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Bradley Henry Collins, MD

Medical Director, Animal Research
Associate Professor of Surgery
Office: Hanes House, Trent Drive, Durham, NC 27710
Campus Mail: DUMC Box 3512 Med Ctr, Durham, NC 27710

(1) The laboratory's primary focus is the study of the feasibility of transplanting porcine islets into primates as a treatment for type 1 diabetes mellitus. There is a severe shortage of human cadaveric pancreas donors for the 1 to 2 million type 1 diabetics in the United States. The use of human islets would further exacerbate the problem as 2 or 3 pancreases are required per recipient. In collaboration with Dr. Emmanuel Opara, an islet cell physiologist, we have purified islets from porcine pancreases, placed the islets in microcapsules, and transplanted the islets into diabetic baboons without the use of immunosuppression. Our goal is to demonstrated the utility of this system as a pre-clinical model.

(2) Recently, my laboratory has developed an interest in senescence of the liver. The project is a collaborative effort with hepatologist Dr. Don Rockey. We induce cirrhosis in young and old mice with carbon tetrachloride and then extract the intrahepatic lymphocytes. FACS technology is used to identified the lymphocyte populations and then sort them. The cytokine profile is then elucidated. We plan to use gene chip technology to assess the gene expression.

Education and Training

  • Fellow, Surgery, University of Wisconsin at Madison, 1997 - 1999
  • Chief Resident, Surgery, Duke University, 1996 - 1997
  • Senior Assistant Resident, Surgery, Duke University, 1994 - 1996
  • Research Fellow, Surgery, Duke University, 1991 - 1994
  • Junior Assistant Resident, Surgery, Duke University, 1990 - 1991
  • Intern, Surgery, Duke University, 1989 - 1990
  • M.D., Duke University, 1989

Publications

Davis, Bradley, Daniele Marin, Lynne M. Hurwitz, James Ronald, Matthew J. Ellis, Kadiyala V. Ravindra, Bradley H. Collins, and Charles Y. Kim. “Application of a Novel CT-Based Iliac Artery Calcification Scoring System for Predicting Renal Transplant Outcomes..” Ajr Am J Roentgenol 206, no. 2 (February 2016): 436–41. https://doi.org/10.2214/AJR.15.14794.

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Martin, B. M., K. P. Samy, M. C. Lowe, P. W. Thompson, J. Cano, A. B. Farris, M. Song, et al. “Dual islet transplantation modeling of the instant blood-mediated inflammatory reaction..” Am J Transplant 15, no. 5 (May 2015): 1241–52. https://doi.org/10.1111/ajt.13098.

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Yurcisin, Basil M., Tara E. Davison, Syreena M. Bibbs, Bradley H. Collins, Jonathan S. Stamler, and James D. Reynolds. “Repletion of S-nitrosohemoglobin improves organ function and physiological status in swine after brain death..” Ann Surg 257, no. 5 (May 2013): 971–77. https://doi.org/10.1097/SLA.0b013e3182822c52.

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Barbas, A. S., A. S. Rege, A. W. Castleberry, J. Gommer, M. J. Ellis, T. V. Brennan, B. H. Collins, et al. “Posterior reversible encephalopathy syndrome independently associated with tacrolimus and sirolimus after multivisceral transplantation..” Am J Transplant 13, no. 3 (March 2013): 808–10. https://doi.org/10.1111/ajt.12061.

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Papalezova, K., C. E. Marroquin, B. H. Collins, J. E. Tuttle-Newhall, and P. C. Kuo. “Liver transplantation.” In Contemporary Surgical Management of Liver, Biliary Tract, and Pancreatic Disease, 173–90, 2013. https://doi.org/10.1142/9789814293068_0012.

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Bush, E. L., K. V. Ravindra, and B. H. Collins. “Surgical techniques: Pancreas transplantation.” In Contemporary Surgical Management of Liver, Biliary Tract, and Pancreatic Disease, 639–46, 2013. https://doi.org/10.1142/9789814293068_0050.

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Ravindra, K. V., A. E. Martin, D. S. Vikraman, T. V. Brennan, B. H. Collins, A. S. Rege, S. T. Hollenbeck, et al. “Use of vascularized posterior rectus sheath allograft in pediatric multivisceral transplantation--report of two cases..” Am J Transplant 12, no. 8 (August 2012): 2242–46. https://doi.org/10.1111/j.1600-6143.2012.04088.x.

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Lunsford, Keri E., Matthew T. Harris, Kimberly N. Nicoll, Bradley H. Collins, Debra L. Sudan, Paul C. Kuo, and Deepak Vikraman. “Single-site laparoscopic living donor nephrectomy offers comparable perioperative outcomes to conventional laparoscopic living donor nephrectomy at a higher cost..” Transplantation, January 27, 2011. https://doi.org/10.1097/TP.0b013e3181fecfe6.

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Alexander, B. D., W. A. Schell, A. M. Siston, C. Y. Rao, W. A. Bower, S. A. Balajee, D. N. Howell, et al. “Fatal Apophysomyces elegans infection transmitted by deceased donor renal allografts..” Am J Transplant 10, no. 9 (September 2010): 2161–67. https://doi.org/10.1111/j.1600-6143.2010.03216.x.

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