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David Harold Harpole Jr., MD

Resident Research Director
Professor of Surgery
Associate Professor in Pathology
Professor in Pathology
Office: Hock Plaza-2424 Erwin Rd, Suite 403 Room 4017, Durham, NC 27705
Campus Mail: DUMC Box 3627 Med Ctr, Durham, NC 27710

A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.

Education and Training

  • Instructor of Surgery, Surgery, Harvard University , 1996
  • M.D., University of Virginia, 1984

Publications

Harpole, D. H., and R. H. Jones. “Serial assessment of ventricular performance after valve replacement for aortic stenosis.” J Thorac Cardiovasc Surg 99, no. 4 (April 1990): 645–50.

Scholars@Duke

Clements, F. M., D. H. Harpole, T. Quill, R. H. Jones, and R. L. McCann. “Estimation of left ventricular volume and ejection fraction by two-dimensional transoesophageal echocardiography: comparison of short axis imaging and simultaneous radionuclide angiography.” Br J Anaesth 64, no. 3 (March 1990): 331–36. https://doi.org/10.1093/bja/64.3.331.

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Harpole, D. H., C. Davidson, T. Skelton, R. H. Jones, and T. M. Bashore. “Serial evaluation of ventricular function after percutaneous aortic balloon valvuloplasty.” Am Heart J 119, no. 1 (January 1990): 130–35. https://doi.org/10.1016/s0002-8703(05)80092-4.

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Harpole, D. H., J. S. Rankin, W. G. Wolfe, L. R. Smith, W. G. Young, F. M. Clements, and R. H. Jones. “Assessment of left ventricular functional preservation during isolated cardiac valve operations.” Circulation 80, no. 5 Pt 2 (November 1989): III1–9.

Scholars@Duke

Harpole, D. H., F. M. Clements, T. Quill, W. G. Wolfe, R. H. Jones, and R. L. McCann. “Right and left ventricular performance during and after abdominal aortic aneurysm repair.” Ann Surg 209, no. 3 (March 1989): 356–62. https://doi.org/10.1097/00000658-198903000-00017.

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Davidson, C. J., D. A. Harpole, K. Kisslo, T. N. Skelton, J. Kisslo, R. H. Jones, and T. M. Bashore. “Analysis of the early rise in aortic transvalvular gradient after aortic valvuloplasty.” Am Heart J 117, no. 2 (February 1989): 411–17. https://doi.org/10.1016/0002-8703(89)90788-6.

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Harpole, D. H., C. Bigelow, W. G. Young, W. G. Wolfe, and D. C. Sabiston. “Alveolar cell carcinoma of the lung: a retrospective analysis of 205 patients.” Ann Thorac Surg 46, no. 5 (November 1988): 502–7. https://doi.org/10.1016/s0003-4975(10)64685-1.

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Wanebo, H. J., P. H. Cooper, D. V. Young, D. H. Harpole, and D. L. Kaiser. “Prognostic factors in head and neck melanoma. Effect of lesion location.” Cancer 62, no. 4 (August 15, 1988): 831–37. https://doi.org/10.1002/1097-0142(19880815)62:4<831::aid-cncr2820620432>3.0.co;2-x.

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HARPOLE, D. H. “RESECTION OF PULMONARY BULLOUS CYSTS WITH YAG LASER.” In Lasers in Surgery and Medicine, 8:195–195. WILEY-LISS, 1988.

Scholars@Duke

Wanebo, H. J., D. Harpole, and C. D. Teates. “Radionuclide lymphoscintigraphy with technetium 99m antimony sulfide colloid to identify lymphatic drainage of cutaneous melanoma at ambiguous sites in the head and neck and trunk.” Cancer 55, no. 6 (March 15, 1985): 1403–13. https://doi.org/10.1002/1097-0142(19850315)55:6<1403::aid-cncr2820550640>3.0.co;2-k.

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