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Bradley Henry Collins, MD

Medical Director, Animal Research
Associate Professor of Surgery
Office: Hanes House, Trent Drive, Durham, NC 27710
Campus Mail: DUMC Box 3512 Med Ctr, Durham, NC 27710

(1) The laboratory's primary focus is the study of the feasibility of transplanting porcine islets into primates as a treatment for type 1 diabetes mellitus. There is a severe shortage of human cadaveric pancreas donors for the 1 to 2 million type 1 diabetics in the United States. The use of human islets would further exacerbate the problem as 2 or 3 pancreases are required per recipient. In collaboration with Dr. Emmanuel Opara, an islet cell physiologist, we have purified islets from porcine pancreases, placed the islets in microcapsules, and transplanted the islets into diabetic baboons without the use of immunosuppression. Our goal is to demonstrated the utility of this system as a pre-clinical model.

(2) Recently, my laboratory has developed an interest in senescence of the liver. The project is a collaborative effort with hepatologist Dr. Don Rockey. We induce cirrhosis in young and old mice with carbon tetrachloride and then extract the intrahepatic lymphocytes. FACS technology is used to identified the lymphocyte populations and then sort them. The cytokine profile is then elucidated. We plan to use gene chip technology to assess the gene expression.

Education and Training

  • Fellow, Surgery, University of Wisconsin at Madison, 1997 - 1999
  • Chief Resident, Surgery, Duke University, 1996 - 1997
  • Senior Assistant Resident, Surgery, Duke University, 1994 - 1996
  • Research Fellow, Surgery, Duke University, 1991 - 1994
  • Junior Assistant Resident, Surgery, Duke University, 1990 - 1991
  • Intern, Surgery, Duke University, 1989 - 1990
  • M.D., Duke University, 1989
Weight: 
-20

Publications

D’Alessandro, A. M., J. D. Pirsch, S. J. Knechtle, J. S. Odorico, W. J. Van der Werf, B. H. Collins, Y. T. Becker, M. Kalayoglu, M. J. Armbrust, and H. W. Sollinger. “Living unrelated renal donation: the University of Wisconsin experience..” Surgery 124, no. 4 (October 1998): 604–10. https://doi.org/10.1067/msy.1998.91482.

Full Text

Pruitt, S. K., R. R. Bollinger, B. H. Collins, H. C. Marsh, J. L. Levin, A. R. Rudolph, W. M. Baldwin, and F. Sanfilippo. “Effect of continuous complement inhibition using soluble complement receptor type 1 on survival of pig-to-primate cardiac xenografts..” Transplantation 63, no. 6 (March 27, 1997): 900–902. https://doi.org/10.1097/00007890-199703270-00017.

Full Text

Odorico, J. S., Y. T. Becker, W. Van der Werf, B. Collins, A. M. D’Alessandro, S. J. Knechtle, J. D. Pirsch, and H. W. Sollinger. “Advances in pancreas transplantation: the University of Wisconsin experience..” Clin Transpl, 1997, 157–66.

Scholars@Duke

Pruitt, S. K., R. R. Bollinger, B. H. Collins, H. C. Marsh, J. L. Levin, A. R. Rudolph, W. M. Baldwin, and F. Sanfilippo. “Continuous complement (C) inhibition using soluble C receptor type 1 (sCR1): effect on hyperacute rejection (HAR) of pig-to-primate cardiac xenografts..” Transplant Proc 28, no. 2 (April 1996).

Scholars@Duke

Cotterell, A. H., B. H. Collins, W. Parker, R. C. Harland, and J. L. Platt. “The humoral immune response in humans following ex vivo perfusion of porcine livers..” Transplant Proc 28, no. 2 (April 1996).

Scholars@Duke

Magee, J. C., B. H. Collins, R. C. Harland, B. J. Lindman, R. R. Bollinger, M. M. Frank, and J. L. Platt. “Immunoglobulin prevents complement-mediated hyperacute rejection in swine-to-primate xenotransplantation..” J Clin Invest 96, no. 5 (November 1995): 2404–12. https://doi.org/10.1172/JCI118297.

Full Text

Cotterell, A. H., B. H. Collins, W. Parker, R. C. Harland, and J. L. Platt. “The humoral immune response in humans following cross-perfusion of porcine organs..” Transplantation 60, no. 8 (October 27, 1995): 861–68.

Scholars@Duke

Alvarado, C. G., A. H. Cotterell, K. R. McCurry, B. H. Collins, J. C. Magee, J. Berthold, J. S. Logan, and J. L. Platt. “Variation in the level of xenoantigen expression in porcine organs..” Transplantation 59, no. 11 (June 15, 1995): 1589–96.

Scholars@Duke

Collins, B. H., A. H. Cotterell, K. R. McCurry, C. G. Alvarado, J. C. Magee, W. Parker, and J. L. Platt. “Cardiac xenografts between primate species provide evidence for the importance of the alpha-galactosyl determinant in hyperacute rejection..” J Immunol 154, no. 10 (May 15, 1995): 5500–5510.

Scholars@Duke

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