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David Harold Harpole Jr., MD

Resident Research Director
Professor of Surgery
Associate Professor in Pathology
Professor in Pathology
Office: Hock Plaza-2424 Erwin Rd, Suite 403 Room 4017, Durham, NC 27705
Campus Mail: DUMC Box 3627 Med Ctr, Durham, NC 27710

A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.

Education and Training

  • Instructor of Surgery, Surgery, Harvard University , 1996
  • M.D., University of Virginia, 1984

Publications

Welp, Annalyn M., Sarah E. Abbott, Pamela Samson, Robert B. Cameron, Lorraine D. Cornwell, David Harpole, and Drew Moghanaki. “The Quality of Peer-Reviewed Publications on Surgery for Early Stage Lung Cancer Within the Veterans Health Administration.” Semin Thorac Cardiovasc Surg, May 17, 2020. https://doi.org/10.1053/j.semtcvs.2020.04.004.

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Fudim, Marat, Yawar J. Qadri, Nathan H. Waldron, Richard L. Boortz-Marx, Arun Ganesh, Chetan B. Patel, Mihai V. Podgoreanu, et al. “Stellate Ganglion Blockade for the Treatment of Refractory Ventricular Arrhythmias.” Jacc Clin Electrophysiol 6, no. 5 (May 2020): 562–71. https://doi.org/10.1016/j.jacep.2019.12.017.

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Raman, Vignesh, Oliver K. Jawitz, Chi-Fu J. Yang, Soraya L. Voigt, Anthony W. Kim, Betty C. Tong, Thomas A. D’Amico, and David H. Harpole. “The influence of adjuvant therapy on survival in patients with indeterminate margins following surgery for non-small cell lung cancer.” J Thorac Cardiovasc Surg 159, no. 5 (May 2020): 2030-2040.e4. https://doi.org/10.1016/j.jtcvs.2019.09.075.

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Raman, Vignesh, Oliver K. Jawitz, Soraya L. Voigt, Chi-Fu J. Yang, Thomas A. D’Amico, and David H. Harpole. “The Role of Adjuvant Therapy in Patients With Margin-Positive (R1) Esophagectomy: A National Analysis.” J Surg Res 249 (May 2020): 82–90. https://doi.org/10.1016/j.jss.2019.11.035.

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Raman, Vignesh, Oliver K. Jawitz, Soraya L. Voigt, Chi-Fu J. Yang, Hanghang Wang, David H. Harpole, and Thomas A. D’Amico. “Effect of time to surgery on outcomes in stage I esophageal adenocarcinoma.” J Thorac Cardiovasc Surg 159, no. 4 (April 2020): 1626-1635.e1. https://doi.org/10.1016/j.jtcvs.2019.09.123.

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Raman, Vignesh, Oliver K. Jawitz, Chi-Fu Jeffrey Yang, Soraya L. Voigt, Thomas A. D’Amico, David H. Harpole, and Betty C. Tong. “The effect of extent of resection on outcomes in patients with limited stage small cell lung cancer.” In J Thorac Cardiovasc Surg, 2020. https://doi.org/10.1016/j.jtcvs.2020.02.135.

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Nobuhara, Chloe K., W Michael Bullock, Thomas Bunning, Brian Colin, Mary Cooter, Michael J. Devinney, Michael N. Ferrandino, et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol, March 20, 2020. https://doi.org/10.1007/s00415-020-09797-1.

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Raman, Vignesh, Oliver K. Jawitz, Soraya L. Voigt, Chi-Fu J. Yang, David H. Harpole, Thomas A. D’Amico, and Matthew G. Hartwig. “The effect of age on survival after endoscopic resection versus surgery for T1a esophageal cancer.” In J Thorac Cardiovasc Surg, 2019. https://doi.org/10.1016/j.jtcvs.2019.11.050.

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Raman, Vignesh, Oliver K. Jawitz, Chi-Fu J. Yang, Soraya L. Voigt, Betty C. Tong, Thomas A. D’Amico, and David H. Harpole. “Outcomes for Surgery in Large Cell Lung Neuroendocrine Cancer.” J Thorac Oncol 14, no. 12 (December 2019): 2143–51. https://doi.org/10.1016/j.jtho.2019.09.005.

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Raman, Vignesh, Oliver K. Jawitz, Chi-Fu J. Yang, Soraya L. Voigt, Hanghang Wang, Thomas A. D’Amico, David H. Harpole, and Betty C. Tong. “Outcomes of surgery versus chemoradiotherapy in patients with clinical or pathologic stage N3 non-small cell lung cancer.” J Thorac Cardiovasc Surg 158, no. 6 (December 2019): 1680-1692.e2. https://doi.org/10.1016/j.jtcvs.2019.08.033.

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