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David Harold Harpole Jr., MD

Resident Research Director
Professor of Surgery
Associate Professor in Pathology
Professor in Pathology
Office: Hock Plaza-2424 Erwin Rd, Suite 403 Room 4017, Durham, NC 27705
Campus Mail: DUMC Box 3627 Med Ctr, Durham, NC 27710

A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.

Education and Training

  • Instructor of Surgery, Surgery, Harvard University , 1996
  • M.D., University of Virginia, 1984

Publications

Frater, P. N., E. T. Borer, P. A. Fay, V. Jin, B. Knaeble, E. Seabloom, L. Sullivan, D. A. Wedin, and W. S. Harpole. “Nutrients and environment influence arbuscular mycorrhizal colonization both independently and interactively in Schizachyrium scoparium.” Plant and Soil 425, no. 1–2 (April 1, 2018): 493–506. https://doi.org/10.1007/s11104-018-3597-6.

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Moris, Dimitrios, Ioannis Ntanasis-Stathopoulos, Diamantis I. Tsilimigras, Mohamad A. Adam, Chi-Fu Jeffrey Yang, David Harpole, and Stamatios Theocharis. “Insights into Novel Prognostic and Possible Predictive Biomarkers of Lung Neuroendocrine Tumors.” Cancer Genomics Proteomics 15, no. 2 (March 2018): 153–63. https://doi.org/10.21873/cgp.20073.

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Yang, Chi-Fu Jeffrey, Frances McSherry, Nicholas R. Mayne, Xiaofei Wang, Mark F. Berry, Betty Tong, David H. Harpole, et al. “Surgical Outcomes After Neoadjuvant Chemotherapy and Ipilimumab for Non-Small Cell Lung Cancer.” Ann Thorac Surg 105, no. 3 (March 2018): 924–29. https://doi.org/10.1016/j.athoracsur.2017.09.030.

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Hillebrand, H., B. Blasius, E. T. Borer, J. M. Chase, J. A. Downing, B. K. Eriksson, C. T. Filstrup, et al. “Biodiversity change is uncoupled from species richness trends: Consequences for conservation and monitoring.” Journal of Applied Ecology 55, no. 1 (January 1, 2018): 169–84. https://doi.org/10.1111/1365-2664.12959.

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Mortensen, B., B. Danielson, W. S. Harpole, J. Alberti, C. A. Arnillas, L. Biederman, E. T. Borer, et al. “Herbivores safeguard plant diversity by reducing variability in dominance.” Journal of Ecology 106, no. 1 (January 1, 2018): 101–12. https://doi.org/10.1111/1365-2745.12821.

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Hautier, Yann, Forest Isbell, Elizabeth T. Borer, Eric W. Seabloom, W Stanley Harpole, Eric M. Lind, Andrew S. MacDougall, et al. “Local loss and spatial homogenization of plant diversity reduce ecosystem multifunctionality.” Nat Ecol Evol 2, no. 1 (January 2018): 50–56. https://doi.org/10.1038/s41559-017-0395-0.

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Yi, John S., Neal Ready, Patrick Healy, Chelsae Dumbauld, Robyn Osborne, Mark Berry, Debra Shoemaker, et al. “Immune Activation in Early-Stage Non-Small Cell Lung Cancer Patients Receiving Neoadjuvant Chemotherapy Plus Ipilimumab.” Clin Cancer Res 23, no. 24 (December 15, 2017): 7474–82. https://doi.org/10.1158/1078-0432.CCR-17-2005.

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Boyer, Matthew J., Christina D. Williams, David H. Harpole, Mark W. Onaitis, Michael J. Kelley, and Joseph K. Salama. “Improved Survival of Stage I Non-Small Cell Lung Cancer: A VA Central Cancer Registry Analysis.” J Thorac Oncol 12, no. 12 (December 2017): 1814–23. https://doi.org/10.1016/j.jtho.2017.09.1952.

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Anderson, Kevin L., Michael S. Mulvihill, Paul J. Speicher, Babatunde A. Yerokun, Brian C. Gulack, Daniel P. Nussbaum, David H. Harpole, Thomas A. D’Amico, Mark F. Berry, and Matthew G. Hartwig. “Adjuvant Chemotherapy Does Not Confer Superior Survival in Patients With Atypical Carcinoid Tumors.” Ann Thorac Surg 104, no. 4 (October 2017): 1221–30. https://doi.org/10.1016/j.athoracsur.2017.05.011.

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Harpole, W. S., L. L. Sullivan, E. M. Lind, J. Firn, P. B. Adler, E. T. Borer, J. Chase, et al. “Out of the shadows: multiple nutrient limitations drive relationships among biomass, light and plant diversity.” Functional Ecology 31, no. 9 (September 1, 2017): 1839–46. https://doi.org/10.1111/1365-2435.12967.

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