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David Harold Harpole Jr., MD

Resident Research Director
Professor of Surgery
Associate Professor in Pathology
Professor in Pathology
Office: Hock Plaza-2424 Erwin Rd, Suite 403 Room 4017, Durham, NC 27705
Campus Mail: DUMC Box 3627 Med Ctr, Durham, NC 27710

A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.

Education and Training

  • Instructor of Surgery, Surgery, Harvard University , 1996
  • M.D., University of Virginia, 1984

Publications

Raman, Vignesh, Oliver K. Jawitz, Soraya L. Voigt, Norma E. Farrow, Chi-Fu J. Yang, Thomas A. D’Amico, and David H. Harpole. “Surgery Is Associated With Survival Benefit in T4a Esophageal Adenocarcinoma: A National Analysis.” Ann Thorac Surg 108, no. 6 (December 2019): 1633–39. https://doi.org/10.1016/j.athoracsur.2019.05.091.

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Berger, Miles, David M. Murdoch, Janet S. Staats, Cliburn Chan, Jake P. Thomas, Grant E. Garrigues, Jeffrey N. Browndyke, et al. “Flow Cytometry Characterization of Cerebrospinal Fluid Monocytes in Patients With Postoperative Cognitive Dysfunction: A Pilot Study.” Anesth Analg 129, no. 5 (November 2019): e150–54. https://doi.org/10.1213/ANE.0000000000004179.

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Tsao, Ming-Sound, Michele Carbone, Francoise Galateau-Salle, Andre L. Moreira, Andrew G. Nicholson, Anja C. Roden, Alex A. Adjei, et al. “Pathologic Considerations and Standardization in Mesothelioma Clinical Trials.” J Thorac Oncol 14, no. 10 (October 2019): 1704–17. https://doi.org/10.1016/j.jtho.2019.06.020.

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Gill, Ritu R., Anne S. Tsao, Hedy L. Kindler, William G. Richards, Samuel G. Armato, Roslyn J. Francis, Daniel R. Gomez, et al. “Radiologic Considerations and Standardization of Malignant Pleural Mesothelioma Imaging Within Clinical Trials: Consensus Statement from the NCI Thoracic Malignancy Steering Committee - International Association for the Study of Lung Cancer - Mesothelioma Applied Research Foundation Clinical Trials Planning Meeting.” J Thorac Oncol 14, no. 10 (October 2019): 1718–31. https://doi.org/10.1016/j.jtho.2019.08.012.

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Friedberg, Joseph S., Melissa J. Culligan, Anne S. Tsao, Valerie Rusch, Boris Sepesi, Harvey I. Pass, Raphael Bueno, et al. “A Proposed System Toward Standardizing Surgical-Based Treatments for Malignant Pleural Mesothelioma, From the Joint National Cancer Institute-International Association for the Study of Lung Cancer-Mesothelioma Applied Research Foundation Taskforce.” J Thorac Oncol 14, no. 8 (August 2019): 1343–53. https://doi.org/10.1016/j.jtho.2019.04.029.

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Raman, Vignesh, Oliver K. Jawitz, Chi-Fu J. Yang, Betty C. Tong, Thomas A. D’Amico, Mark F. Berry, and David H. Harpole. “Adjuvant Therapy for Patients With Early Large Cell Lung Neuroendocrine Cancer: A National Analysis.” Ann Thorac Surg 108, no. 2 (August 2019): 377–83. https://doi.org/10.1016/j.athoracsur.2019.03.053.

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Yu, Hui, Daniel T. Merrick, Ming-Sound Tsao, William G. Richards, Lucian R. Chirieac, Mark A. Watson, Christopher J. Rivard, et al. “Abstract 4550: Correlations between tumor mutation burden, inflammatory profile and histological characteristics of tumor microenvironment in early-stage squamous cell lung carcinoma.” In Tumor Biology. American Association for Cancer Research, 2019. https://doi.org/10.1158/1538-7445.sabcs18-4550.

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Gomez, Daniel R., Andreas Rimner, Charles B. Simone, BC John Cho, Marc de Perrot, Alex A. Adjei, Raphael Bueno, et al. “The Use of Radiation Therapy for the Treatment of Malignant Pleural Mesothelioma: Expert Opinion from the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer, and Mesothelioma Applied Research Foundation.” J Thorac Oncol 14, no. 7 (July 2019): 1172–83. https://doi.org/10.1016/j.jtho.2019.03.030.

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Klinger, Rebecca Y., Mary Cooter, Tiffany Bisanar, Niccolò Terrando, Miles Berger, Mihai V. Podgoreanu, Mark Stafford-Smith, Mark F. Newman, Joseph P. Mathew, and Joseph P. Neurologic Outcomes Research Group of the Duke Heart Center. “Intravenous Lidocaine Does Not Improve Neurologic Outcomes after Cardiac Surgery: A Randomized Controlled Trial.” Anesthesiology 130, no. 6 (June 2019): 958–70. https://doi.org/10.1097/ALN.0000000000002668.

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Berger, Miles, Deborah Oyeyemi, Mobolaji O. Olurinde, Heather E. Whitson, Kent J. Weinhold, Marty G. Woldorff, Lewis A. Lipsitz, et al. “The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction.” J Am Geriatr Soc 67, no. 4 (April 2019): 794–98. https://doi.org/10.1111/jgs.15770.

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