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David Harold Harpole Jr., MD

Resident Research Director
Professor of Surgery
Associate Professor in Pathology
Professor in Pathology
Office: Hock Plaza-2424 Erwin Rd, Suite 403 Room 4017, Durham, NC 27705
Campus Mail: DUMC Box 3627 Med Ctr, Durham, NC 27710

A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.

Education and Training

  • Instructor of Surgery, Surgery, Harvard University , 1996
  • M.D., University of Virginia, 1984

Publications

Rhodin, Kristen E., Vignesh Raman, Oliver K. Jawitz, Betty C. Tong, David H. Harpole, and Thomas A. D’Amico. “The Effect of Timing of Adjuvant Therapy on Survival After Esophagectomy.” Ann Thorac Surg 110, no. 3 (September 2020): 1023–29. https://doi.org/10.1016/j.athoracsur.2020.03.040.

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Bueno, Raphael, William G. Richards, David H. Harpole, Karla V. Ballman, Ming-Sound Tsao, Zhengming Chen, Xiaofei Wang, et al. “Multi-institutional prospective validation of prognostic mRNA signatures in early stage squamous lung cancer (Alliance).” J Thorac Oncol, July 24, 2020. https://doi.org/10.1016/j.jtho.2020.07.005.

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Nobuhara, Chloe K., W Michael Bullock, Thomas Bunning, Brian Colin, Mary Cooter, Michael J. Devinney, Michael N. Ferrandino, et al. “A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults.” J Neurol 267, no. 7 (July 2020): 2002–6. https://doi.org/10.1007/s00415-020-09797-1.

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Farrow, Norma E., Selena J. An, Paul J. Speicher, David H. Harpole, Thomas A. D’Amico, Jacob A. Klapper, Matthew G. Hartwig, and Betty C. Tong. “Disparities in guideline-concordant treatment for node-positive, non-small cell lung cancer following surgery.” In J Thorac Cardiovasc Surg, 160:261-271.e1, 2020. https://doi.org/10.1016/j.jtcvs.2019.10.102.

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Raman, Vignesh, Oliver K. Jawitz, Soraya L. Voigt, Chi-Fu J. Yang, David H. Harpole, Thomas A. D’Amico, and Matthew G. Hartwig. “The effect of age on survival after endoscopic resection versus surgery for T1a esophageal cancer.” In J Thorac Cardiovasc Surg, 160:295-302.e3, 2020. https://doi.org/10.1016/j.jtcvs.2019.11.050.

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Rucker, A Justin, Vignesh Raman, Oliver K. Jawitz, Soraya L. Voigt, Betty C. Tong, Thomas A. D’Amico, and David H. Harpole. “Effect of Lymph Node Assessment on Outcomes in Surgery for Limited Stage Small Cell Lung Cancer.” Ann Thorac Surg, June 13, 2020. https://doi.org/10.1016/j.athoracsur.2020.04.117.

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Welp, Annalyn M., Sarah E. Abbott, Pamela Samson, Robert B. Cameron, Lorraine D. Cornwell, David Harpole, and Drew Moghanaki. “The Quality of Peer-Reviewed Publications on Surgery for Early Stage Lung Cancer Within the Veterans Health Administration.” Semin Thorac Cardiovasc Surg, May 17, 2020. https://doi.org/10.1053/j.semtcvs.2020.04.004.

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Fudim, Marat, Yawar J. Qadri, Nathan H. Waldron, Richard L. Boortz-Marx, Arun Ganesh, Chetan B. Patel, Mihai V. Podgoreanu, et al. “Stellate Ganglion Blockade for the Treatment of Refractory Ventricular Arrhythmias.” Jacc Clin Electrophysiol 6, no. 5 (May 2020): 562–71. https://doi.org/10.1016/j.jacep.2019.12.017.

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Raman, Vignesh, Oliver K. Jawitz, Chi-Fu J. Yang, Soraya L. Voigt, Anthony W. Kim, Betty C. Tong, Thomas A. D’Amico, and David H. Harpole. “The influence of adjuvant therapy on survival in patients with indeterminate margins following surgery for non-small cell lung cancer.” J Thorac Cardiovasc Surg 159, no. 5 (May 2020): 2030-2040.e4. https://doi.org/10.1016/j.jtcvs.2019.09.075.

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Raman, Vignesh, Oliver K. Jawitz, Soraya L. Voigt, Chi-Fu J. Yang, Thomas A. D’Amico, and David H. Harpole. “The Role of Adjuvant Therapy in Patients With Margin-Positive (R1) Esophagectomy: A National Analysis.” J Surg Res 249 (May 2020): 82–90. https://doi.org/10.1016/j.jss.2019.11.035.

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