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Monty Hughes Jr., PhD

Director, Duke University Urinary Dysfunction Laboratory
Assistant Professor in Surgery
Office: 383 MSRB 1, Durham, NC 27710
Campus Mail: DUMC 383 MSRB 1, Durham, NC 27710

 Dr. Hughes received his Ph.D. from the Medical University of South Carolina and was a post doc at both the University of North Carolina at Chapel Hill and NIH. He then joined the faculty of the University of North Carolina at Charlotte where he rose to the rank of Associate Professor (with tenure). Following a brief stint as the director of the biology division of a start-up pharmaceutical company, he joined forces with Dr. Purves at the Medical University of South Carolina to begin this lab focused on benign urinary disorders. Dr. Hughes has been at Duke since 2015. He is currently an Assistant Professor working within the Department of Surgery and Division of Urology. He serves as the Director of the Urinary Dysfunction Laboratory which studies the role of inflammation in disorders such as bladder outlet obstruction and diabetic bladder dysfunction. In association with Dr. J Todd Purves, this lab has been instrumental in demonstrating the central importance of the NLRP3 inflammasome in sensing the biochemical stressors associated with these disorders and translating them into an inflammatory signal. This signal is ultimately responsible for changes in voiding function, denervation and fibrosis.

Education and Training

  • Senior Research Scientist, Surgery / Urology, Duke University School of Medicine, 2015 - 2019
  • Ph.D., Medical University of South Carolina, 1992
  • B.S., Clemson University, 1987

Publications

Hughes, Francis M., Stephanie J. Sexton, Huixia Jin, Vihasa Govada, and J Todd Purves. “Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1β.” Am J Physiol Renal Physiol 313, no. 3 (September 1, 2017): F603–10. https://doi.org/10.1152/ajprenal.00128.2017.

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Purves, J Todd, Laura Spruill, Eric Rovner, Elyse Borisko, Alden McCants, Elizabeth Mugo, Ainsley Wingard, Thomas C. Trusk, Thierry Bacro, and Francis M. Hughes. “A three dimensional nerve map of human bladder trigone.” Neurourol Urodyn 36, no. 4 (April 2017): 1015–19. https://doi.org/10.1002/nau.23049.

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Lütolf, Robin, Huixia Jin, Francis Monty Hughes, and J Todd Purves. “MP23-20 NLRP3/IL-1β MEDIATES DENERVATION DURING BLADDER OUTLET OBSTRUCTION IN RATS.” In Journal of Urology, Vol. 197. Ovid Technologies (Wolters Kluwer Health), 2017. https://doi.org/10.1016/j.juro.2017.02.748.

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Inouye, Brian M., Jillene M. Brooks, Danielle J. Degoski, Francis M. Hughes Jr., J Todd Purves, and Matthew O. Fraser. “MP85-02 ABERRANT BLADDER REFLEXES CAN DRIVE HIND LIMB LOCOMOTOR ACTIVITY FOLLOWING COMPLETE SUPRASACRAL SPINAL CORD INJURY.” In Journal of Urology, Vol. 197. Ovid Technologies (Wolters Kluwer Health), 2017. https://doi.org/10.1016/j.juro.2017.02.2664.

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Inouye, Brian, Francis M. Hughes, Robin Lütolf, Clay Rouse, Wen-Chi Foo, and J Todd Purves. “PD12-06 INFLAMMASOME ACTIVATION EARLY IN THE DEVELOPMENT OF DIABETIC BLADDER DYSFUNCTION.” In Journal of Urology, Vol. 197. Ovid Technologies (Wolters Kluwer Health), 2017. https://doi.org/10.1016/j.juro.2017.02.681.

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Inouye, Brian M., Jillene M. Brooks, Danielle J. Degoski, Francis M. Hughes, J Todd Purves, and Matthew O. Fraser. “ABERRANT BLADDER REFLEXES CAN DRIVE HIND LIMB LOCOMOTOR ACTIVITY FOLLOWING COMPLETE SUPRASACRAL SPINAL CORD INJURY.” In Neurourology and Urodynamics, 36:S20–S20. WILEY-BLACKWELL, 2017.

Scholars@Duke

Hughes, Francis M., Hayden M. Hill, Case M. Wood, Andrew T. Edmondson, Aliya Dumas, Wen-Chi Foo, James M. Oelsen, Goran Rac, and J Todd Purves. “The NLRP3 Inflammasome Mediates Inflammation Produced by Bladder Outlet Obstruction.” J Urol 195, no. 5 (May 2016): 1598–1605. https://doi.org/10.1016/j.juro.2015.12.068.

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Hughes, Francis M., David P. Turner, and J. Todd Purves. “The potential repertoire of the innate immune system in the bladder: expression of pattern recognition receptors in the rat bladder and a rat urothelial cell line (MYP3 cells).” Int Urol Nephrol 47, no. 12 (December 2015): 1953–64. https://doi.org/10.1007/s11255-015-1126-6.

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Sivaraman, S., C. Ambrose, X. Gu, P. Todd, F. M. Hughes, W. Wagner, and J. Nagatomi. “Evaluation of Poly (carbonate-urethane) Urea (pcuu) as a Urinary Bladder Tissue Engineering Scaffold.” In Tissue Engineering Part A, 21:S173–74. MARY ANN LIEBERT, INC, 2015.

Scholars@Duke

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