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Bradley Henry Collins, MD

Medical Director, Animal Research
Associate Professor of Surgery
Office: Hanes House, Trent Drive, Durham, NC 27710
Campus Mail: DUMC Box 3512 Med Ctr, Durham, NC 27710

(1) The laboratory's primary focus is the study of the feasibility of transplanting porcine islets into primates as a treatment for type 1 diabetes mellitus. There is a severe shortage of human cadaveric pancreas donors for the 1 to 2 million type 1 diabetics in the United States. The use of human islets would further exacerbate the problem as 2 or 3 pancreases are required per recipient. In collaboration with Dr. Emmanuel Opara, an islet cell physiologist, we have purified islets from porcine pancreases, placed the islets in microcapsules, and transplanted the islets into diabetic baboons without the use of immunosuppression. Our goal is to demonstrated the utility of this system as a pre-clinical model.

(2) Recently, my laboratory has developed an interest in senescence of the liver. The project is a collaborative effort with hepatologist Dr. Don Rockey. We induce cirrhosis in young and old mice with carbon tetrachloride and then extract the intrahepatic lymphocytes. FACS technology is used to identified the lymphocyte populations and then sort them. The cytokine profile is then elucidated. We plan to use gene chip technology to assess the gene expression.

Education and Training

  • Fellow, Surgery, University of Wisconsin at Madison, 1997 - 1999
  • Chief Resident, Surgery, Duke University, 1996 - 1997
  • Senior Assistant Resident, Surgery, Duke University, 1994 - 1996
  • Research Fellow, Surgery, Duke University, 1991 - 1994
  • Junior Assistant Resident, Surgery, Duke University, 1990 - 1991
  • Intern, Surgery, Duke University, 1989 - 1990
  • M.D., Duke University, 1989
Weight: 
-20

Publications

Collins, B. H., J. D. Pirsch, Y. T. Becker, M. J. Hanaway, W. J. Van der Werf, A. M. D’Alessandro, S. J. Knechtle, et al. “Long-term results of liver transplantation in older patients 60 years of age and older..” Transplantation 70, no. 5 (September 15, 2000): 780–83. https://doi.org/10.1097/00007890-200009150-00012.

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Clavien, P. A., P. Baron, B. Tuttle-Newhall, and B. H. Collins. “Contralateral inflow occlusion to optimize graft volume and to reduce blood loss during parenchymal dissection in living-related liver transplantation..” Transplantation 69, no. 10 (May 27, 2000). https://doi.org/10.1097/00007890-200005270-00054.

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Becker, B. N., P. C. Brazy, Y. T. Becker, J. S. Odorico, T. J. Pintar, B. H. Collins, J. D. Pirsch, G. E. Leverson, D. M. Heisey, and H. W. Sollinger. “Simultaneous pancreas-kidney transplantation reduces excess mortality in type 1 diabetic patients with end-stage renal disease..” Kidney Int 57, no. 5 (May 2000): 2129–35. https://doi.org/10.1046/j.1523-1755.2000.00064.x.

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Collins, B. H., W. F. Kendall, H. A. Hobbs, M. D. Darrabie, and E. C. Opara. “Microcapsule stabilization with sodium sulfate pretreatment..” Transplantation 69, no. 8 (April 27, 2000): S209–S209.

Scholars@Duke

Becker, B. N., Y. T. Becker, T. J. Pintar, B. H. Collins, J. D. Pirsch, A. Friedman, H. W. Sollinger, and P. C. Brazy. “Using renal transplantation to evaluate a simple approach for predicting the impact of end-stage renal disease therapies on patient survival: observed/expected life span..” Am J Kidney Dis 35, no. 4 (April 2000): 653–59. https://doi.org/10.1016/s0272-6386(00)70012-6.

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Foley, D. P., B. R. Collins, J. C. Magee, J. L. Platt, E. Katz, R. C. Harland, W. C. Meyers, and R. S. Chari. “Bile acids in xenogeneic ex-vivo liver perfusion: function of xenoperfused livers and compatibility with human bile salts and porcine livers..” Transplantation 69, no. 2 (January 27, 2000): 242–48. https://doi.org/10.1097/00007890-200001270-00009.

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Becker, B. N., J. S. Odorico, Y. T. Becker, G. Leverson, J. C. McDermott, T. Grist, I. Sproat, et al. “Peripheral vascular disease and renal transplant artery stenosis: a reappraisal of transplant renovascular disease..” Clin Transplant 13, no. 4 (August 1999): 349–55. https://doi.org/10.1034/j.1399-0012.1999.130412.x.

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Becker, B. N., Y. T. Becker, D. M. Heisey, G. E. Leverson, B. H. Collins, J. S. Odorico, A. M. D’Alessandro, S. J. Knechtle, J. D. Pirsch, and H. W. Sollinger. “The impact of hypoalbuminemia in kidney-pancreas transplant recipients..” Transplantation 68, no. 1 (July 15, 1999): 72–75. https://doi.org/10.1097/00007890-199907150-00014.

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Becker, Y. T., M. Groshek, B. N. Becker, B. H. Collins, J. S. Odorico, M. Hanaway, J. D. Pirsch, S. J. Knechtle, A. M. D’Alessandro, and H. W. Sollinger. “A SURVEY OF MALE SEXUAL FUNCTION FOLLOWING PANCREAS TRANSPLANTATION.” Transplantation 67, no. 7 (April 1999): S174–S174. https://doi.org/10.1097/00007890-199904150-00697.

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Van der Werf, W. J., J. Odorico, A. M. D’Alessandro, S. Knechtle, Y. Becker, B. Collins, J. Pirsch, R. Hoffman, and H. W. Sollinger. “Utilization of pediatric donors for pancreas transplantation..” In Transplant Proc, 31:610–11, 1999. https://doi.org/10.1016/s0041-1345(98)01578-4.

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