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Wilton Bryan Williams, PhD

Associate Professor in Surgery
Assistant Professor in Immunology
Associate Professor of Medicine
Office: 2 Genome Ct, Durham, NC 27710
Campus Mail: DUMC Box 103010, Durham, NC 27710

Dr. Williams completed a PhD in Biomedical Sciences (Immunology and Microbiology) from the University of Florida and did his postdoctoral work in the laboratory of Dr. Barton Haynes at the Duke Human Vaccine Institute (DHVI).

The key goals of HIV vaccine development are to define the host-virus events during natural HIV infection that lead to the induction of broadly neutralizing antibodies, and to recreate those events with a vaccine. As a junior faculty member in the DHVI, Dr. Williams is further characterizing SHIV non-human primate models for HIV infection, and evaluates B cell responses to HIV-1 vaccination in humans and non-human primates.

Education and Training

  • Ph.D., University of Florida, 2011

Publications

Li, Hui, Wilton Williams, Mattia Bonsignori, Shuyi Wang, Wenge Ding, Fang-Hau Lee, Maho Okumura, et al. “Molecular patterns of SHIV Env-Ab coevolution in rhesus macaques recapitulate HIV-1 Env-Ab co-evolution in humans infected by HIV-1 strains bearing homologous Envs.” In Journal of Medical Primatology, 46:174–75. WILEY, 2017.

Scholars@Duke

Li, Hui, Wilton Williams, Mattia Bonsignori, Shuyi Wang, Wenge Ding, Fang-Hau Lee, Maho Okumura, et al. “Molecular patterns of SHIV Env-Ab coevolution in rhesus macaques recapitulate HIV-1 Env-Ab co-evolution in humans infected by HIV-1 strains bearing homologous envs.” In Journal of Medical Primatology, 46:206–7. WILEY, 2017.

Scholars@Duke

Bonsignori, Mattia, Edward F. Kreider, Daniela Fera, R Ryan Meyerhoff, Todd Bradley, Kevin Wiehe, S Munir Alam, et al. “Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.” Science Translational Medicine 9, no. 381 (March 2017): eaai7514. https://doi.org/10.1126/scitranslmed.aai7514.

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Bonsignori, Mattia, Hua-Xin Liao, Feng Gao, Wilton B. Williams, S Munir Alam, David C. Montefiori, and Barton F. Haynes. “Antibody-virus co-evolution in HIV infection: paths for HIV vaccine development.” Immunol Rev 275, no. 1 (January 2017): 145–60. https://doi.org/10.1111/imr.12509.

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Madani, Navid, Amy M. Princiotto, David Easterhoff, Todd Bradley, Kan Luo, Wilton B. Williams, Hua-Xin Liao, et al. “Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds.” J Virol 90, no. 10 (May 15, 2016): 5031–46. https://doi.org/10.1128/JVI.03211-15.

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Williams, Wilton B., Hua-Xin Liao, M Anthony Moody, Thomas B. Kepler, S Munir Alam, Feng Gao, Kevin Wiehe, et al. “HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies.” Science 349, no. 6249 (August 14, 2015): aab1253. https://doi.org/10.1126/science.aab1253.

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Liao, L. H., A. M. Trama, W. B. Williams, M. A. Moody, N. Vandergrift, G. D. Tomaras, D. J. Marshall, et al. “Role of Intestinal Microbiota in Shaping the B Cell Repertoire in HIV Infection and Env Vaccination.” In Aids Res Hum Retroviruses, 30 Suppl 1:A19, 2014. https://doi.org/10.1089/aid.2014.5023a.abstract.

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Williams, W. B., K. Jones, P. Liu, A. M. Trama, K. Seaton, M. A. Moody, N. Vandergrift, et al. “Antibody Repertoire Induced by the Multiclade (Env A, B, C) HIV-1 DNA Prime, rAd5 Boost VRC Vaccine.” In Aids Research and Human Retroviruses, 29:A9–A9. MARY ANN LIEBERT, INC, 2013.

Scholars@Duke

Wiehe, K., D. Easterhoff, K. Luo, W. Williams, N. Vandergrift, E. Lloyd, C. Stolarchuk, et al. “Phylogenetic Conservation of a Dominant Antibody Light Chain HIV Env V2 Binding Motif in Human and rhesus Macaque Antibodies.” In Aids Research and Human Retroviruses, 29:A168–A168. MARY ANN LIEBERT, INC, 2013.

Scholars@Duke

Yin, Li, Li Liu, Yijun Sun, Wei Hou, Amanda C. Lowe, Brent P. Gardner, Marco Salemi, et al. “High-resolution deep sequencing reveals biodiversity, population structure, and persistence of HIV-1 quasispecies within host ecosystems.” Retrovirology 9 (December 17, 2012): 108. https://doi.org/10.1186/1742-4690-9-108.

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