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Bradley Henry Collins, MD

Medical Director, Animal Research
Associate Professor of Surgery
Office: Hanes House, Trent Drive, Durham, NC 27710
Campus Mail: DUMC Box 3512 Med Ctr, Durham, NC 27710

(1) The laboratory's primary focus is the study of the feasibility of transplanting porcine islets into primates as a treatment for type 1 diabetes mellitus. There is a severe shortage of human cadaveric pancreas donors for the 1 to 2 million type 1 diabetics in the United States. The use of human islets would further exacerbate the problem as 2 or 3 pancreases are required per recipient. In collaboration with Dr. Emmanuel Opara, an islet cell physiologist, we have purified islets from porcine pancreases, placed the islets in microcapsules, and transplanted the islets into diabetic baboons without the use of immunosuppression. Our goal is to demonstrated the utility of this system as a pre-clinical model.

(2) Recently, my laboratory has developed an interest in senescence of the liver. The project is a collaborative effort with hepatologist Dr. Don Rockey. We induce cirrhosis in young and old mice with carbon tetrachloride and then extract the intrahepatic lymphocytes. FACS technology is used to identified the lymphocyte populations and then sort them. The cytokine profile is then elucidated. We plan to use gene chip technology to assess the gene expression.

Education and Training

  • Fellow, Surgery, University of Wisconsin at Madison, 1997 - 1999
  • Chief Resident, Surgery, Duke University, 1996 - 1997
  • Senior Assistant Resident, Surgery, Duke University, 1994 - 1996
  • Research Fellow, Surgery, Duke University, 1991 - 1994
  • Junior Assistant Resident, Surgery, Duke University, 1990 - 1991
  • Intern, Surgery, Duke University, 1989 - 1990
  • M.D., Duke University, 1989

Publications

Barbas, A. S., T. E. Sweeney, B. H. Collins, P. C. Kuo, J. E. Tuttle-Newhall, D. L. Sudan, and C. E. Marroquin. “Kidney-pancreas transplantation in the setting of donor ethylene glycol poisoning.” Dialysis and Transplantation 39, no. 5 (May 1, 2010): 216–17. https://doi.org/10.1002/dat.20440.

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Vikraman, Deepak, Bradley H. Collins, Matthew T. Harris, Abigail E. Martin, Todd V. Brennan, Kimberly N. Nicoll, Debra L. Sudan, and Paul C. Kuo. “Single Incision Laparoscopic Donor Nephrectomy Offers No Advantage over Standard Laparoscopic Donor Nephrectomy..” In American Journal of Transplantation, 10:539–539. WILEY-BLACKWELL PUBLISHING, INC, 2010.

Scholars@Duke

Harris, Matt T., B. H. Collins, D. Vikraman, A. E. Martin, T. V. Brennan, D. L. Sudan, and P. C. Kuo. “Sublingual Tacrolimus after High Risk Kidney Transplant.” In American Journal of Transplantation, 10:469–469. WILEY-BLACKWELL PUBLISHING, INC, 2010.

Scholars@Duke

Tracy, Elisabeth T., Kyla M. Bennett, Emeline M. Aviki, Theodore N. Pappas, Bradley H. Collins, Janet E. Tuttle-Newhall, Carlos E. Marroquin, Paul C. Kuo, and John E. Scarborough. “Temporal trends in liver transplant centre volume in the USA..” Hpb (Oxford) 11, no. 5 (August 2009): 414–21. https://doi.org/10.1111/j.1477-2574.2009.00075.x.

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Marroquin, Carlos E., Marion K. Stewart, Barbara O. Burgess, Rebecca D. Nalley, Alastair Smith, Iliana Bouneva, Bradley H. Collins, et al. “Humoral Rejection after Liver Transplantation..” In American Journal of Transplantation, 9:532–33. WILEY-BLACKWELL PUBLISHING, INC, 2009.

Scholars@Duke

Chen, Dongfeng, Deepak Vikraman, Bradley H. Collins, Matthew T. Harris, and Janet E. Tuttle-Newhall. “Intracellular ATP Levels after Liver Transplant Are Associated with Fungal Infections and Increased Risk of Death..” In American Journal of Transplantation, 9:638–39. WILEY-BLACKWELL PUBLISHING, INC, 2009.

Scholars@Duke

Scarborough, John E., Ricardo Pietrobon, Janet E. Tuttle-Newhall, Carlos E. Marroquin, Bradley H. Collins, Dev M. Desai, Paul C. Kuo, and Theodore N. Pappas. “Relationship between provider volume and outcomes for orthotopic liver transplantation..” J Gastrointest Surg 12, no. 9 (September 2008): 1527–33. https://doi.org/10.1007/s11605-008-0589-5.

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Li, B., M. G. Hartwig, J. Z. Appel, E. L. Bush, K. R. Balsara, Z. E. Holzknecht, B. H. Collins, et al. “Chronic aspiration of gastric fluid induces the development of obliterative bronchiolitis in rat lung transplants..” Am J Transplant 8, no. 8 (August 2008): 1614–21. https://doi.org/10.1111/j.1600-6143.2008.02298.x.

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Barbas, A. S., T. E. Downing, K. R. Balsara, H. E. Tan, G. J. Rubinstein, Z. E. Holzknecht, B. H. Collins, W. Parker, R. D. Davis, and S. S. Lin. “Chronic aspiration shifts the immune response from Th1 to Th2 in a murine model of asthma..” Eur J Clin Invest 38, no. 8 (August 2008): 596–602. https://doi.org/10.1111/j.1365-2362.2008.01976.x.

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Scarborough, J. E., J. E. Tuttle-Newhall, R. Pietrobon, C. E. Marroquin, B. H. Collins, D. M. Desai, P. C. Kuo, and T. N. Pappas. “Supply and demand for liver transplant surgery: are we training enough surgeons?.” Hpb (Oxford) 10, no. 1 (2008): 25–29. https://doi.org/10.1080/13651820701883098.

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