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Monty Hughes Jr., PhD

Director, Duke University Urinary Dysfunction Laboratory
Assistant Professor in Surgery
Office: 383 MSRB 1, Durham, NC 27710
Campus Mail: DUMC 383 MSRB 1, Durham, NC 27710

 Dr. Hughes received his Ph.D. from the Medical University of South Carolina and was a post doc at both the University of North Carolina at Chapel Hill and NIH. He then joined the faculty of the University of North Carolina at Charlotte where he rose to the rank of Associate Professor (with tenure). Following a brief stint as the director of the biology division of a start-up pharmaceutical company, he joined forces with Dr. Purves at the Medical University of South Carolina to begin this lab focused on benign urinary disorders. Dr. Hughes has been at Duke since 2015. He is currently an Assistant Professor working within the Department of Surgery and Division of Urology. He serves as the Director of the Urinary Dysfunction Laboratory which studies the role of inflammation in disorders such as bladder outlet obstruction and diabetic bladder dysfunction. In association with Dr. J Todd Purves, this lab has been instrumental in demonstrating the central importance of the NLRP3 inflammasome in sensing the biochemical stressors associated with these disorders and translating them into an inflammatory signal. This signal is ultimately responsible for changes in voiding function, denervation and fibrosis.

Education and Training

  • Senior Research Scientist, Surgery / Urology, Duke University School of Medicine, 2015 - 2019
  • Ph.D., Medical University of South Carolina, 1992
  • B.S., Clemson University, 1987

Publications

Shunmugavel, Anandakumar, Mushfiquddin Khan, Francis M. Hughes, J Todd Purves, Avtar Singh, and Inderjit Singh. “S-Nitrosoglutathione protects the spinal bladder: novel therapeutic approach to post-spinal cord injury bladder remodeling.” Neurourol Urodyn 34, no. 6 (August 2015): 519–26. https://doi.org/10.1002/nau.22619.

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Schneider, Marc P., Francis M. Hughes, Anne K. Engmann, J Todd Purves, Hansjörg Kasper, Marco Tedaldi, Laura S. Spruill, Miriam Gullo, Martin E. Schwab, and Thomas M. Kessler. “A novel urodynamic model for lower urinary tract assessment in awake rats.” Bju Int 115 Suppl 6 (April 2015): 8–15. https://doi.org/10.1111/bju.13039.

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Hughes, Francis M., Nivardo P. Vivar, James G. Kennis, Jeffery D. Pratt-Thomas, Danielle W. Lowe, Brooke E. Shaner, Paul J. Nietert, Laura S. Spruill, and J Todd Purves. “Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation.” Am J Physiol Renal Physiol 306, no. 3 (February 1, 2014): F299–308. https://doi.org/10.1152/ajprenal.00297.2013.

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Hughes, F. M., B. E. Shaner, J. O. Brower, R. J. Woods, and T. A. Dix. “Development of a peptide-derived orally-active kappa-opioid receptor agonist targeting peripheral pain.” Open Medicinal Chemistry Journal 7, no. 1 (November 26, 2013): 16–22. https://doi.org/10.2174/1874104501307010016.

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Hughes, Francis M., Paige McKeithan, Justin Ellett, Kent E. Armeson, and J Todd Purves. “Simvastatin suppresses cyclophosphamide-induced changes in urodynamics and bladder inflammation.” Urology 81, no. 1 (January 2013): 209.e9-209.14. https://doi.org/10.1016/j.urology.2012.08.041.

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Foster, Brent, Snimar Grewal, Ondrea Graves, Francis M. Hughes, and Inna M. Sokolova. “Copper exposure affects hemocyte apoptosis and Perkinsus marinus infection in eastern oysters Crassostrea virginica (Gmelin).” Fish Shellfish Immunol 31, no. 2 (August 2011): 341–49. https://doi.org/10.1016/j.fsi.2011.05.024.

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Hughes, Francis M., Brent Foster, Snimar Grewal, and Inna M. Sokolova. “Apoptosis as a host defense mechanism in Crassostrea virginica and its modulation by Perkinsus marinus.” Fish Shellfish Immunol 29, no. 2 (August 2010): 247–57. https://doi.org/10.1016/j.fsi.2010.03.003.

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Hughes, Francis M., Brooke E. Shaner, Lisa A. May, Lyndsay Zotian, Justin O. Brower, R Jeremy Woods, Michael Cash, et al. “Identification and functional characterization of a stable, centrally active derivative of the neurotensin (8-13) fragment as a potential first-in-class analgesic.” J Med Chem 53, no. 12 (June 24, 2010): 4623–32. https://doi.org/10.1021/jm100092s.

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Roach, Joseph D., Grant T. Aguinaldo, Kaumudi Jonnalagadda, Francis M. Hughes, and Bryan L. Spangelo. “Gamma-aminobutyric acid inhibits synergistic interleukin-6 release but not transcriptional activation in astrocytoma cells.” Neuroimmunomodulation 15, no. 2 (2008): 117–24. https://doi.org/10.1159/000148194.

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Jablonski, Elizabeth M., M Adrian Mattocks, Eugene Sokolov, Leonidas G. Koniaris, Francis M. Hughes, Nelson Fausto, Robert H. Pierce, and Iain H. McKillop. “Decreased aquaporin expression leads to increased resistance to apoptosis in hepatocellular carcinoma.” Cancer Lett 250, no. 1 (May 18, 2007): 36–46. https://doi.org/10.1016/j.canlet.2006.09.013.

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