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Georgia Doris Tomaras, PhD

Professor in Surgery
Professor in Immunology
Professor in Molecular Genetics and Microbiology
Office: 300 N Duke St, Durham, NC 27701
Campus Mail: DUMC Box 104777 DUMC, Bay 47 Carmichael Bldg, 300 N. Duke St, Durham, NC 27701

Research in the Tomaras Laboratory in the Duke Human Vaccine Institute and Departments of Surgery, Immunology, and Molecular Genetics and Microbiology at Duke University Medical Center, focuses on the identification of immune correlates of protection for preventative vaccines and identification of the mechanisms responsible for potent inhibition of human pathogens.  

Education and Training

  • Postdoctoral Fellowship, Center For Aids Research, Department Of Surgery, Duke University, 1998 - 2001
  • Ph.D., State University of New York Upstate Medical University, 1998

Selected Grants

Publications

D’Souza, M Patricia, Amy C. Palin, Thomas Calder, Hana Golding, Steven H. Kleinstein, Erin L. Milliken, David O’Connor, Georgia Tomaras, Jon Warren, and Cesar Boggiano. “Mind the gap from research laboratory to clinic: Challenges and opportunities for next-generation assays in human diseases.” Vaccine 39, no. 37 (August 31, 2021): 5233–39. https://doi.org/10.1016/j.vaccine.2021.07.071.

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Seaton, Kelly E., Rachel L. Spreng, Milite Abraha, Matthew Reichartz, Michelle Rojas, Frederick Feely, Richard H. C. Huntwork, et al. “Subclass and avidity of circumsporozoite protein specific antibodies associate with protection status against malaria infection.” Npj Vaccines 6, no. 1 (August 30, 2021): 110. https://doi.org/10.1038/s41541-021-00372-x.

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Astronomo, Rena D., Maria P. Lemos, Sandeep R. Narpala, Julie Czartoski, Lamar Ballweber Fleming, Kelly E. Seaton, Madhu Prabhakaran, et al. “Rectal tissue and vaginal tissue from intravenous VRC01 recipients show protection against ex vivo HIV-1 challenge.” J Clin Invest 131, no. 16 (August 16, 2021). https://doi.org/10.1172/JCI146975.

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Pino, Maria, Talha Abid, Susan Pereira Ribeiro, Venkata Viswanadh Edara, Katharine Floyd, Justin C. Smith, Muhammad Bilal Latif, et al. “A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates.” Sci Immunol 6, no. 61 (July 15, 2021). https://doi.org/10.1126/sciimmunol.abh3634.

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Huang, Yunda, Kelly E. Seaton, Martin Casapia, Laura Polakowski, Stephen C. De Rosa, Kristen Cohen, Chenchen Yu, et al. “AIDSVAX protein boost improves breadth and magnitude of vaccine-induced HIV-1 envelope-specific responses after a 7-year rest period.” Vaccine 39, no. 33 (July 3, 2021): 4641–50. https://doi.org/10.1016/j.vaccine.2021.06.066.

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Chua, Joel V., Charles Davis, Jennifer S. Husson, Amy Nelson, Ilia Prado, Robin Flinko, Ka Wing J. Lam, et al. “Safety and immunogenicity of an HIV-1 gp120-CD4 chimeric subunit vaccine in a phase 1a randomized controlled trial.” Vaccine 39, no. 29 (June 29, 2021): 3879–91. https://doi.org/10.1016/j.vaccine.2021.05.090.

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Cai, Fangping, Wei-Hung Chen, Weimin Wu, Julia A. Jones, Misook Choe, Neelakshi Gohain, Xiaoying Shen, et al. “Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates.” Plos Pathog 17, no. 6 (June 2021): e1009624. https://doi.org/10.1371/journal.ppat.1009624.

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Seaton, Kelly E., Aaron Deal, Xue Han, Shuying S. Li, Ashley Clayton, Jack Heptinstall, Ann Duerr, et al. “Meta-analysis of HIV-1 vaccine elicited mucosal antibodies in humans.” Npj Vaccines 6, no. 1 (April 15, 2021): 56. https://doi.org/10.1038/s41541-021-00305-8.

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Saunders, Kevin O., Norbert Pardi, Robert Parks, Sampa Santra, Zekun Mu, Laura Sutherland, Richard Scearce, et al. “Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates.” Npj Vaccines 6, no. 1 (April 9, 2021): 50. https://doi.org/10.1038/s41541-021-00307-6.

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