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David Harold Harpole Jr., MD

Resident Research Director
Professor of Surgery
Associate Professor in Pathology
Office: Hock Plaza-2424 Erwin Rd, Suite 403 Room 4017, Durham, NC 27705
Campus Mail: DUMC Box 3627 Med Ctr, Durham, NC 27710

A. Non-small cell lung cancer
1. Evaluation of serum and tissue molecular biologic markers of recurrence in patients with a localize non-small cell lung cancer.
2. Molecular biologic staging of lymph nodes in patients with non-small cell lung cancer.
3. The evaluation of the clonality of metastatic tumors in patients with non-small cell lung cancer.

B. Clinical research activities
1. Creation of a prospective database for the Duke Thoracic Oncology Program.
2. A cost and satisfaction evaluation of thoracoscopy and open thoracotomy in patients.
3. Development of risk associated models of morbidity in patients undergoing general thoracic surgery procedures: The VA Cooperative Surgical Risk Study
4. A member of the Duke Gastrointestinal Malignancy Research Committee, developing esophageal cancer treatment protocols and outcome studies.

Education and Training

  • Instructor of Surgery, Surgery, Harvard University, 1996
  • M.D., University of Virginia, 1984

Publications

Yang, C-FJ, McSherry, F, Mayne, NR, Wang, X, Berry, MF, Tong, B, Harpole, DH, D'Amico, TA, Christensen, JD, Ready, NE, and Klapper, JA. "Surgical Outcomes After Neoadjuvant Chemotherapy and Ipilimumab for Non-Small-Cell Lung Cancer." The Annals of thoracic surgery (December 16, 2017).

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Yi, JS, Ready, N, Healy, P, Dumbauld, C, Osborne, R, Berry, M, Shoemaker, D, Clarke, J, Crawford, J, Tong, B, Harpole, D, D'Amico, TA, McSherry, F, Dunphy, F, McCall, SJ, Christensen, JD, Wang, X, and Weinhold, KJ. "Immune Activation in Early-Stage Non-Small Cell Lung Cancer Patients Receiving Neoadjuvant Chemotherapy Plus Ipilimumab." Clinical cancer research : an official journal of the American Association for Cancer Research 23, no. 24 (December 2017): 7474-7482.

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Boyer, MJ, Williams, CD, Harpole, DH, Onaitis, MW, Kelley, MJ, and Salama, JK. "Improved Survival of Stage I Non-Small Cell Lung Cancer: A VA Central Cancer Registry Analysis." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 12, no. 12 (December 2017): 1814-1823.

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Anderson, KL, Mulvihill, MS, Speicher, PJ, Yerokun, BA, Gulack, BC, Nussbaum, DP, Harpole, DH, D'Amico, TA, Berry, MF, and Hartwig, MG. "Adjuvant Chemotherapy Does Not Confer Superior Survival in Patients With Atypical Carcinoid Tumors." The Annals of thoracic surgery 104, no. 4 (October 2017): 1221-1230.

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Yang, C-FJ, Kumar, A, Klapper, JA, Hartwig, MG, Tong, BC, Harpole, DH, Berry, MF, and D'Amico, TA. "A National Analysis of Long-term Survival Following Thoracoscopic Versus Open Lobectomy for Stage I Non-small-cell Lung Cancer." Annals of surgery (August 9, 2017).

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Yerokun, BA, Yang, C-FJ, Gulack, BC, Li, X, Mulvihill, MS, Gu, L, Wang, X, Harpole, DH, D'Amico, TA, Berry, MF, and Hartwig, MG. "A national analysis of wedge resection versus stereotactic body radiation therapy for stage IA non-small cell lung cancer." The Journal of thoracic and cardiovascular surgery 154, no. 2 (August 2017): 675-686.e4.

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Yao, XI, Wang, X, Speicher, PJ, Hwang, ES, Cheng, P, Harpole, DH, Berry, MF, Schrag, D, and Pang, HH. "Reporting and Guidelines in Propensity Score Analysis: A Systematic Review of Cancer and Cancer Surgical Studies." JNCI Journal of the National Cancer Institute 109, no. 8 (August 2017). (Review)

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"Discussion." The Journal of Thoracic and Cardiovascular Surgery 153, no. 6 (June 2017): 1576-1578.

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Yang, C-FJ, Chan, DY, Speicher, PJ, Gulack, BC, Tong, BC, Hartwig, MG, Kelsey, CR, D'Amico, TA, Berry, MF, and Harpole, DH. "Surgery Versus Optimal Medical Management for N1 Small Cell Lung Cancer." The Annals of thoracic surgery 103, no. 6 (June 2017): 1767-1772.

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Yang, C-FJ, Chan, DY, Shah, SA, Yerokun, BA, Wang, XF, D'Amico, TA, Berry, MF, and Harpole, DH. "Long-term Survival After Surgery Compared With Concurrent Chemoradiation for Node-negative Small Cell Lung Cancer." Annals of surgery (May 4, 2017).

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