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Bruce Alan Sullenger, PhD

Joseph W. and Dorothy W. Beard Professor of Experimental Surgery, in the School of Medicine
Professor of Surgery
Associate Professor in Molecular Genetics and Microbiology
Professor of Pharmacology and Cancer Biology
Professor of Neurosurgery
Office: 1079 MSRB II, Box 103035, Durham, NC 27710
Campus Mail: DUMC Box 103035, Durham, NC 27710

The main focus of my translational research laboratory is to develop RNA based therapeutic agents for the potential treatment of a range of diseases. To this end, we have and will continue to take advantage of the fact that RNA is not just a passive carrier of genetic instructions inside of cells during the conversion of information from DNA to RNA to protein. Rather, RNA is an extremely versatile biological macromolecule. Certian RNAs can bind to specific protiens with high affinities, while others can for catalytic centers and perform enzymatic reactions. These facets of RNA coupled with the ease with which RNA can be manipulated in vitro make it a very powerful and unique therapeutic agent whose potential is largely untapped. Durring our endeavors, we plan to work closely with the members of the Molecular Therapeutics program as well as other faculty at the Duke University Medical Center to expedite the development and testing of these therapeutics.

The specific aims of my laboratory are:

1. To isolate and characterize RNA and DNA aptamers which block therapeutically relavent proteins such as those involved in cardiovascular diseases and immune modulation.

2. To develop RNA-based tumor targeting strategies for delivering siRNAs and miRNAs to tumor cells.

3. To reprogram cells using mRNA delivery.

4. To explore novel methods to control inflammation.

Education and Training

  • Ph.D., Cornell University, 1990

Selected Grants

Weight: 
-20

Publications

Lee, T. C., B. A. Sullenger, H. F. Gallardo, G. E. Ungers, and E. Gilboa. “Overexpression of RRE-derived sequences inhibits HIV-1 replication in CEM cells..” New Biol 4, no. 1 (January 1992): 66–74.

Scholars@Duke

Sullenger, B. A., H. F. Gallardo, G. E. Ungers, and E. Gilboa. “Analysis of trans-acting response decoy RNA-mediated inhibition of human immunodeficiency virus type 1 transactivation..” J Virol 65, no. 12 (December 1991): 6811–16.

Scholars@Duke

Sullenger, B. A., T. C. Lee, C. A. Smith, G. E. Ungers, and E. Gilboa. “Expression of chimeric tRNA-driven antisense transcripts renders NIH 3T3 cells highly resistant to Moloney murine leukemia virus replication..” Mol Cell Biol 10, no. 12 (December 1990): 6512–23. https://doi.org/10.1128/mcb.10.12.6512.

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Sullenger, B. A., H. F. Gallardo, G. E. Ungers, and E. Gilboa. “Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication..” Cell 63, no. 3 (November 2, 1990): 601–8. https://doi.org/10.1016/0092-8674(90)90455-n.

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Hantzopoulos, P. A., B. A. Sullenger, G. Ungers, and E. Gilboa. “Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector..” Proc Natl Acad Sci U S A 86, no. 10 (May 1989): 3519–23. https://doi.org/10.1073/pnas.86.10.3519.

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