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Bradley Henry Collins, MD

Medical Director, Animal Research
Associate Professor of Surgery
Office: Hanes House, Trent Drive, Durham, NC 27710
Campus Mail: DUMC Box 3512 Med Ctr, Durham, NC 27710

(1) The laboratory's primary focus is the study of the feasibility of transplanting porcine islets into primates as a treatment for type 1 diabetes mellitus. There is a severe shortage of human cadaveric pancreas donors for the 1 to 2 million type 1 diabetics in the United States. The use of human islets would further exacerbate the problem as 2 or 3 pancreases are required per recipient. In collaboration with Dr. Emmanuel Opara, an islet cell physiologist, we have purified islets from porcine pancreases, placed the islets in microcapsules, and transplanted the islets into diabetic baboons without the use of immunosuppression. Our goal is to demonstrated the utility of this system as a pre-clinical model.

(2) Recently, my laboratory has developed an interest in senescence of the liver. The project is a collaborative effort with hepatologist Dr. Don Rockey. We induce cirrhosis in young and old mice with carbon tetrachloride and then extract the intrahepatic lymphocytes. FACS technology is used to identified the lymphocyte populations and then sort them. The cytokine profile is then elucidated. We plan to use gene chip technology to assess the gene expression.

Education and Training

  • Fellow, Surgery, University of Wisconsin at Madison, 1997 - 1999
  • Chief Resident, Surgery, Duke University, 1996 - 1997
  • Senior Assistant Resident, Surgery, Duke University, 1994 - 1996
  • Research Fellow, Surgery, Duke University, 1991 - 1994
  • Junior Assistant Resident, Surgery, Duke University, 1990 - 1991
  • Intern, Surgery, Duke University, 1989 - 1990
  • M.D., Duke University, 1989

Publications

Aminsharifi, Alireza, Ross Simon, Thomas J. Polascik, Cary N. Robertson, Debra L. Sudan, Bradley H. Collins, and Judd W. Moul. “Evaluation and Active Treatment versus Active Surveillance of Localized Prostate Cancer in Renal Transplant Patients in the Era of Low and Very Low Risk Prostate Cancer..” J Urol 202, no. 3 (September 2019): 469–74. https://doi.org/10.1097/JU.0000000000000207.

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Mulvihill, Michael S., Kannan P. Samy, Qimeng A. Gao, Robin Schmitz, Robert P. Davis, Brian Ezekian, Francis Leopardi, et al. “Secondary lymphoid tissue and costimulation-blockade resistant rejection: A nonhuman primate renal transplant study..” Am J Transplant 19, no. 8 (August 2019): 2350–57. https://doi.org/10.1111/ajt.15365.

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Kwun, Jean, Marie Matignon, Miriam Manook, Soulef Guendouz, Vincent Audard, David Kheav, Elsa Poullot, et al. “Daratumumab in Sensitized Kidney Transplantation: Potentials and Limitations of Experimental and Clinical Use..” J Am Soc Nephrol 30, no. 7 (July 2019): 1206–19. https://doi.org/10.1681/ASN.2018121254.

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Samy, Kannan P., Qimeng Gao, Robert Patrick Davis, Mingqing Song, Zachary W. Fitch, Michael S. Mulvihill, Andrea L. MacDonald, et al. “The role of human CD46 in early xenoislet engraftment in a dual transplant model..” Xenotransplantation, June 20, 2019. https://doi.org/10.1111/xen.12540.

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Song, M., K. Samy, Q. Gao, R. P. Davis, F. Leopard, Z. Fitch, C. Bennett, G. R. Devi, B. H. Collins, and A. D. Kirk. “CD46 Transgene Modification and Thrombosis in Neonatal Porcine Islet Xenotransplantation..” In American Journal of Transplantation, 19:430–430. WILEY, 2019.

Scholars@Duke

Fitch, Z. W., Q. Gao, R. P. Davis, M. S. Mulvihill, M. Song, F. Leopardi, M. Ribeiro, et al. “Islet Xenotransplantation: A Quest for Clinically Available Immunosuppression Regimens..” In American Journal of Transplantation, 19:473–74. WILEY, 2019.

Scholars@Duke

Samy, K. P., Q. Gao, R. P. Davis, M. Song, Z. W. Fitch, M. S. Mulvihill, A. L. MacDonald, et al. “The role of human CD46 in early xenoislet engraftment in a dual transplant model.” In Xenotransplantation, 2019. https://doi.org/10.1111/xen.12540.

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Samy, K. P., R. P. Davis, Q. Gao, B. M. Martin, M. Song, J. Cano, A. B. Farris, et al. “Early barriers to neonatal porcine islet engraftment in a dual transplant model..” Am J Transplant 18, no. 4 (April 2018): 998–1006. https://doi.org/10.1111/ajt.14601.

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Song, M., M. S. Mulvihill, K. D. Williams, B. H. Collins, and A. D. Kirk. “Fatal SV40-associated pneumonia and nephropathy following renal allotransplantation in rhesus macaque..” J Med Primatol 47, no. 1 (February 2018): 81–84. https://doi.org/10.1111/jmp.12285.

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Samy, K. P., D. J. Anderson, D. J. Lo, M. S. Mulvihill, M. Song, A. B. Farris, B. S. Parker, et al. “Selective Targeting of High-Affinity LFA-1 Does Not Augment Costimulation Blockade in a Nonhuman Primate Renal Transplantation Model..” Am J Transplant 17, no. 5 (May 2017): 1193–1203. https://doi.org/10.1111/ajt.14141.

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