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Chin-Ho Chen, PhD

Professor in Surgery
Office: Sorf Bldg Room 117. South Lasalle St., Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

Education and Training

  • Assistant Professor, Microbiology, Meharry Medical College, 1998 - 2002
  • Assistant Research Professor, Surgery, Duke University, 1997 - 1998
  • Research Associate, Ctr. For Aids Research, Duke University, 1992 - 1997
  • Postdoctoral Fellow, Rheumotology, Duke University, 1991 - 1992
  • Ph.D., University of North Carolina - Chapel Hill, 1991

Publications

Niwa, Kanji, Naonobu Tanaka, Yusei Shimomoto, Daisuke Tsuji, Sang-Yong Kim, Mareshige Kojoma, Kohji Itoh, Chin-Ho Chen, Kuo-Hsiung Lee, and Yoshiki Kashiwada. “Hyperdioxanes, dibenzo-1,4-dioxane derivatives from the roots of Hypericum ascyron.” J Nat Med 75, no. 4 (September 2021): 907–14. https://doi.org/10.1007/s11418-021-01540-y.

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Otsuki, Kouharu, Mi Zhang, Takashi Kikuchi, Minami Tsuji, Miyuko Tejima, Zi-Song Bai, Di Zhou, et al. “Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC-MS analysis and phytochemical investigation.” J Nat Med 75, no. 4 (September 2021): 1058–66. https://doi.org/10.1007/s11418-021-01551-9.

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Zhang, Mi, Kouharu Otsuki, Takashi Kikuchi, Zi-Song Bai, Di Zhou, Li Huang, Chin-Ho Chen, et al. “LC-MS Identification, Isolation, and Structural Elucidation of Anti-HIV Tigliane Diterpenoids from Wikstroemia lamatsoensis.” J Nat Prod 84, no. 8 (August 27, 2021): 2366–73. https://doi.org/10.1021/acs.jnatprod.1c00570.

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Li, Qi-Run, Yung-Yi Cheng, Lei Zhao, Xiao-Lei Huang, Xiao-Gang Jiang, Ya-Dong Cui, Susan L. Morris-Natschke, et al. “New phorbol ester derivatives as potent anti-HIV agents.” Bioorg Med Chem Lett 50 (August 14, 2021): 128319. https://doi.org/10.1016/j.bmcl.2021.128319.

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Zhao, Yu, Chin-Ho Chen, Susan L. Morris-Natschke, and Kuo-Hsiung Lee. “Design, synthesis, and structure activity relationship analysis of new betulinic acid derivatives as potent HIV inhibitors.” Eur J Med Chem 215 (April 5, 2021): 113287. https://doi.org/10.1016/j.ejmech.2021.113287.

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Feng, Da, Xiaofang Zuo, Lanlan Jing, Chin-Ho Chen, Fisayo A. Olotu, Hao Lin, Mahmoud Soliman, et al. “Design, synthesis, and evaluation of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase.” Eur J Med Chem 211 (February 5, 2021): 113063. https://doi.org/10.1016/j.ejmech.2020.113063.

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Dang, Zhao, Lei Zhu, Lan Xie, Kuo-Hsiung Lee, Faisal Malik, Zhijun Li, Li Huang, and Chin-Ho Chen. “Design and Synthesis of Quinolizidine Derivatives as Influenza Virus and HIV-1 Inhibitors.” Curr Med Chem 28, no. 24 (2021): 4995–5003. https://doi.org/10.2174/0929867328666201229121802.

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Otsuki, Kouharu, Mi Zhang, Asuka Yamamoto, Minami Tsuji, Miyuko Tejima, Zi-Song Bai, Di Zhou, et al. “Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla.” J Nat Prod 83, no. 12 (December 24, 2020): 3584–90. https://doi.org/10.1021/acs.jnatprod.0c00700.

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Otsuki, Kouharu, Wei Li, Kasumi Miura, Yoshihisa Asada, Li Huang, Chin-Ho Chen, Kuo-Hsiung Lee, and Kazuo Koike. “Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora.” J Nat Prod 83, no. 11 (November 25, 2020): 3270–77. https://doi.org/10.1021/acs.jnatprod.0c00540.

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Wang, Qiang, Yujiang Li, Liyun Zheng, Xiaowan Huang, Yanli Wang, Chin-Ho Chen, Yung-Yi Cheng, Susan L. Morris-Natschke, and Kuo-Hsiung Lee. “Novel Betulinic Acid-Nucleoside Hybrids with Potent Anti-HIV Activity.” Acs Med Chem Lett 11, no. 11 (November 12, 2020): 2290–93. https://doi.org/10.1021/acsmedchemlett.0c00414.

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