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David Harold Harpole Jr., MD

Resident Research Director
Professor of Surgery
Associate Professor in Pathology
Professor in Pathology
Office: Hock Plaza-2424 Erwin Rd, Suite 403 Room 4017, Durham, NC 27705
Campus Mail: DUMC Box 3627 Med Ctr, Durham, NC 27710

A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.

Education and Training

  • Instructor of Surgery, Surgery, Harvard University , 1996
  • M.D., University of Virginia, 1984

Publications

Browndyke, Jeffrey N., Mary C. Wright, Rosa Yang, Ayesha Syed, John Park, Ashley Hall, Katherine Martucci, et al. “Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.” British Journal of Anaesthesia, September 14, 2021. https://doi.org/10.1016/j.bja.2021.08.012.

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Mayne, Nicholas R., Alice J. Darling, Vignesh Raman, Scott Balderson, Mark F. Berry, David H. Harpole, Thomas A. D’Amico, and Chi-Fu Jeffrey Yang. “Perioperative Outcomes and 5-year Survival After Open versus Thoracoscopic Sleeve Resection for Lung Cancer.” Seminars in Thoracic and Cardiovascular Surgery 33, no. 2 (June 2021): 522–30. https://doi.org/10.1053/j.semtcvs.2020.08.013.

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Tong, Betty C., Lin Gu, Xiaofei Wang, Dennis A. Wigle, Joseph D. Phillips, David H. Harpole, Jacob A. Klapper, Thomas Sporn, Neal E. Ready, and Thomas A. D’Amico. “Perioperative outcomes of pulmonary resection after neoadjuvant pembrolizumab in patients with non-small cell lung cancer.” J Thorac Cardiovasc Surg, April 9, 2021. https://doi.org/10.1016/j.jtcvs.2021.02.099.

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Raman, Vignesh, Oliver K. Jawitz, Chi-Fu Jeffrey Yang, Soraya L. Voigt, Thomas A. D’Amico, David H. Harpole, and Betty C. Tong. “The effect of extent of resection on outcomes in patients with limited stage small cell lung cancer.” In The Journal of Thoracic and Cardiovascular Surgery, 161:1484-1492.e5, 2021. https://doi.org/10.1016/j.jtcvs.2020.02.135.

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Farrow, Norma E., Vignesh Raman, Oliver K. Jawitz, Soraya L. Voigt, Betty C. Tong, David H. Harpole, and Thomas A. D’Amico. “Impact of Age on Surgical Outcomes for Locally Advanced Esophageal Cancer.” Ann Thorac Surg 111, no. 3 (March 2021): 996–1003. https://doi.org/10.1016/j.athoracsur.2020.06.055.

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Terrando, Niccolò, John J. Park, Michael Devinney, Cliburn Chan, Mary Cooter, Pallavi Avasarala, Joseph P. Mathew, et al. “Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.” Scientific Reports 11, no. 1 (February 4, 2021): 3047. https://doi.org/10.1038/s41598-021-82606-5.

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Rhodin, Kristen E., Vignesh Raman, Oliver K. Jawitz, Soraya L. Voigt, Norma E. Farrow, David H. Harpole, Betty C. Tong, and Thomas A. D’Amico. “Patterns of Use of Induction Therapy for T2N0 Esophageal Cancer.” Ann Thorac Surg 111, no. 2 (February 2021): 440–47. https://doi.org/10.1016/j.athoracsur.2020.05.089.

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VanDusen, Keith W., Yi-Ju Li, Victor Cai, Ashley Hall, Sarah Hiles, J Will Thompson, M Arthur Moseley, et al. “Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.” J Alzheimers Dis 80, no. 3 (2021): 1281–97. https://doi.org/10.3233/JAD-201544.

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Raman, Vignesh, Oliver K. Jawitz, Soraya L. Voigt, Kristen E. Rhodin, Thomas A. D’Amico, David H. Harpole, Chi-Fu Jeffrey Yang, and Betty C. Tong. “The Effect of Tumor Size and Histologic Findings on Outcomes After Segmentectomy vs Lobectomy for Clinically Node-Negative Non-Small Cell Lung Cancer.” Chest 159, no. 1 (January 2021): 390–400. https://doi.org/10.1016/j.chest.2020.06.066.

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Rucker, A Justin, Vignesh Raman, Oliver K. Jawitz, Soraya L. Voigt, Betty C. Tong, Thomas A. D’Amico, and David H. Harpole. “Effect of Lymph Node Assessment on Outcomes in Surgery for Limited Stage Small Cell Lung Cancer.” Ann Thorac Surg 110, no. 6 (December 2020): 1854–60. https://doi.org/10.1016/j.athoracsur.2020.04.117.

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