 (June 19, 2020). https://doi.org/10.1126/sciimmunol.abb1025.

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Lévy, Yves, Christine Lacabaratz, Kim Ellefsen-Lavoie, Wolfgang Stöhr, Jean-Daniel Lelièvre, Pierre-Alexandre Bart, Odile Launay, et al. “Optimal priming of poxvirus vector (NYVAC)-based HIV vaccine regimens for T cell responses requires three DNA injections. Results of the randomized multicentre EV03/ANRS VAC20 Phase I/II Trial.” Plos Pathog 16, no. 6 (June 2020): e1008522. https://doi.org/10.1371/journal.ppat.1008522.

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Felber, Barbara K., Zhongyan Lu, Xintao Hu, Antonio Valentin, Margherita Rosati, Christopher A. L. Remmel, Joshua A. Weiner, et al. “Co-immunization of DNA and Protein in the Same Anatomical Sites Induces Superior Protective Immune Responses against SHIV Challenge.” Cell Rep 31, no. 6 (May 12, 2020): 107624. https://doi.org/10.1016/j.celrep.2020.107624.

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Moodie, Zoe, Stephen R. Walsh, Fatima Laher, Lucas Maganga, Michael E. Herce, Sarita Naidoo, Mina C. Hosseinipour, et al. “Antibody and cellular responses to HIV vaccine regimens with DNA plasmid as compared with ALVAC priming: An analysis of two randomized controlled trials.” Plos Med 17, no. 5 (May 2020): e1003117. https://doi.org/10.1371/journal.pmed.1003117.

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Bekker, Linda-Gail, One Dintwe, Andrew Fiore-Gartland, Keren Middelkoop, Julia Hutter, Anthony Williams, April K. Randhawa, et al. “A phase 1b randomized study of the safety and immunological responses to vaccination with H4:IC31, H56:IC31, and BCG revaccination in Mycobacterium tuberculosis-uninfected adolescents in Cape Town, South Africa.” Eclinicalmedicine 21 (April 2020): 100313. https://doi.org/10.1016/j.eclinm.2020.100313.

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Schifanella, Luca, Susan W. Barnett, Massimiliano Bissa, Veronica Galli, Melvin N. Doster, Monica Vaccari, Georgia D. Tomaras, et al. “Correction: ALVAC-HIV B/C candidate HIV vaccine efficacy dependent on neutralization profile of challenge virus and adjuvant dose and type.” Plos Pathog 16, no. 4 (April 2020): e1008531. https://doi.org/10.1371/journal.ppat.1008531.

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Gorini, Giacomo, Slim Fourati, Monica Vaccari, Mohammad Arif Rahman, Shari N. Gordon, Dallas R. Brown, Lynn Law, et al. “Engagement of monocytes, NK cells, and CD4+ Th1 cells by ALVAC-SIV vaccination results in a decreased risk of SIVmac251 vaginal acquisition.” Plos Pathog 16, no. 3 (March 2020): e1008377. https://doi.org/10.1371/journal.ppat.1008377.

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Silva de Castro, Isabela, Shari N. Gordon, Jun Liu, Massimiliano Bissa, Katherine McKinnon, Hung V. Trinh, Melvin N. Doster, et al. “Expression of CD40L by the ALVAC-Simian Immunodeficiency Virus Vector Abrogates T Cell Responses in Macaques.” J Virol 94, no. 6 (February 28, 2020). https://doi.org/10.1128/JVI.01933-19.

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Verma, Anil, Brian A. Schmidt, Sonny R. Elizaldi, Nancy K. Nguyen, Korey A. Walter, Zoltan Beck, Hung V. Trinh, et al. “Impact of Th1 CD4 Follicular Helper T Cell Skewing on Antibody Responses to an HIV-1 Vaccine in Rhesus Macaques.” J Virol 94, no. 6 (February 28, 2020). https://doi.org/10.1128/JVI.01737-19.

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