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Bradley Henry Collins, MD

Medical Director, Animal Research
Associate Professor of Surgery
Office: Hanes House, Trent Drive, Durham, NC 27710
Campus Mail: DUMC Box 3512 Med Ctr, Durham, NC 27710

(1) The laboratory's primary focus is the study of the feasibility of transplanting porcine islets into primates as a treatment for type 1 diabetes mellitus. There is a severe shortage of human cadaveric pancreas donors for the 1 to 2 million type 1 diabetics in the United States. The use of human islets would further exacerbate the problem as 2 or 3 pancreases are required per recipient. In collaboration with Dr. Emmanuel Opara, an islet cell physiologist, we have purified islets from porcine pancreases, placed the islets in microcapsules, and transplanted the islets into diabetic baboons without the use of immunosuppression. Our goal is to demonstrated the utility of this system as a pre-clinical model.

(2) Recently, my laboratory has developed an interest in senescence of the liver. The project is a collaborative effort with hepatologist Dr. Don Rockey. We induce cirrhosis in young and old mice with carbon tetrachloride and then extract the intrahepatic lymphocytes. FACS technology is used to identified the lymphocyte populations and then sort them. The cytokine profile is then elucidated. We plan to use gene chip technology to assess the gene expression.

Education and Training

  • Fellow, Surgery, University of Wisconsin at Madison, 1997 - 1999
  • Chief Resident, Surgery, Duke University, 1996 - 1997
  • Senior Assistant Resident, Surgery, Duke University, 1994 - 1996
  • Research Fellow, Surgery, Duke University, 1991 - 1994
  • Junior Assistant Resident, Surgery, Duke University, 1990 - 1991
  • Intern, Surgery, Duke University, 1989 - 1990
  • M.D., Duke University, 1989
Weight: 
-20

Publications

Harris, Matt T., Pat L. Holl, Kyla M. Bennett, Brad H. Collins, Carlos E. Marroquin, John E. Scarborough, Janet E. Tuttle-Newhall, Paul C. Kuo, and Dev M. Desai. “Intra-operative aprotinin in liver transplant and renal dysfunction..” In American Journal of Transplantation, 7:473–74. BLACKWELL PUBLISHING, 2007.

Scholars@Duke

Harris, Matt T., Erin L. McCann, Dev M. Desai, Brad H. Collins, Carlos E. Marroquin, Janet E. Tuttle-Newhall, and Paul C. Kuo. “Two-daclizumab vs two-dose basiliximab in high-risk kidney and kidney-pancreas transplant..” In American Journal of Transplantation, 7:521–521. BLACKWELL PUBLISHING, 2007.

Scholars@Duke

Scarborough, John E., Ricardo Pietrobon, Carlos E. Marroquin, Janet E. Tuttle-Newhall, Paul C. Kuo, Bradley H. Collins, Dev M. Desai, and Theodore N. Pappas. “Temporal trends in early clinical outcomes and health care resource utilization for liver transplantation in the United States..” J Gastrointest Surg 11, no. 1 (January 2007): 82–88. https://doi.org/10.1007/s11605-007-0103-5.

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Hanish, S. I., R. P. Petersen, B. H. Collins, J. Tuttle-Newhall, C. E. Marroquin, P. C. Kuo, D. W. Butterly, S. R. Smith, and D. M. Desai. “Obesity predicts increased overall complications following pancreas transplantation..” Transplant Proc 37, no. 8 (October 2005): 3564–66. https://doi.org/10.1016/j.transproceed.2005.09.068.

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Marroquin, Carlos E., Erick B. Edwards, Bradley H. Collins, Dev M. Desai, Janet E. Tuttle-Newhall, and Paul C. Kuo. “Half-life analysis of pancreas and kidney transplants..” Transplantation 80, no. 2 (July 27, 2005): 272–75. https://doi.org/10.1097/01.tp.0000165094.94020.03.

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Desai, D. M., J. E. Tuttle-Newhall, B. H. Collins, D. C. Rockey, C. Marroquin, P. C. Kuo, and A. D. Smith. “Aggressive recurrent HCV liver disease following liver transplantation in the absence of any immunosuppression..” In Liver Transplantation, 11:C76–C76. JOHN WILEY & SONS INC, 2005.

Scholars@Duke

Smith, Alastair D., Diane Bai, Carlos E. Marroquin, Janet E. Tuttle-Newhall, Dev M. Desai, Bradley H. Collins, Andrew Muir, Paul C. Kuo, John McHutchison, and Don C. Rockey. “Gastrointestinal hemorrhage due to complicated gastroduodenal ulcer disease in liver transplant patients taking sirolimus..” Clin Transplant 19, no. 2 (April 2005): 250–54. https://doi.org/10.1111/j.1399-0012.2005.00332.x.

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Collins, Bradley H., Carlos E. Marroquin, Janet E. Tuttle-Newhall, Paul C. Kuo, Glenn M. Preminger, and David W. Butterly. “Acute kidney transplant failure following transurethral bladder polyp fulguration..” J Natl Med Assoc 97, no. 3 (March 2005): 414–16.

Scholars@Duke

Tuttle-Newhall, Janet E., Bradley H. Collins, Dev M. Desai, Paul C. Kuo, and Michael A. Heneghan. “The current status of living donor liver transplantation..” Curr Probl Surg 42, no. 3 (March 2005): 144–83. https://doi.org/10.1067/j.cpsurg.2004.12.003.

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