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Monty Hughes Jr., PhD

Director, Duke University Urinary Dysfunction Laboratory
Assistant Professor in Surgery
Office: 383 MSRB 1, Durham, NC 27710
Campus Mail: DUMC 383 MSRB 1, Durham, NC 27710

 Dr. Hughes received his Ph.D. from the Medical University of South Carolina and was a post doc at both the University of North Carolina at Chapel Hill and NIH. He then joined the faculty of the University of North Carolina at Charlotte where he rose to the rank of Associate Professor (with tenure). Following a brief stint as the director of the biology division of a start-up pharmaceutical company, he joined forces with Dr. Purves at the Medical University of South Carolina to begin this lab focused on benign urinary disorders. Dr. Hughes has been at Duke since 2015. He is currently an Assistant Professor working within the Department of Surgery and Division of Urology. He serves as the Director of the Urinary Dysfunction Laboratory which studies the role of inflammation in disorders such as bladder outlet obstruction and diabetic bladder dysfunction. In association with Dr. J Todd Purves, this lab has been instrumental in demonstrating the central importance of the NLRP3 inflammasome in sensing the biochemical stressors associated with these disorders and translating them into an inflammatory signal. This signal is ultimately responsible for changes in voiding function, denervation and fibrosis.

Education and Training

  • Senior Research Scientist, Surgery / Urology, Duke University School of Medicine, 2015 - 2019
  • Ph.D., Medical University of South Carolina, 1992
  • B.S., Clemson University, 1987

Publications

Hughes, Francis M., Nathan A. Hirshman, Hamza A. Malick, Simon W. White, Huixia Jin, Shelby N. Harper, and J Todd Purves. “A possible mechanism underlying mood disorders associated with LUTS: Chronic bladder outlet obstruction causes NLRP3-dependent inflammation in the hippocampus and depressive behavior in rats.” Neurourol Urodyn 39, no. 6 (August 2020): 1700–1707. https://doi.org/10.1002/nau.24448.

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Wu, Jianxuan, Byron W. Hayes, Cassandra Phoenix, Gustavo Sosa Macias, Yuxuan Miao, Hae Woong Choi, Francis M. Hughes, J. Todd Purves, R. Lee Reinhardt, and Soman N. Abraham. “A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections.” Nat Immunol 21, no. 6 (June 2020): 671–83. https://doi.org/10.1038/s41590-020-0688-3.

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Hirshman, Nathan A., Francis M. Hughes, Huixia Jin, William T. Harrison, Simon W. White, Isabelle Doan, Shelby N. Harper, Patrick D. Leidig, and J Todd Purves. “Cyclophosphamide-induced cystitis results in NLRP3-mediated inflammation in the hippocampus and symptoms of depression in rats.” Am J Physiol Renal Physiol 318, no. 2 (February 1, 2020): F354–62. https://doi.org/10.1152/ajprenal.00408.2019.

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Purves, Todd, Nathan Hirshman, Huixia Jin, Isabelle Doan, Simon White, Shelby Harper, and Francis Hughes. “CYCLOPHOSPHAMIDE-INDUCED CYSTITIS TRIGGERS NLRP3-DEPENDENT NEUROINFLAMMATION IN THE HIPPOCAMPUS AND DEPRESSION IN RATS.” In Journal of Urology, 201:E688–E688. LIPPINCOTT WILLIAMS & WILKINS, 2019.

Scholars@Duke

Sivaraman, Srikanth, Nicholas Amoroso, Xinzhu Gu, J Todd Purves, Francis M. Hughes, William R. Wagner, and Jiro Nagatomi. “Evaluation of Poly (Carbonate-Urethane) Urea (PCUU) Scaffolds for Urinary Bladder Tissue Engineering.” Ann Biomed Eng 47, no. 3 (March 2019): 891–901. https://doi.org/10.1007/s10439-018-02182-0.

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Hughes, Francis M., Nathan A. Hirshman, Brian M. Inouye, Huixia Jin, Eloise W. Stanton, Chloe E. Yun, Leah G. Davis, Jonathan C. Routh, and J Todd Purves. “NLRP3 Promotes Diabetic Bladder Dysfunction and Changes in Symptom-Specific Bladder Innervation.” Diabetes 68, no. 2 (February 2019): 430–40. https://doi.org/10.2337/db18-0845.

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Hughes, Francis M., Stephanie J. Sexton, Patrick D. Ledig, Chloe E. Yun, Huixia Jin, and J Todd Purves. “Bladder decompensation and reduction in nerve density in a rat model of chronic bladder outlet obstruction are attenuated with the NLRP3 inhibitor glyburide.” Am J Physiol Renal Physiol 316, no. 1 (January 1, 2019): F113–20. https://doi.org/10.1152/ajprenal.00400.2018.

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Harper, Shelby N., Patrick D. Leidig, Francis M. Hughes, Huixia Jin, and J Todd Purves. “Calcium Pyrophosphate And Monosodium Urate Activate The NLRP3 Inflammasome Within Bladder Urothelium Via Reactive Oxygen Species And TXNIP.” Res Rep Urol 11 (2019): 319–25. https://doi.org/10.2147/RRU.S225767.

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Dunton, Cody L., J Todd Purves, Francis M. Hughes, Huixia Jin, and Jiro Nagatomi. “Elevated hydrostatic pressure stimulates ATP release which mediates activation of the NLRP3 inflammasome via P2X4 in rat urothelial cells.” Int Urol Nephrol 50, no. 9 (September 2018): 1607–17. https://doi.org/10.1007/s11255-018-1948-0.

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Hirshman, N., F. Hughes, H. Jin, and T. Purves. “BEST IN CATEGORY PRIZE "NEUROUROLOGY" SYMPTOMS OF DIABETIC BLADDER DYSFUNCTION MAY BE EXPLAINED BY SPECIFIC NLRP3-INDUCED CHANGES IN BLADDER AFFERENT NERVES.” In Neurourology and Urodynamics, 37:S164–66. WILEY, 2018.

Scholars@Duke

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