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David Harold Harpole Jr., MD

Resident Research Director
Professor of Surgery
Associate Professor in Pathology
Professor in Pathology
Office: Hock Plaza-2424 Erwin Rd, Suite 403 Room 4017, Durham, NC 27705
Campus Mail: DUMC Box 3627 Med Ctr, Durham, NC 27710

A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.

Education and Training

  • Instructor of Surgery, Surgery, Harvard University , 1996
  • M.D., University of Virginia, 1984

Publications

Heymach, John V., Tetsuya Mitsudomi, David Harpole, Mike Aperghis, Stephanie Jones, Helen Mann, Tamer M. Fouad, and Martin Reck. “Design and Rationale for a Phase III, Double-Blind, Placebo-Controlled Study of Neoadjuvant Durvalumab + Chemotherapy Followed by Adjuvant Durvalumab for the Treatment of Patients With Resectable Stages II and III non-small-cell Lung Cancer: The AEGEAN Trial.” Clinical Lung Cancer 23, no. 3 (May 2022): e247–51. https://doi.org/10.1016/j.cllc.2021.09.010.

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Rucker, A Justin, Vignesh Raman, Oliver K. Jawitz, Kristen E. Rhodin, Betty C. Tong, David H. Harpole, and Thomas A. D’Amico. “Impact of Time to Endoscopic Resection on Outcomes for Stage I Esophageal Adenocarcinoma.” Ann Thorac Surg 113, no. 3 (March 2022): 942–48. https://doi.org/10.1016/j.athoracsur.2021.04.001.

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Raman, Vignesh, Oliver K. Jawitz, Norma E. Farrow, Soraya L. Voigt, Kristen E. Rhodin, Chi-Fu J. Yang, Megan C. Turner, Thomas A. D’Amico, David H. Harpole, and Betty C. Tong. “The Relationship Between Lymph Node Ratio and Survival Benefit With Adjuvant Chemotherapy in Node-positive Esophageal Adenocarcinoma.” Ann Surg 275, no. 3 (March 1, 2022): e562–67. https://doi.org/10.1097/SLA.0000000000004150.

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Tong, Betty C., Lin Gu, Xiaofei Wang, Dennis A. Wigle, Joseph D. Phillips, David H. Harpole, Jacob A. Klapper, Thomas Sporn, Neal E. Ready, and Thomas A. D’Amico. “Perioperative outcomes of pulmonary resection after neoadjuvant pembrolizumab in patients with non-small cell lung cancer.” J Thorac Cardiovasc Surg 163, no. 2 (February 2022): 427–36. https://doi.org/10.1016/j.jtcvs.2021.02.099.

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Berger, Miles, Jeffrey N. Browndyke, Mary Cooter Wright, Chloe Nobuhara, Melody Reese, Leah Acker, W Michael Bullock, et al. “Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.” Ann Clin Transl Neurol 9, no. 2 (February 2022): 155–70. https://doi.org/10.1002/acn3.51499.

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Rucker, A Justin, Vignesh Raman, Oliver K. Jawitz, Soraya L. Voigt, David H. Harpole, Thomas A. D’Amico, and Betty C. Tong. “The Impact of Adjuvant Therapy on Survival After Esophagectomy for Node-negative Esophageal Adenocarcinoma.” Ann Surg 275, no. 2 (February 1, 2022): 348–55. https://doi.org/10.1097/SLA.0000000000003886.

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Browndyke, Jeffrey N., Mary C. Wright, Rosa Yang, Ayesha Syed, John Park, Ashley Hall, Katherine Martucci, et al. “Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.” Br J Anaesth 127, no. 6 (December 2021): 917–28. https://doi.org/10.1016/j.bja.2021.08.012.

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Raman, Vignesh, Oliver K. Jawitz, Chi-Fu Jeffrey Yang, Soraya L. Voigt, Thomas A. D’Amico, David H. Harpole, and Betty C. Tong. “The effect of extent of resection on outcomes in patients with limited stage small cell lung cancer.” In J Thorac Cardiovasc Surg, 161:1484-1492.e5, 2021. https://doi.org/10.1016/j.jtcvs.2020.02.135.

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Farrow, Norma E., Vignesh Raman, Oliver K. Jawitz, Soraya L. Voigt, Betty C. Tong, David H. Harpole, and Thomas A. D’Amico. “Impact of Age on Surgical Outcomes for Locally Advanced Esophageal Cancer.” Ann Thorac Surg 111, no. 3 (March 2021): 996–1003. https://doi.org/10.1016/j.athoracsur.2020.06.055.

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Terrando, Niccolò, John J. Park, Michael Devinney, Cliburn Chan, Mary Cooter, Pallavi Avasarala, Joseph P. Mathew, et al. “Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults.” Sci Rep 11, no. 1 (February 4, 2021): 3047. https://doi.org/10.1038/s41598-021-82606-5.

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