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Dani Paul Bolognesi, PhD

Professor Emeritus of Surgery
Office: 204 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 3704 Med Ctr, Durham, NC 27710

Dr. Dani P. Bolognesi is the Director of the Center for AIDS Research. This is a comprehensive program, one of 11 nationally; that includes basic research, clinical research and patient care. Basic and clinical research programs are tightly interwoven in areas and include basic molecular and viral biology, vaccine research and novel approaches for therapy that include genetic therapy and immune reconstitution.

Dr. Bolognesi also heads a research team that focuses on immune mechanisms that control HIV replication and pathogenesis. This group of investigators also represents the Central Immunology Laboratory for NIH sponsored AIDS Vaccine Clinical Trials.

Recently Duke University Medical Center has initiated a multidisciplinary program focused on harnessing the immune system to combat infectious diseases, autoimmune disorders and cancer. Dr. Bolognesi and Dr. Barton F. Haynes of the Department of Medicine are Co-Directors of the program which has been designated as the Human Vaccine Institute.

Dr. Bolognesi is also Vice Chairman of Research and Development for the Department of Surgery.

Education and Training

  • Ph.D., Duke University, 1967

Selected Grants

Publications

Bolognesi, DP. "Basic science in a department of surgery." Annals of surgery 238, no. 6 Suppl (December 2003): S33-.

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LaBranche, CC, Galasso, G, Moore, JP, Bolognesi, DP, Hirsch, MS, and Hammer, SM. "HIV fusion and its inhibition." Antiviral Res 50, no. 2 (May 2001): 95-115. (Review)

Scholars@Duke

Chen, CH, Greenberg, ML, Bolognesi, DP, and Matthews, TJ. "Monoclonal antibodies that bind to the core of fusion-active glycoprotein 41." AIDS Res Hum Retroviruses 16, no. 18 (December 10, 2000): 2037-2041.

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Markert, ML, Hicks, CB, Bartlett, JA, Harmon, JL, Hale, LP, Greenberg, ML, Ferrari, G, Ottinger, J, Boeck, A, Kloster, AL, McLaughlin, TM, Bleich, KB, Ungerleider, RM, Lyerly, HK, Wilkinson, WE, Rousseau, FS, Heath-Chiozzi, ME, Leonard, JM, Haase, AT, Shaw, GM, Bucy, RP, Douek, DC, Koup, RA, Haynes, BF, Bolognesi, DP, and Weinhold, KJ. "Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection." AIDS research and human retroviruses 16, no. 5 (March 2000): 403-413.

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Tyler, DS, Stanley, SD, Bartlett, JA, Bolognesi, DP, and Weinhold, KJ. "Lymphokine-activated killer (LAK) cell anti-HIV-1 ADCC reactivity: a potential strategy for reduction of virus-infected cellular reservoirs." J Surg Res 79, no. 2 (October 1998): 115-120.

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Langlois, AJ, Desrosiers, RC, Lewis, MG, KewalRamani, VN, Littman, DR, Zhou, JY, Manson, K, Wyand, MS, Bolognesi, DP, and Montefiori, DC. "Neutralizing antibodies in sera from macaques immunized with attenuated simian immunodeficiency virus." J Virol 72, no. 8 (August 1998): 6950-6955.

Scholars@Duke

Montefiori, DC, Reimann, KA, Wyand, MS, Manson, K, Lewis, MG, Collman, RG, Sodroski, JG, Bolognesi, DP, and Letvin, NL. "Neutralizing antibodies in sera from macaques infected with chimeric simian-human immunodeficiency virus containing the envelope glycoproteins of either a laboratory-adapted variant or a primary isolate of human immunodeficiency virus type 1." J Virol 72, no. 4 (April 1998): 3427-3431.

Scholars@Duke

Montefiori, DC, Collman, RG, Fouts, TR, Zhou, JY, Bilska, M, Hoxie, JA, Moore, JP, and Bolognesi, DP. "Evidence that antibody-mediated neutralization of human immunodeficiency virus type 1 by sera from infected individuals is independent of coreceptor usage." J Virol 72, no. 3 (March 1998): 1886-1893.

Scholars@Duke

Bolognesi, DP, and Matthews, TJ. "HIV vaccines. Viral envelope fails to deliver?." Nature 391, no. 6668 (February 1998): 638-639.

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Pilgrim, AK, Pantaleo, G, Cohen, OJ, Fink, LM, Zhou, JY, Zhou, JT, Bolognesi, DP, Fauci, AS, and Montefiori, DC. "Neutralizing antibody responses to human immunodeficiency virus type 1 in primary infection and long-term-nonprogressive infection." J Infect Dis 176, no. 4 (October 1997): 924-932.

Scholars@Duke

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