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Monty Hughes Jr., PhD

Director, Duke University Urinary Dysfunction Laboratory
Assistant Professor in Surgery
Office: 383 MSRB 1, Durham, NC 27710
Campus Mail: DUMC 383 MSRB 1, Durham, NC 27710

 Dr. Hughes received his Ph.D. from the Medical University of South Carolina and was a post doc at both the University of North Carolina at Chapel Hill and NIH. He then joined the faculty of the University of North Carolina at Charlotte where he rose to the rank of Associate Professor (with tenure). Following a brief stint as the director of the biology division of a start-up pharmaceutical company, he joined forces with Dr. Purves at the Medical University of South Carolina to begin this lab focused on benign urinary disorders. Dr. Hughes has been at Duke since 2015. He is currently an Assistant Professor working within the Department of Surgery and Division of Urology. He serves as the Director of the Urinary Dysfunction Laboratory which studies the role of inflammation in disorders such as bladder outlet obstruction and diabetic bladder dysfunction. In association with Dr. J Todd Purves, this lab has been instrumental in demonstrating the central importance of the NLRP3 inflammasome in sensing the biochemical stressors associated with these disorders and translating them into an inflammatory signal. This signal is ultimately responsible for changes in voiding function, denervation and fibrosis.

Education and Training

  • Senior Research Scientist, Surgery / Urology, Duke University School of Medicine, 2015 - 2019
  • Ph.D., Medical University of South Carolina, 1992
  • B.S., Clemson University, 1987

Publications

Hughes, F. M., and J. A. Cidlowski. “Apoptotic DNA degradation: Evidence for novel enzymes.” Cell Death and Differentiation 1, no. 1 (December 1, 1994): 11–17.

Scholars@Duke

HUGHES, F. M., Y. Y. FONG, and W. C. GOROSPE. “INTERLEUKIN-6 STIMULATES APOPTOSIS IN FSH-STIMULATED RAT GRANULOSA-CELLS IN-VITRO - DEVELOPMENT AND UTILIZATION OF AN IN-VITRO MODEL.” Endocrine 2, no. 11 (November 1, 1994): 997–1002.

Scholars@Duke

Johnson, K. M., F. M. Hughes, Y. Y. Fong, R. S. Mathur, H. O. Williamson, and W. C. Gorospe. “Effects of atrial natriuretic peptide on rat ovarian granulosa cell steroidogenesis in vitro.” Am J Reprod Immunol 31, no. 2–3 (March 1994): 163–68. https://doi.org/10.1111/j.1600-0897.1994.tb00861.x.

Full Text

CARONLESLIE, L. A. M., J. W. MONTAGUE, H. YU, F. M. HUGHES, R. A. SCHWARTZMAN, and J. A. CIDLOWSKI. “CORTICOSTEROID INDUCED APOPTOSIS IN THE IMMUNE-SYSTEM - NOVEL MECHANISMS OF REGULATION.” In Journal of Cellular Biochemistry, 140–140. WILEY-LISS, 1993.

Scholars@Duke

MacLeod, R. M., F. M. Hughes, W. C. Gorospe, and B. L. Spangelo. “Synthesis, Release, and Actions of Interleukin 6 in Neuroendocrine Tissues: Methods and Overview.” In Methods in Neurosciences, 17:3–15, 1993. https://doi.org/10.1016/S1043-9471(13)70006-5.

Full Text

Hughes, F. M., and W. C. Gorospe. “Biochemical identification of apoptosis (programmed cell death) in granulosa cells: evidence for a potential mechanism underlying follicular atresia.” Endocrinology 129, no. 5 (November 1991): 2415–22. https://doi.org/10.1210/endo-129-5-2415.

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