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Dani Paul Bolognesi, PhD

Professor Emeritus of Surgery
Division: 
Surgical Sciences
Office: 204 Surg Oncol Res Fac, Durham, NC 27710
Campus Mail: DUMC Box 3704 Med Ctr, Durham, NC 27710

Dr. Dani P. Bolognesi is the Director of the Center for AIDS Research. This is a comprehensive program, one of 11 nationally; that includes basic research, clinical research and patient care. Basic and clinical research programs are tightly interwoven in areas and include basic molecular and viral biology, vaccine research and novel approaches for therapy that include genetic therapy and immune reconstitution.

Dr. Bolognesi also heads a research team that focuses on immune mechanisms that control HIV replication and pathogenesis. This group of investigators also represents the Central Immunology Laboratory for NIH sponsored AIDS Vaccine Clinical Trials.

Recently Duke University Medical Center has initiated a multidisciplinary program focused on harnessing the immune system to combat infectious diseases, autoimmune disorders and cancer. Dr. Bolognesi and Dr. Barton F. Haynes of the Department of Medicine are Co-Directors of the program which has been designated as the Human Vaccine Institute.

Education and Training

  • Ph.D., Duke University, 1967

Selected Grants

Publications

Desjardins, A, Gromeier, M, Herndon, JE, Beaubier, N, Bolognesi, DP, Friedman, AH, Friedman, HS, McSherry, F, Muscat, AM, Nair, S, Peters, KB, Randazzo, D, Sampson, JH, Vlahovic, G, Harrison, WT, McLendon, RE, Ashley, D, and Bigner, DD. "Recurrent Glioblastoma Treated with Recombinant Poliovirus." The New England Journal of Medicine 379, no. 2 (July 2018): 150-161.

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Gallo, RC, Fischinger, PJ, and Bolognesi, DP. "Vaccine strategies against the human retroviruses associated with AIDS." In Vaccine Intervention Against Virus-Induced Tumour: Leukaemia and Lymphoma Research, 81-91. January 7, 2016.

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Jazwinski, SM, and Yashin, AI. "Introduction." VII-XII. 2014.

Scholars@Duke

Lu, R-J, Tucker, JA, Pickens, J, Ma, Y-A, Zinevitch, T, Kirichenko, O, Konoplev, V, Kuznetsova, S, Sviridov, S, Brahmachary, E, Khasanov, A, Mikel, C, Yang, Y, Liu, C, Wang, J, Freel, S, Fisher, S, Sullivan, A, Zhou, J, Stanfield-Oakley, S, Baker, B, Sailstad, J, Greenberg, M, Bolognesi, D, Bray, B, Koszalka, B, Jeffs, P, Jeffries, C, Chucholowski, A, and Sexton, C. "Heterobiaryl human immunodeficiency virus entry inhibitors." Journal of Medicinal Chemistry 52, no. 14 (July 2009): 4481-4487.

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Lu, R-J, Tucker, JA, Zinevitch, T, Kirichenko, O, Konoplev, V, Kuznetsova, S, Sviridov, S, Pickens, J, Tandel, S, Brahmachary, E, Yang, Y, Wang, J, Freel, S, Fisher, S, Sullivan, A, Zhou, J, Stanfield-Oakley, S, Greenberg, M, Bolognesi, D, Bray, B, Koszalka, B, Jeffs, P, Khasanov, A, Ma, Y-A, Jeffries, C, Liu, C, Proskurina, T, Zhu, T, Chucholowski, A, Li, R, and Sexton, C. "Design and synthesis of human immunodeficiency virus entry inhibitors: sulfonamide as an isostere for the alpha-ketoamide group." Journal of Medicinal Chemistry 50, no. 26 (December 4, 2007): 6535-6544.

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Matthews, T, Salgo, M, Greenberg, M, Chung, J, DeMasi, R, and Bolognesi, D. "Enfuvirtide: the first therapy to inhibit the entry of HIV-1 into host CD4 lymphocytes." Nature Reviews. Drug Discovery 3, no. 3 (March 2004): 215-225. (Review)

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Bolognesi, DP. "Basic science in a department of surgery." Annals of surgery 238, no. 6 Suppl (December 2003): S33-.

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Bolognesi, DP. "Basic science in a department of surgery." Annals of Surgery 238, no. 6 Suppl (December 1, 2003).

Scholars@Duke

LaBranche, CC, Galasso, G, Moore, JP, Bolognesi, DP, Hirsch, MS, and Hammer, SM. "HIV fusion and its inhibition." Antiviral Research 50, no. 2 (May 2001): 95-115. (Review)

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Chen, CH, Greenberg, ML, Bolognesi, DP, and Matthews, TJ. "Monoclonal antibodies that bind to the core of fusion-active glycoprotein 41." Aids Research and Human Retroviruses 16, no. 18 (December 2000): 2037-2041.

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