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Bradley Henry Collins, MD

Medical Director, Animal Research
Associate Professor of Surgery
Office: Hanes, Trent Drive, Durham, NC 27710
Campus Mail: DUMC Box 3512 Med Ctr, Durham, NC 27710

(1) The laboratory's primary focus is the study of the feasibility of transplanting porcine islets into primates as a treatment for type 1 diabetes mellitus. There is a severe shortage of human cadaveric pancreas donors for the 1 to 2 million type 1 diabetics in the United States. The use of human islets would further exacerbate the problem as 2 or 3 pancreases are required per recipient. In collaboration with Dr. Emmanuel Opara, an islet cell physiologist, we have purified islets from porcine pancreases, placed the islets in microcapsules, and transplanted the islets into diabetic baboons without the use of immunosuppression. Our goal is to demonstrated the utility of this system as a pre-clinical model.

(2) Recently, my laboratory has developed an interest in senescence of the liver. The project is a collaborative effort with hepatologist Dr. Don Rockey. We induce cirrhosis in young and old mice with carbon tetrachloride and then extract the intrahepatic lymphocytes. FACS technology is used to identified the lymphocyte populations and then sort them. The cytokine profile is then elucidated. We plan to use gene chip technology to assess the gene expression.

Education and Training

  • Fellow, Surgery, University of Wisconsin at Madison, 1997 - 1999
  • Chief Resident, Surgery, Duke University, 1996 - 1997
  • Senior Assistant Resident, Surgery, Duke University, 1994 - 1996
  • Research Fellow, Surgery, Duke University, 1991 - 1994
  • Junior Assistant Resident, Surgery, Duke University, 1990 - 1991
  • Intern, Surgery, Duke University, 1989 - 1990
  • M.D., Duke University, 1989

Publications

Song, M, Mulvihill, MS, Williams, KD, Collins, BH, and Kirk, AD. "Fatal SV40-associated pneumonia and nephropathy following renal allotransplantation in rhesus macaque. (Accepted)" Journal of medical primatology 47, no. 1 (February 2018): 81-84.

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Samy, KP, Davis, RP, Gao, Q, Martin, BM, Song, M, Cano, J, Farris, AB, McDonald, A, Gall, EK, Dove, CR, Leopardi, FV, How, T, Williams, KD, Devi, GR, Collins, BH, and Kirk, AD. "Early barriers to neonatal porcine islet engraftment in a dual transplant model." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (November 25, 2017).

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Samy, KP, Anderson, DJ, Lo, DJ, Mulvihill, MS, Song, M, Farris, AB, Parker, BS, MacDonald, AL, Lu, C, Springer, TA, Kachlany, SC, Reimann, KA, How, T, Leopardi, FV, Franke, KS, Williams, KD, Collins, BH, and Kirk, AD. "Selective Targeting of High-Affinity LFA-1 Does Not Augment Costimulation Blockade in a Nonhuman Primate Renal Transplantation Model." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 17, no. 5 (May 2017): 1193-1203.

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Davis, B, Marin, D, Hurwitz, LM, Ronald, J, Ellis, MJ, Ravindra, KV, Collins, BH, and Kim, CY. "Application of a Novel CT-Based Iliac Artery Calcification Scoring System for Predicting Renal Transplant Outcomes." AJR. American journal of roentgenology 206, no. 2 (February 2016): 436-441.

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Martin, BM, Samy, KP, Lowe, MC, Thompson, PW, Cano, J, Farris, AB, Song, M, Dove, CR, Leopardi, FV, Strobert, EA, Jenkins, JB, Collins, BH, Larsen, CP, and Kirk, AD. "Dual islet transplantation modeling of the instant blood-mediated inflammatory reaction." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 15, no. 5 (May 2015): 1241-1252.

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Reddi, DM, Barbas, AS, Castleberry, AW, Rege, AS, Vikraman, DS, Brennan, TV, Ravindra, KV, Collins, BH, Sudan, DL, Lagoo, AS, and Martin, AE. "Liver transplantation in an adolescent with acute liver failure from acute lymphoblastic leukemia." Pediatric transplantation 18, no. 2 (March 2014): E57-E63.

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Collins, BH, Holzknecht, ZE, Lynn, KA, Sempowski, GD, Smith, CC, Liu, S, Parker, W, and Rockey, DC. "Association of age-dependent liver injury and fibrosis with immune cell populations." Liver Int 33, no. 8 (September 2013): 1175-1186.

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Yurcisin, BM, Davison, TE, Bibbs, SM, Collins, BH, Stamler, JS, and Reynolds, JD. "Repletion of S-nitrosohemoglobin improves organ function and physiological status in swine after brain death." Ann Surg 257, no. 5 (May 2013): 971-977.

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Barbas, AS, Rege, AS, Castleberry, AW, Gommer, J, Ellis, MJ, Brennan, TV, Collins, BH, Martin, AE, Ravindra, KV, Vikraman, DS, and Sudan, DL. "Posterior reversible encephalopathy syndrome independently associated with tacrolimus and sirolimus after multivisceral transplantation." Am J Transplant 13, no. 3 (March 2013): 808-810.

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Papalezova, K, Marroquin, CE, Collins, BH, Tuttle-Newhall, JE, and Kuo, PC. "Liver transplantation." In Contemporary Surgical Management of Liver, Biliary Tract, and Pancreatic Disease, 173-190. January 1, 2013.

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