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David Harold Harpole Jr., MD

Resident Research Director
Professor of Surgery
Associate Professor in Pathology
Professor in Pathology
Division: 
Cardiovascular and Thoracic Surgery
Program: 
General Surgery Residency Program
Office: Hock Plaza-2424 Erwin Rd, Suite 403 Room 4017, Durham, NC 27705
Campus Mail: DUMC Box 3627 Med Ctr, Durham, NC 27710

A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.

Education and Training

  • Instructor of Surgery, Surgery, Harvard University , 1996
  • M.D., University of Virginia, 1984

Selected Grants

Publications

Tong, B. C., and D. H. Harpole. “Molecular prognostication of lung cancer.” In Principles and Practice of Lung Cancer: The Official Reference Text of the International Association for the Study of Lung Cancer (IASLC): Fourth Edition, 147–62, 2012.

Scholars@Duke

Meyerson, S. L., and D. A. Harpole. “Anatomy of the thorax.” In General Thoracic Surgery: Seventh Edition, 1–2:76–102, 2011.

Scholars@Duke

Meyerson, S. L., and D. A. Harpole. “Mycotic and actinomycetic infections of the lung.” In General Thoracic Surgery: Seventh Edition, 1–2:3077–3128, 2011.

Scholars@Duke

Harpole, D. H., and M. Onaitis. “Present concepts in the molecular biology of lung cancer.” In General Thoracic Surgery: Seventh Edition, 2–2:3577–91, 2011.

Scholars@Duke

Ceppa, Duykhanh P., Ian J. Welsby, Tracy Y. Wang, Mark W. Onaitis, Betty C. Tong, David H. Harpole, Thomas A. D’Amico, and Mark F. Berry. “Perioperative management of patients on clopidogrel (Plavix) undergoing major lung resection.” The Annals of Thoracic Surgery 92, no. 6 (December 2011): 1971–76. https://doi.org/10.1016/j.athoracsur.2011.07.052.

Full Text

D’Alonzo, Richard C., Elliott Bennett-Guerrero, Mihai Podgoreanu, Thomas A. D’Amico, David H. Harpole, and Andrew D. Shaw. “A randomized, double blind, placebo controlled clinical trial of the preoperative use of ketamine for reducing inflammation and pain after thoracic surgery.” J Anesth 25, no. 5 (October 2011): 672–78. https://doi.org/10.1007/s00540-011-1206-4.

Full Text

Berry, Mark F., Mark W. Onaitis, Betty C. Tong, David H. Harpole, and Thomas A. D’Amico. “A model for morbidity after lung resection in octogenarians.” Eur J Cardiothorac Surg 39, no. 6 (June 2011): 989–94. https://doi.org/10.1016/j.ejcts.2010.09.038.

Full Text

Joshi, Marybeth M., Loretta Erhunmwunsee, Debbi H. Conlon, and David H. Harpole. “NEIGHBORHOOD-LEVEL SOCIOECONOMIC (SES) DETERMINANTS NEGATIVELY IMPACT TREATMENT DECISIONS AMONG NON-SMALL CELL LUNG CANCER PATIENTS IN THE SOUTHEASTERN UNITED STATES.” In Journal of Thoracic Oncology, 6:S327–28. LIPPINCOTT WILLIAMS & WILKINS, 2011.

Scholars@Duke

Higgins, Kristin A., Neal E. Ready, Thomas A. D’amico, Mark W. Onaitis, Jeffrey Crawford, Robert Clough, Mark F. Berry, et al. “PERSISTENT N2 DISEASE AFTER NEOADJUVANT CHEMOTHERAPY-NOW WHAT?” In Journal of Thoracic Oncology, 6:S1572–S1572. LIPPINCOTT WILLIAMS & WILKINS, 2011.

Scholars@Duke

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