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David Harold Harpole Jr., MD

Resident Research Director
Professor of Surgery
Associate Professor in Pathology
Professor in Pathology
Office: Hock Plaza-2424 Erwin Rd, Suite 403 Room 4017, Durham, NC 27705
Campus Mail: DUMC Box 3627 Med Ctr, Durham, NC 27710

A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.

Education and Training

  • Instructor of Surgery, Surgery, Harvard University , 1996
  • M.D., University of Virginia, 1984

Publications

Yang, Chi-Fu Jeffrey, Brian C. Gulack, Lin Gu, Paul J. Speicher, Xiaofei Wang, David H. Harpole, Mark W. Onaitis, Thomas A. D’Amico, Mark F. Berry, and Matthew G. Hartwig. “Adding radiation to induction chemotherapy does not improve survival of patients with operable clinical N2 non-small cell lung cancer.” J Thorac Cardiovasc Surg 150, no. 6 (December 2015): 1484–92. https://doi.org/10.1016/j.jtcvs.2015.06.062.

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Saunders, Laura R., Alexander J. Bankovich, Wade C. Anderson, Monette A. Aujay, Sheila Bheddah, KristenAnn Black, Radhika Desai, et al. “A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo.” Sci Transl Med 7, no. 302 (August 26, 2015): 302ra136. https://doi.org/10.1126/scitranslmed.aac9459.

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Berry, Mark F., Chi-Fu Jeffrey Yang, Matthew G. Hartwig, Betty C. Tong, David H. Harpole, Thomas A. D’Amico, and Mark W. Onaitis. “Impact of Pulmonary Function Measurements on Long-Term Survival After Lobectomy for Stage I Non-Small Cell Lung Cancer.” Ann Thorac Surg 100, no. 1 (July 2015): 271–76. https://doi.org/10.1016/j.athoracsur.2015.02.076.

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Yang, Chi-Fu Jeffrey, R Ryan Meyerhoff, Sarah J. Stephens, Terry Singhapricha, Christopher B. Toomey, Kevin L. Anderson, Chris Kelsey, David Harpole, Thomas A. D’Amico, and Mark F. Berry. “Long-Term Outcomes of Lobectomy for Non-Small Cell Lung Cancer After Definitive Radiation Treatment.” Ann Thorac Surg 99, no. 6 (June 2015): 1914–20. https://doi.org/10.1016/j.athoracsur.2015.01.064.

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Burt, Brian, Brian Kubasiak, and David H. Harpole. “Value of circulating insulin-like growth factor-associated proteins for the detection of stage I non-small cell lung cancer Discussion.” Journal of Thoracic and Cardiovascular Surgery. MOSBY-ELSEVIER, March 1, 2015.

Scholars@Duke

Rao, Vivek, Kindi Al, David H. Harpole, and Todd K. Rosengart. “Sustained release of milrinone delivered via microparticles in a rodent model of myocardial infarction Discussion.” Journal of Thoracic and Cardiovascular Surgery. MOSBY-ELSEVIER, November 1, 2014.

Scholars@Duke

Little, Alex G., Antoon E. Lerut, David H. Harpole, Wayne L. Hofstetter, John D. Mitchell, Nasser K. Altorki, and Mark J. Krasna. “The Society of Thoracic Surgeons practice guidelines on the role of multimodality treatment for cancer of the esophagus and gastroesophageal junction.” Ann Thorac Surg 98, no. 5 (November 2014): 1880–85. https://doi.org/10.1016/j.athoracsur.2014.07.069.

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Maddula, Krishna, Mary-Beth Joshi, Vijay Modur, and David H. Harpole. “Abstract 1904: RNA expression based screening of ALK gene fusion from formalin fixed non-small cell lung cancer samples.” In Clinical Research (Excluding Clinical Trials). American Association for Cancer Research, 2014. https://doi.org/10.1158/1538-7445.am2014-1904.

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Malik, Shakun M., Richard Pazdur, Jeffrey S. Abrams, Mark A. Socinski, William T. Sause, David H. Harpole, John J. Welch, Edward L. Korn, Claudio Dansky Ullmann, and Fred R. Hirsch. “Consensus report of a joint NCI thoracic malignancies steering committee: FDA workshop on strategies for integrating biomarkers into clinical development of new therapies for lung cancer leading to the inception of "master protocols" in lung cancer.” J Thorac Oncol 9, no. 10 (October 2014): 1443–48. https://doi.org/10.1097/JTO.0000000000000314.

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