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David Harold Harpole Jr., MD

Resident Research Director
Professor of Surgery
Associate Professor in Pathology
Professor in Pathology
Office: Hock Plaza-2424 Erwin Rd, Suite 403 Room 4017, Durham, NC 27705
Campus Mail: DUMC Box 3627 Med Ctr, Durham, NC 27710

A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.

Education and Training

  • Instructor of Surgery, Surgery, Harvard University , 1996
  • M.D., University of Virginia, 1984

Publications

Coles, John G., Kim Mr, Peter Mckeown, David H. Harpole, and Carl L. Backer. “Patient Genotypes Impact Survival After Surgery for Isolated Congenital Heart Disease DISCUSSION.” Annals of Thoracic Surgery. ELSEVIER SCIENCE INC, July 1, 2014.

Scholars@Duke

Harpole, W. S., and L. A. Biederman. “On the importance of accurate reporting: A response to comments on 'Biochar and its effects on plant productivity and nutrient cycling: A meta-analysis'.” Gcb Bioenergy 6, no. 3 (January 1, 2014): 172–75. https://doi.org/10.1111/gcbb.12093.

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Jaklitsch, Michael T., Lin Gu, Todd Demmy, David H. Harpole, Thomas A. D’Amico, Robert J. McKenna, Mark J. Krasna, et al. “Prospective phase II trial of preresection thoracoscopic mediastinal restaging after neoadjuvant therapy for IIIA (N2) non-small cell lung cancer: results of CALGB Protocol 39803.” J Thorac Cardiovasc Surg 146, no. 1 (July 2013): 9–16. https://doi.org/10.1016/j.jtcvs.2012.12.069.

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Grogan, Eric L., Stephen A. Deppen, Heidi Chen, Karla V. Ballman, Francys C. Verdial, Melinda C. Aldrich, Paul A. Decker, et al. “Abstract LB-296: FDG-PET avidity negatively impacts survival in pStage I NSCLC in the ACOSOG Z4031 trial.” In Clinical Research. American Association for Cancer Research, 2013. https://doi.org/10.1158/1538-7445.am2013-lb-296.

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Erhunmwunsee, Loretta, Mary-Beth M. Joshi, Debbi H. Conlon, and David H. Harpole. “Neighborhood-level socioeconomic determinants impact outcomes in nonsmall cell lung cancer patients in the Southeastern United States.” Cancer 118, no. 20 (October 15, 2012): 5117–23. https://doi.org/10.1002/cncr.26185.

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Cuneo, Kyle C., Richard F. Riedel, Leslie G. Dodd, David H. Harpole, and David G. Kirsch. “Pathologic complete response of a malignant peripheral nerve sheath tumor in the lung treated with neoadjuvant Ifosfamide and radiation therapy.” J Clin Oncol 30, no. 28 (October 1, 2012): e291–93. https://doi.org/10.1200/JCO.2012.42.8797.

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Ceppa, DuyKhanh P., Andrzej S. Kosinski, Mark F. Berry, Betty C. Tong, David H. Harpole, John D. Mitchell, Thomas A. D’Amico, and Mark W. Onaitis. “Thoracoscopic lobectomy has increasing benefit in patients with poor pulmonary function: a Society of Thoracic Surgeons Database analysis.” Ann Surg 256, no. 3 (September 2012): 487–93. https://doi.org/10.1097/SLA.0b013e318265819c.

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Patel, Pretesh R., Sua Yoo, Gloria Broadwater, Lawrence B. Marks, Edward F. Miles, Thomas A. D’Amico, David Harpole, and Chris R. Kelsey. “Effect of increasing experience on dosimetric and clinical outcomes in the management of malignant pleural mesothelioma with intensity-modulated radiation therapy.” Int J Radiat Oncol Biol Phys 83, no. 1 (May 1, 2012): 362–68. https://doi.org/10.1016/j.ijrobp.2011.11.057.

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Berry, Mark F., Mark W. Onaitis, Betty C. Tong, Stafford S. Balderson, David H. Harpole, and Thomas A. D’Amico. “Feasibility of hybrid thoracoscopic lobectomy and en-bloc chest wall resection.” Eur J Cardiothorac Surg 41, no. 4 (April 2012): 888–92. https://doi.org/10.1093/ejcts/ezr150.

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Shah, Asad A., Michael E. Barfield, Chris R. Kelsey, Mark W. Onaitis, Betty Tong, David Harpole, Thomas A. D’Amico, and Mark F. Berry. “Outcomes after surgical management of synchronous bilateral primary lung cancers.” Ann Thorac Surg 93, no. 4 (April 2012): 1055–60. https://doi.org/10.1016/j.athoracsur.2011.12.070.

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