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David Charles Montefiori, PhD

Professor of Surgery
Office: Surgical Oncology Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

Dr. Montefiori is Professor and Director of the Laboratory for AIDS Vaccine Research and Development in the Department of Surgery, Division of Surgical Sciences, Duke University Medical Center. His major research interests are viral immunology and AIDS vaccine development, with a special emphasis on neutralizing antibodies. One of his highest priorities is to identify immunogens that generate broadly cross-reactive neutralizing antibodies for inclusion in HIV vaccines.  Many aspects of the neutralizing antibody response are studied in his laboratory, including mechanisms of neutralization and escape, epitope diversity among genetic subtypes and geographic origins, ontogeny of broadly neutralizing antibody responses and computationally-assisted vaccine design. Over the years he has explored multiple types of assays for neutralizing antibodies and other potential antiviral antibodies, focusing on assay optimization, standardization, validation and high throughput. The scope of research covers HIV-infected individuals and nonhuman primate models of simian immunodeficiency virus (SIV) and simian-human immunodeficiency virus (SHIV) infection.  Dr. Montefiori also directs a large AIDS vaccine immune monitoring program, which operates in compliance with Good Clinical Laboratory Practice and has served as a national and international resource for standardized assessments of neutralizing antibody responses in preclinical and clinical trials of candidate AIDS vaccines since 1988. In 2002 he chaired the Antibody Laboratory Standardization Working Group that assisted in the design of the Global HIV Vaccine Enterprise Strategic Plan for HIV vaccines. He currently directs the Core Neutralizing Antibody Laboratories for the HIV Vaccine Clinical Trials Network (HVTN), the NIH Preclinical HIV-1 Vaccine Program and the Center for HIV/AIDS Vaccine Immunology- Immunogen Design (CHAVI-ID). He also directs a large Comprehensive Antibody Vaccine Immune Monitoring Consortium (CAVIMC) as part of the Bill and Melinda Gates Foundation's Collaboration for AIDS Vaccine Discovery (CAVD). He has published over 500 original research papers that have helped shape the scientific rationale for antibody-based HIV-1 vaccines.

Education and Training

  • Ph.D., Clemson University, 1982

Publications

Cai, Hui, Rou-Shu Zhang, Jared Orwenyo, John Giddens, Qiang Yang, Celia C. LaBranche, David C. Montefiori, and Lai-Xi Wang. “Synthetic HIV V3 Glycopeptide Immunogen Carrying a N334 N-Glycan Induces Glycan-Dependent Antibodies with Promiscuous Site Recognition.” J Med Chem 61, no. 22 (November 21, 2018): 10116–25. https://doi.org/10.1021/acs.jmedchem.8b01290.

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LaBranche, Celia C., Andrew T. McGuire, Matthew D. Gray, Shay Behrens, Peter D. Kwong, Xuejun Chen, Tongqing Zhou, et al. “HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies.” Plos Pathog 14, no. 11 (November 2018): e1007431. https://doi.org/10.1371/journal.ppat.1007431.

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Himes, Jonathon E., Ria Goswami, Riley J. Mangan, Amit Kumar, Thomas L. Jeffries, Joshua A. Eudailey, Holly Heimsath, et al. “Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys.” Mucosal Immunol 11, no. 6 (November 2018): 1716–26. https://doi.org/10.1038/s41385-018-0067-7.

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Purwar, Mansi, Jonathan K. Pokorski, Pranveer Singh, Sanchari Bhattacharyya, Heather Arendt, Joanne DeStefano, Celia C. La Branche, David C. Montefiori, M. G. Finn, and Raghavan Varadarajan. “Design, display and immunogenicity of HIV1 gp120 fragment immunogens on virus-like particles.” Vaccine 36, no. 42 (October 8, 2018): 6345–53. https://doi.org/10.1016/j.vaccine.2018.07.032.

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Pollara, Justin, Dorothy I. Jones, Tori Huffman, Maria Dennis, Grace Li, Derrick Goodman, R Whitney Edwards, et al. “Bridging Vaccine-induced Antibody Responses in Rabbit and Rhesus Macaque Animal Models.” In Aids Research and Human Retroviruses, 34:129–129. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Dukhovlinova, Elena, Alexey Masharsky, Aleksandra Vasileva, Alessandro Porrello, Shuntai Zhou, Olga Toussova, Sergei Verevochkin, et al. “Characterization of the Transmitted Virus in an Ongoing HIV-1 Epidemic Driven by Injecting Drug Use.” Aids Res Hum Retroviruses 34, no. 10 (October 2018): 867–78. https://doi.org/10.1089/AID.2017.0313.

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Bonsignori, Mattia, Eric Scott, Kevin Wiehe, David Easterhoff, S Munir Alam, Kwan-Ki Hwang, David C. Montefiori, et al. “Dual Maturation Pathways from the Unmutated Common Ancestor of HIV-1 Envelope Broadly Neutralizing Antibodies Overcome Glycan Barriers.” In Aids Research and Human Retroviruses, 34:111–111. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Behrens, Shay, Celia C. LaBranche, Tongqing Zhou, Kevin Wiehe, Mattia Bonsignori, Quentin J. Sattentau, Amanda Eaton, et al. “Germline-targeting and Reverse Engineering to Elicit CH235.12 Lineage bNAbs.” In Aids Research and Human Retroviruses, 34:116–116. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Kimpel, Janine, C Anika Bresk, Tamara Hofer, Sarah Wilmschen, Marina Krismer, Anja Beierfuss, Gregory Effantin, et al. “HIV Neutralizing Antibodies Induced by Native-like Envelope Trimers Incorporated Into a Rhabdoviral Vector Vaccine.” In Aids Research and Human Retroviruses, 34:324–324. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

Verkoczy, Laurent, Chuancang Jiang, Raiees Andrabi, Jinsong Zhang, Amanda Newman, Devin Sok, Ge Song, et al. “Mechanistic Insights Into Vaccine Induction of V2 Apex-directed, Heterologous Tier 2 Neutralizing Responses in CH103 UCA Knock-in Mice.” In Aids Research and Human Retroviruses, 34:110–110. MARY ANN LIEBERT, INC, 2018.

Scholars@Duke

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