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David Harold Harpole Jr., MD

Resident Research Director
Professor of Surgery
Associate Professor in Pathology
Professor in Pathology
Office: Hock Plaza-2424 Erwin Rd, Suite 403 Room 4017, Durham, NC 27705
Campus Mail: DUMC Box 3627 Med Ctr, Durham, NC 27710

A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.

Education and Training

  • Instructor of Surgery, Surgery, Harvard University , 1996
  • M.D., University of Virginia, 1984

Publications

Yang, C-FJ, Chan, DY, Shah, SA, Yerokun, BA, Wang, XF, D'Amico, TA, Berry, MF, and Harpole, DH. "Long-term Survival After Surgery Compared With Concurrent Chemoradiation for Node-negative Small Cell Lung Cancer." Annals of Surgery 268, no. 6 (December 2018): 1105-1112.

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Tsao, AS, Lindwasser, OW, Adjei, AA, Adusumilli, PS, Beyers, ML, Blumenthal, GM, Bueno, R, Burt, BM, Carbone, M, Dahlberg, SE, de Perrot, M, Fennell, DA, Friedberg, J, Gill, RR, Gomez, DR, Harpole, DH, Hassan, R, Hesdorffer, M, Hirsch, FR, Hmeljak, J, Kindler, HL, Korn, EL, Liu, G, Mansfield, AS, Nowak, AK, Pass, HI, Peikert, T, Rimner, A, Robinson, BWS, Rosenzweig, KE, Rusch, VW, Salgia, R, Sepesi, B, Simone, CB, Sridhara, R, Szlosarek, P, Taioli, E, Tsao, M-S, Yang, H, Zauderer, MG, and Malik, SM. "Current and Future Management of Malignant Mesothelioma: A Consensus Report from the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer, and Mesothelioma Applied Research Foundation." Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer 13, no. 11 (November 2018): 1655-1667.

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Yu, H, Chen, Z, Ballman, KV, Watson, MA, Govindan, R, Lanc, I, Beer, DG, Bueno, R, Chirieac, LR, Chui, MH, Chen, G, Franklin, WA, Gandara, DR, Genova, C, Brovsky, KA, Joshi, M-BM, Merrick, DT, Richards, WG, Rivard, CJ, Harpole, DH, Tsao, M-S, van Bokhoven, A, Shepherd, FA, and Hirsch, FR. "Correlation of PD-L1 Expression with Tumor Mutation Burden and Gene Signatures for Prognosis in Early-Stage Squamous Cell Lung Carcinoma." Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer (September 22, 2018).

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Crowson, MG, Tong, BC, Lee, H-J, Song, Y, Harpole, DH, Jones, HN, and Cohen, S. "Prevalence and resource utilization for vocal fold paralysis/paresis after esophagectomy." The Laryngoscope (September 19, 2018).

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Yang, C-FJ, Aibel, K, Meyerhoff, R, Wang, F, Harpole, D, Abernethy, AP, and LeBlanc, TW. "Actigraphy assessment of sleep quality among patients with acute myeloid leukaemia during induction chemotherapy." Bmj Supportive & Palliative Care 8, no. 3 (September 2018): 274-277.

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Hodapp, D, Borer, ET, Harpole, WS, Lind, EM, Seabloom, EW, Adler, PB, Alberti, J, Arnillas, CA, Bakker, JD, Biederman, L, Cadotte, M, Cleland, EE, Collins, S, Fay, PA, Firn, J, Hagenah, N, Hautier, Y, Iribarne, O, Knops, JMH, McCulley, RL, MacDougall, A, Moore, JL, Morgan, JW, Mortensen, B, La Pierre, KJ, Risch, AC, Schütz, M, Peri, P, Stevens, CJ, Wright, J, and Hillebrand, H. "Spatial heterogeneity in species composition constrains plant community responses to herbivory and fertilisation." Ecology Letters 21, no. 9 (September 2018): 1364-1371. (Letter)

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Anderson, TM, Griffith, DM, Grace, JB, Lind, EM, Adler, PB, Biederman, LA, Blumenthal, DM, Daleo, P, Firn, J, Hagenah, N, Harpole, WS, MacDougall, AS, McCulley, RL, Prober, SM, Risch, AC, Sankaran, M, Schütz, M, Seabloom, EW, Stevens, CJ, Sullivan, LL, Wragg, PD, and Borer, ET. "Herbivory and eutrophication mediate grassland plant nutrient responses across a global climatic gradient." Ecology 99, no. 4 (April 2018): 822-831.

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Frater, PN, Borer, ET, Fay, PA, Jin, V, Knaeble, B, Seabloom, E, Sullivan, L, Wedin, DA, and Harpole, WS. "Nutrients and environment influence arbuscular mycorrhizal colonization both independently and interactively in Schizachyrium scoparium." Plant and Soil 425, no. 1-2 (April 2018): 493-506.

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Moris, D, Ntanasis-Stathopoulos, I, Tsilimigras, DI, Adam, MA, Yang, C-FJ, Harpole, D, and Theocharis, S. "Insights into Novel Prognostic and Possible Predictive Biomarkers of Lung Neuroendocrine Tumors." Cancer Genomics & Proteomics 15, no. 2 (March 2018): 153-163. (Review)

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Yang, C-FJ, McSherry, F, Mayne, NR, Wang, X, Berry, MF, Tong, B, Harpole, DH, D'Amico, TA, Christensen, JD, Ready, NE, and Klapper, JA. "Surgical Outcomes After Neoadjuvant Chemotherapy and Ipilimumab for Non-Small Cell Lung Cancer." The Annals of Thoracic Surgery 105, no. 3 (March 2018): 924-929.

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