Our lab focuses on genetic modification of tissues for applications in regenerative medicine, limb loss, and wound healing. We explore the intersection of regenerative biology and gene therapy to both understand and enhance endogenous tissue repair. Our approach, termed genoplastic surgery, seeks to develop a framework and formulary of gene-level interventions to enable the shaping of surgical tissue at the molecular level. Fundamentally, we are a translational plastic surgery lab, aiming to make discoveries at the bench that will materialize into new therapies for patients. This lab is a space of innovation, inspiration, and inclusion. We welcome new ways of thinking about complex problems and new people to drive these ideas forward.

Our primary model system is mouse digit regeneration, one of the few examples of complex tissue regeneration in mammals. We study the role of conserved genes and regulatory sequences in this process, not only to understand underlying mechanisms but also to utilize these elements in gene therapy constructs toward the goal of proximal digit and limb regeneration. Additionally, we are involved in projects exploring tissue regeneration in mammals, including fetal scarless tissue repair and evolutionarily conserved factors in human limb amputations.

Our work is funded by grants from the National Institutes of Health and the Duke Office of Physician-Scientist Development. We are a proud member of the Duke Regeneration Center.