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Ares D. Pasipoularides, MD, PhD, FACC

Associate Research Professor Emeritus of Surgery
Office: 4554 Hospital South, Durham, NC 27710
Campus Mail: DUMC Box 3851 Med Ctr, Durham, NC 27710

Cardiovascular physiology and pathophysiology; cardiovascular disease; coronary arterial disease; ventricular function; systolic performance and loading; diastolic performance and loading; systolic ejection dynamics; diastolic filling dynamics; arterial dynamics; ventriculo-arterial coupling; myocardial mechanics and properties; cardiac fluid dynamics and computational fluid dynamics; supercomputing simulations of normal and abnormal intracardiac flows; functional imaging of ventricular function.

Prof. Ares Pasipoularides, M.D., Ph.D., F.A.C.C. has made important advances in cardiac research, hemodynamics and genomics by applying methods and principles of chemical engineering, applied mechanics and fluid dynamics to the study of cardiovascular function in health and disease. Throughout his career, he has enjoyed teaching medical, graduate, and undergraduate students and cardiology and cardiac surgery trainees. He received both the M.D., and the Ph.D. (Mathematical Hemodynamics and Chemical Engineering) degrees at the University of Minnesota Medical and Graduate Schools in Minneapolis, respectively, and his postgraduate training in Internal Medicine at Brown University and affiliated hospitals. He is fluent in French, German and Greek, and has reading knowledge of Dutch, Italian, Spanish and Latin.

He has served as an editorial leader for numerous national and international journals and has served as NIH scientific consultant and member of the Study Sections of Cardiac Contractility and Heart Failure, and Surgical Sciences, and Biotechnology.

Before coming to Duke, he was professor of Engineering at Brown University (Section of Fluid Mechanics and Heat Transfer), on the Faculty at Harvard Medical School (the Department of Medicine, the Division of Mathematical Biology, and the New England Regional Primate Research Center), and Associate in Medicine at the Peter Bent Brigham Hospital (Department of Medicine) and the Massachusetts General Hospital (Cardiac Unit); Director of Cardiovascular Research at Brooke Army Medical Center (Cardiology Service, Department of Medicine), Fort Sam Houston, San Antonio, Texas, and professor of Medicine (Cardiovascular Division) at the UTHSC at San Antonio.

At Duke, he has been professor of Medicine (Cardiovascular Division) and of Surgery (Division of Cardiac and Thoracic Surgery) in the School of Medicine, and of Biomedical Engineering in the Duke School of Engineering, and the Director of Cardiac Function at the Duke/NSF Engineering Research Center for Emerging Cardiovascular Technologies.

In all these Institutions, he has taught formal courses in cardiovascular fluid mechanics, clinical hemodynamics, cardiovascular physiology and medicine, mathematical modeling of cardiovascular function in health and disease, computational fluid dynamics of intracardiac flows in health and disease, and artificial organs biotechnology to thousands of medical, science and engineering graduate and undergraduate students, academic cardiologists, anesthesiologists, cardiac imaging specialists, and cardiac surgeons.

His students/fellows at Brown, Harvard, University of Texas and Duke have included trainees at every level of postgraduate medical and graduate engineering, science and applied mathematics education.

He has supervised and participated in the Master’s and PhD Thesis Committees (as Chairman, or member) of numerous graduate biomedical engineering, biomedical science and radiology (cardiac imaging) students at Duke University Graduate School.

He has taught formal academic courses in the Division of Engineering at Brown University, and at the School of Engineering at Duke University, and organized and delivered teaching seminars in the Division of Biology and Medicine at Brown, at the New England Primate Research Center of Harvard Medical School, at the Cardiac Unit of the Massachusetts General Hospital, at the Cardiology Service at Brooke Army Medical Center and the UTHSC at San Antonio (Cardiovascular Division), and at the Cardiac Catheterization Laboratory at Duke School of Medicine and Medical Center.

Education and Training

  • Ph.D., University of Minnesota, Twin Cities, 1972
  • M.D., University of Minnesota, Twin Cities, 1971


Pasipoularides, Ares. “Emulating Leonardo da Vinci (1452-1519): the convergence of science and art in biomedical research and practice.” Cardiovasc Res 115, no. 14 (December 1, 2019): e181–83.

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Pasipoularides, Ares. “Clinical-pathological correlations of BAV and the attendant thoracic aortopathies. Part 1: Pluridisciplinary perspective on their hemodynamics and morphomechanics.” J Mol Cell Cardiol 133 (August 2019): 223–32.

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Pasipoularides, Ares. “Clinical-pathological correlations of BAV and the attendant thoracic aortopathies. Part 2: Pluridisciplinary perspective on their genetic and molecular origins.” J Mol Cell Cardiol 133 (August 2019): 233–46.

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Pasipoularides, Ares. “The new era of whole-exome sequencing in congenital heart disease: brand-new insights into rare pathogenic variants.” J Thorac Dis 10, no. Suppl 17 (June 2018): S1923–29.

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Pasipoularides, Ares. “Challenges and Controversies in Hypertrophic Cardiomyopathy: Clinical, Genomic and Basic Science Perspectives.” Rev Esp Cardiol (Engl Ed) 71, no. 3 (March 2018): 132–38.

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