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David Harold Harpole Jr., MD

Resident Research Director
Professor of Surgery
Associate Professor in Pathology
Professor in Pathology
Office: Hock Plaza-2424 Erwin Rd, Suite 403 Room 4017, Durham, NC 27705
Campus Mail: DUMC Box 3627 Med Ctr, Durham, NC 27710

A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.

Education and Training

  • Instructor of Surgery, Surgery, Harvard University , 1996
  • M.D., University of Virginia, 1984

Publications

Raman, Vignesh, Oliver K. Jawitz, Chi-Fu Jeffrey Yang, Soraya L. Voigt, Thomas A. D’Amico, David H. Harpole, and Betty C. Tong. “The effect of extent of resection on outcomes in patients with limited stage small cell lung cancer.” In J Thorac Cardiovasc Surg, 161:1484-1492.e5, 2021. https://doi.org/10.1016/j.jtcvs.2020.02.135.

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Farrow, Norma E., Vignesh Raman, Oliver K. Jawitz, Soraya L. Voigt, Betty C. Tong, David H. Harpole, and Thomas A. D’Amico. “Impact of Age on Surgical Outcomes for Locally Advanced Esophageal Cancer.” Ann Thorac Surg 111, no. 3 (March 2021): 996–1003. https://doi.org/10.1016/j.athoracsur.2020.06.055.

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Rhodin, Kristen E., Vignesh Raman, Oliver K. Jawitz, Soraya L. Voigt, Norma E. Farrow, David H. Harpole, Betty C. Tong, and Thomas A. D’Amico. “Patterns of Use of Induction Therapy for T2N0 Esophageal Cancer.” Ann Thorac Surg 111, no. 2 (February 2021): 440–47. https://doi.org/10.1016/j.athoracsur.2020.05.089.

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Raman, Vignesh, Oliver K. Jawitz, Soraya L. Voigt, Kristen E. Rhodin, Thomas A. D’Amico, David H. Harpole, Chi-Fu Jeffrey Yang, and Betty C. Tong. “The Effect of Tumor Size and Histologic Findings on Outcomes After Segmentectomy vs Lobectomy for Clinically Node-Negative Non-Small Cell Lung Cancer.” Chest 159, no. 1 (January 2021): 390–400. https://doi.org/10.1016/j.chest.2020.06.066.

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Rucker, A Justin, Vignesh Raman, Oliver K. Jawitz, Soraya L. Voigt, Betty C. Tong, Thomas A. D’Amico, and David H. Harpole. “Effect of Lymph Node Assessment on Outcomes in Surgery for Limited Stage Small Cell Lung Cancer.” Ann Thorac Surg 110, no. 6 (December 2020): 1854–60. https://doi.org/10.1016/j.athoracsur.2020.04.117.

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Raman, Vignesh, Oliver K. Jawitz, Soraya L. Voigt, Kristen E. Rhodin, Anthony W. Kim, Betty C. Tong, Thomas A. D’Amico, and David H. Harpole. “Patterns of Care in Neoadjuvant Chemoradiotherapy for Node-Positive Esophageal Adenocarcinoma.” Ann Thorac Surg 110, no. 6 (December 2020): 1832–39. https://doi.org/10.1016/j.athoracsur.2020.05.069.

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Bueno, Raphael, William G. Richards, David H. Harpole, Karla V. Ballman, Ming-Sound Tsao, Zhengming Chen, Xiaofei Wang, et al. “Multi-Institutional Prospective Validation of Prognostic mRNA Signatures in Early Stage Squamous Lung Cancer (Alliance).” J Thorac Oncol 15, no. 11 (November 2020): 1748–57. https://doi.org/10.1016/j.jtho.2020.07.005.

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Voigt, Soraya L., Vignesh Raman, Oliver K. Jawitz, Muath Bishawi, Chi-Fu Jeffrey Yang, Betty C. Tong, Thomas A. D’Amico, and David H. Harpole. “The Role of Neoadjuvant Chemotherapy in Patients With Resectable Malignant Pleural Mesothelioma-An Institutional and National Analysis.” J Natl Cancer Inst 112, no. 11 (November 1, 2020): 1118–27. https://doi.org/10.1093/jnci/djaa002.

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Ganesh, Arun, Yawar J. Qadri, Richard L. Boortz-Marx, Sana M. Al-Khatib, David H. Harpole, Jason N. Katz, Jason I. Koontz, et al. “Stellate Ganglion Blockade: an Intervention for the Management of Ventricular Arrhythmias.” Curr Hypertens Rep 22, no. 12 (October 23, 2020): 100. https://doi.org/10.1007/s11906-020-01111-8.

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Rhodin, Kristen E., Vignesh Raman, Oliver K. Jawitz, Betty C. Tong, David H. Harpole, and Thomas A. D’Amico. “The Effect of Timing of Adjuvant Therapy on Survival After Esophagectomy.” Ann Thorac Surg 110, no. 3 (September 2020): 1023–29. https://doi.org/10.1016/j.athoracsur.2020.03.040.

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