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David Harold Harpole Jr., MD

Resident Research Director
Professor of Surgery
Associate Professor in Pathology
Office: Hock Plaza-2424 Erwin Rd, Suite 403 Room 4017, Durham, NC 27705
Campus Mail: DUMC Box 3627 Med Ctr, Durham, NC 27710

A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.

Education and Training

  • Instructor of Surgery, Surgery, Harvard University , 1996
  • M.D., University of Virginia, 1984

Publications

Tsao, AS, Lindwasser, OW, Adjei, AA, Adusumilli, PS, Beyers, M, Blumenthal, GM, Bueno, R, Burt, BM, Carbone, M, Dahlberg, SE, de Perrot, M, Fennell, DA, Friedberg, J, Gill, RR, Gomez, DR, Harpole, DH, Hassan, R, Hesdorffer, M, Hirsch, FR, Hmeljak, J, Kindler, HL, Korn, EL, Liu, G, Mansfield, AS, Nowak, AK, Pass, HI, Peikert, T, Rimner, A, Robinson, BWS, Rosenzweig, KE, Rusch, VW, Salgia, R, Sepesi, B, Simone, CB, Sridhara, R, Szlosarek, P, Taioli, E, Tsao, M-S, Yang, H, Zauderer, MG, and Malik, SM. "Current and Future Management of Malignant Mesothelioma : A Consensus Report from the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer and Mesothelioma Applied Research Foundation." Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer (September 25, 2018).

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Crowson, MG, Tong, BC, Lee, H-J, Song, Y, Harpole, DH, Jones, HN, and Cohen, S. "Prevalence and resource utilization for vocal fold paralysis/paresis after esophagectomy." The Laryngoscope (September 19, 2018).

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Yang, C-FJ, Aibel, K, Meyerhoff, R, Wang, F, Harpole, D, Abernethy, AP, and LeBlanc, TW. "Actigraphy assessment of sleep quality among patients with acute myeloid leukaemia during induction chemotherapy." Bmj Supportive & Palliative Care 8, no. 3 (September 2018): 274-277.

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Hodapp, D, Borer, ET, Harpole, WS, Lind, EM, Seabloom, EW, Adler, PB, Alberti, J, Arnillas, CA, Bakker, JD, Biederman, L, Cadotte, M, Cleland, EE, Collins, S, Fay, PA, Firn, J, Hagenah, N, Hautier, Y, Iribarne, O, Knops, JMH, McCulley, RL, MacDougall, A, Moore, JL, Morgan, JW, Mortensen, B, La Pierre, KJ, Risch, AC, Schütz, M, Peri, P, Stevens, CJ, Wright, J, and Hillebrand, H. "Spatial heterogeneity in species composition constrains plant community responses to herbivory and fertilisation." Ecology Letters 21, no. 9 (September 2018): 1364-1371. (Letter)

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Anderson, TM, Griffith, DM, Grace, JB, Lind, EM, Adler, PB, Biederman, LA, Blumenthal, DM, Daleo, P, Firn, J, Hagenah, N, Harpole, WS, MacDougall, AS, McCulley, RL, Prober, SM, Risch, AC, Sankaran, M, Schütz, M, Seabloom, EW, Stevens, CJ, Sullivan, LL, Wragg, PD, and Borer, ET. "Herbivory and eutrophication mediate grassland plant nutrient responses across a global climatic gradient." Ecology 99, no. 4 (April 2018): 822-831.

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Frater, PN, Borer, ET, Fay, PA, Jin, V, Knaeble, B, Seabloom, E, Sullivan, L, Wedin, DA, and Harpole, WS. "Nutrients and environment influence arbuscular mycorrhizal colonization both independently and interactively in Schizachyrium scoparium." Plant and Soil 425, no. 1-2 (April 2018): 493-506.

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Moris, D, Ntanasis-Stathopoulos, I, Tsilimigras, DI, Adam, MA, Yang, C-FJ, Harpole, D, and Theocharis, S. "Insights into Novel Prognostic and Possible Predictive Biomarkers of Lung Neuroendocrine Tumors." Cancer Genomics & Proteomics 15, no. 2 (March 2018): 153-163. (Review)

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Yang, C-FJ, McSherry, F, Mayne, NR, Wang, X, Berry, MF, Tong, B, Harpole, DH, D'Amico, TA, Christensen, JD, Ready, NE, and Klapper, JA. "Surgical Outcomes After Neoadjuvant Chemotherapy and Ipilimumab for Non-Small Cell Lung Cancer." The Annals of Thoracic Surgery 105, no. 3 (March 2018): 924-929.

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Hillebrand, H, Blasius, B, Borer, ET, Chase, JM, Downing, JA, Eriksson, BK, Filstrup, CT, Harpole, WS, Hodapp, D, Larsen, S, Lewandowska, AM, Seabloom, EW, Van de Waal, DB, and Ryabov, AB. "Biodiversity change is uncoupled from species richness trends: Consequences for conservation and monitoring." Edited by Cadotte, M. Journal of Applied Ecology 55, no. 1 (January 2018): 169-184.

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Mortensen, B, Danielson, B, Harpole, WS, Alberti, J, Arnillas, CA, Biederman, L, Borer, ET, Cadotte, MW, Dwyer, JM, Hagenah, N, Hautier, Y, Peri, PL, and Seabloom, EW. "Herbivores safeguard plant diversity by reducing variability in dominance." Edited by Heard, M. Journal of Ecology 106, no. 1 (January 2018): 101-112.

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