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David Harold Harpole Jr., MD

Resident Research Director
Professor of Surgery
Associate Professor in Pathology
Professor in Pathology
Office: Hock Plaza-2424 Erwin Rd, Suite 403 Room 4017, Durham, NC 27705
Campus Mail: DUMC Box 3627 Med Ctr, Durham, NC 27710

A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.

Education and Training

  • Instructor of Surgery, Surgery, Harvard University , 1996
  • M.D., University of Virginia, 1984

Publications

Yang, Chi-Fu Jeffrey, Arvind Kumar, Jacob A. Klapper, Matthew G. Hartwig, Betty C. Tong, David H. Harpole, Mark F. Berry, and Thomas A. D’Amico. “A National Analysis of Long-term Survival Following Thoracoscopic Versus Open Lobectomy for Stage I Non-small-cell Lung Cancer.” Ann Surg 269, no. 1 (January 2019): 163–71. https://doi.org/10.1097/SLA.0000000000002342.

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Barac, Yaron D., David Harold Harpole, Kamrouz Ghadimi, and Carmelo A. Milano. “A One-Step Autotransplantation Can Facilitate the Excision of Cardiac Tumors Invading the Lung.” Semin Thorac Cardiovasc Surg 31, no. 3 (2019): 475–76. https://doi.org/10.1053/j.semtcvs.2019.01.012.

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Yu, Hui, Zhengming Chen, Karla V. Ballman, Mark A. Watson, Ramaswamy Govindan, Irena Lanc, David G. Beer, et al. “Correlation of PD-L1 Expression with Tumor Mutation Burden and Gene Signatures for Prognosis in Early-Stage Squamous Cell Lung Carcinoma.” J Thorac Oncol 14, no. 1 (January 2019): 25–36. https://doi.org/10.1016/j.jtho.2018.09.006.

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Yang, Chi-Fu Jeffrey, Derek Y. Chan, Shivani A. Shah, Babatunde A. Yerokun, Xiaofei F. Wang, Thomas A. D’Amico, Mark F. Berry, and David H. Harpole. “Long-term Survival After Surgery Compared With Concurrent Chemoradiation for Node-negative Small Cell Lung Cancer.” Ann Surg 268, no. 6 (December 2018): 1105–12. https://doi.org/10.1097/SLA.0000000000002287.

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Crowson, Matthew G., Betty C. Tong, Hui-Jie Lee, Yao Song, David H. Harpole, Harrison N. Jones, and Seth Cohen. “Prevalence and resource utilization for vocal fold paralysis/paresis after esophagectomy.” Laryngoscope 128, no. 12 (December 2018): 2815–22. https://doi.org/10.1002/lary.27252.

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Tsao, Anne S., O Wolf Lindwasser, Alex A. Adjei, Prasad S. Adusumilli, Matthew L. Beyers, Gideon M. Blumenthal, Raphael Bueno, et al. “Current and Future Management of Malignant Mesothelioma: A Consensus Report from the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer, and Mesothelioma Applied Research Foundation.” J Thorac Oncol 13, no. 11 (November 2018): 1655–67. https://doi.org/10.1016/j.jtho.2018.08.2036.

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Yang, Chi-Fu Jeffrey, Kelli Aibel, Ryan Meyerhoff, Frances Wang, David Harpole, Amy P. Abernethy, and Thomas W. LeBlanc. “Actigraphy assessment of sleep quality among patients with acute myeloid leukaemia during induction chemotherapy.” Bmj Support Palliat Care 8, no. 3 (September 2018): 274–77. https://doi.org/10.1136/bmjspcare-2018-001509.

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Hodapp, Dorothee, Elizabeth T. Borer, W Stanley Harpole, Eric M. Lind, Eric W. Seabloom, Peter B. Adler, Juan Alberti, et al. “Spatial heterogeneity in species composition constrains plant community responses to herbivory and fertilisation.” Ecol Lett 21, no. 9 (September 2018): 1364–71. https://doi.org/10.1111/ele.13102.

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Kröhnert, M., R. Anderson, J. Bumberger, P. Dietrich, W. S. Harpole, and H. G. Maas. “Watching grass grow - A pilot study on the suitability of photogrammetric techniques for quantifying change in Aboveground Biomass in Grassland experiments.” In International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences  Isprs Archives, 42:539–42, 2018. https://doi.org/10.5194/isprs-archives-XLII-2-539-2018.

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Anderson, T Michael, Daniel M. Griffith, James B. Grace, Eric M. Lind, Peter B. Adler, Lori A. Biederman, Dana M. Blumenthal, et al. “Herbivory and eutrophication mediate grassland plant nutrient responses across a global climatic gradient.” Ecology 99, no. 4 (April 2018): 822–31. https://doi.org/10.1002/ecy.2175.

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