Skip to main content

Bradley Henry Collins, MD

Medical Director, Animal Research
Associate Professor of Surgery
Office: Hanes House, Trent Drive, Durham, NC 27710
Campus Mail: DUMC Box 3512 Med Ctr, Durham, NC 27710

(1) The laboratory's primary focus is the study of the feasibility of transplanting porcine islets into primates as a treatment for type 1 diabetes mellitus. There is a severe shortage of human cadaveric pancreas donors for the 1 to 2 million type 1 diabetics in the United States. The use of human islets would further exacerbate the problem as 2 or 3 pancreases are required per recipient. In collaboration with Dr. Emmanuel Opara, an islet cell physiologist, we have purified islets from porcine pancreases, placed the islets in microcapsules, and transplanted the islets into diabetic baboons without the use of immunosuppression. Our goal is to demonstrated the utility of this system as a pre-clinical model.

(2) Recently, my laboratory has developed an interest in senescence of the liver. The project is a collaborative effort with hepatologist Dr. Don Rockey. We induce cirrhosis in young and old mice with carbon tetrachloride and then extract the intrahepatic lymphocytes. FACS technology is used to identified the lymphocyte populations and then sort them. The cytokine profile is then elucidated. We plan to use gene chip technology to assess the gene expression.

Education and Training

  • Fellow, Surgery, University of Wisconsin at Madison, 1997 - 1999
  • Chief Resident, Surgery, Duke University, 1996 - 1997
  • Senior Assistant Resident, Surgery, Duke University, 1994 - 1996
  • Research Fellow, Surgery, Duke University, 1991 - 1994
  • Junior Assistant Resident, Surgery, Duke University, 1990 - 1991
  • Intern, Surgery, Duke University, 1989 - 1990
  • M.D., Duke University, 1989
Weight: 
-20

Publications

BROOME, A. H., B. H. COLLINS, R. C. HARLAND, W. C. MEYERS, and T. N. PAPPAS. “QUALITY-OF-LIFE AFTER PANCREATIC DEBRIDEMENT.” In Gastroenterology, 108:A1214–A1214, 1995. https://doi.org/10.1016/0016-5085(95)29152-0.

Full Text

Collins, B. H., R. S. Chari, J. C. Magee, R. C. Harland, B. J. Lindman, J. S. Logan, R. R. Bollinger, W. C. Meyers, and J. L. Platt. “Immunopathology of porcine livers perfused with blood of humans with fulminant hepatic failure..” Transplant Proc 27, no. 1 (February 1995): 280–81.

Scholars@Duke

Magee, J. C., B. H. Collins, R. C. Harland, R. R. Bollinger, M. M. Frank, and J. L. Platt. “Prevention of hyperacute xenograft rejection by intravenous immunoglobulin..” Transplant Proc 27, no. 1 (February 1995).

Scholars@Duke

Collins, B. H., R. S. Chari, J. C. Magee, R. C. Harland, B. J. Lindman, J. S. Logan, R. R. Bollinger, W. C. Meyers, and J. L. Platt. “Mechanisms of injury in porcine livers perfused with blood of patients with fulminant hepatic failure..” Transplantation 58, no. 11 (December 15, 1994): 1162–71.

Scholars@Duke

Chari, R. S., B. H. Collins, J. C. Magee, J. M. DiMaio, A. D. Kirk, R. C. Harland, R. L. McCann, J. L. Platt, and W. C. Meyers. “Brief report: treatment of hepatic failure with ex vivo pig-liver perfusion followed by liver transplantation..” N Engl J Med 331, no. 4 (July 28, 1994): 234–37. https://doi.org/10.1056/NEJM199407283310404.

Full Text

Pruitt, S. K., A. D. Kirk, R. R. Bollinger, H. C. Marsh, B. H. Collins, J. L. Levin, J. R. Mault, J. S. Heinle, S. Ibrahim, and A. R. Rudolph. “The effect of soluble complement receptor type 1 on hyperacute rejection of porcine xenografts..” Transplantation 57, no. 3 (February 1994): 363–70. https://doi.org/10.1097/00007890-199402150-00009.

Full Text

Collins, B. H., M. L. Areford, M. A. Fabian, B. D. Jaffee, and R. R. Bollinger. “Brequinar sodium potentiates the effects of cyclosporine in experimental small bowel transplantation..” Transplant Proc 25, no. 3 Suppl 2 (June 1993): 37–39.

Scholars@Duke

Pages