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Li Huang, PhD

Assistant Professor in Surgery
Division: 
Surgical Sciences
Faculty Lab: 
Antiviral Drug Discovery Laboratory
Office: Sorf, Durham, NC 27710
Campus Mail: DUMC Box 2926 Med Ctr, Durham, NC 27710

Education and Training

  • Research Scientist, Surgery, Duke University, 2003 - 2010
  • Instructor, Microbiology, Meharry Medical College, 2002 - 2003
  • Associate Director, Molecular Biology Core Facility, Meharry Medical College, 2001 - 2002
  • Research Associate, Chemistry, Vanderbilt University, 2000 - 2001
  • Postdoctoral Fellow, Microbiology And Immunoloty, Vanderbilt University, 1998 - 2000
  • Ph.D., University of North Carolina - Chapel Hill, 1994

Selected Grants

Publications

Dang, Zhao, Lei Zhu, Lan Xie, Kuo-Hsiung Lee, Faisal Malik, Zhijun Li, Li Huang, and Chin-Ho Chen. “Design and Synthesis of Quinolizidine Derivatives as Influenza Virus and HIV-1 Inhibitors.” Curr Med Chem 28, no. 24 (2021): 4995–5003. https://doi.org/10.2174/0929867328666201229121802.

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Otsuki, Kouharu, Mi Zhang, Asuka Yamamoto, Minami Tsuji, Miyuko Tejima, Zi-Song Bai, Di Zhou, et al. “Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla.” J Nat Prod 83, no. 12 (December 24, 2020): 3584–90. https://doi.org/10.1021/acs.jnatprod.0c00700.

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Otsuki, Kouharu, Wei Li, Kasumi Miura, Yoshihisa Asada, Li Huang, Chin-Ho Chen, Kuo-Hsiung Lee, and Kazuo Koike. “Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora.” J Nat Prod 83, no. 11 (November 25, 2020): 3270–77. https://doi.org/10.1021/acs.jnatprod.0c00540.

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Liu, Qingbo, Yung-Yi Cheng, Wei Li, Li Huang, Yoshihisa Asada, Min-Tsang Hsieh, Susan L. Morris-Natschke, Chin-Ho Chen, Kazuo Koike, and Kuo-Hsiung Lee. “Synthesis and Structure-Activity Relationship Correlations of Gnidimacrin Derivatives as Potent HIV-1 Inhibitors and HIV Latency Reversing Agents.” J Med Chem 62, no. 15 (August 8, 2019): 6958–71. https://doi.org/10.1021/acs.jmedchem.9b00339.

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Wu, Haifeng, Guoxu Ma, Qinwen Yang, Yindi Zhu, Li Huang, Yu Tian, Xiaoming Yang, et al. “Discovery and synthesis of novel beesioside I derivatives with potent anti-HIV activity.” Eur J Med Chem 166 (March 15, 2019): 159–66. https://doi.org/10.1016/j.ejmech.2019.01.020.

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Liu, Qingbo, Wei Li, Li Huang, Yoshihisa Asada, Susan L. Morris-Natschke, Chin-Ho Chen, Kuo-Hsiung Lee, and Kazuo Koike. “Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui.” Eur J Med Chem 156 (August 5, 2018): 618–27. https://doi.org/10.1016/j.ejmech.2018.07.020.

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Huang, Li, Wei-Hong Lai, Lei Zhu, Wei Li, Lei Wei, Kuo-Hsiung Lee, Lan Xie, and Chin-Ho Chen. “Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor.” Acs Med Chem Lett 9, no. 3 (March 8, 2018): 268–73. https://doi.org/10.1021/acsmedchemlett.8b00012.

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Dang, Zhao, Hua Xie, Lei Zhu, Qingye Zhang, Zhijun Li, Li Huang, and Chin-Ho Chen. “Structure Optimization of Aloperine Derivatives as HIV-1 Entry Inhibitors.” Acs Med Chem Lett 8, no. 11 (November 9, 2017): 1199–1203. https://doi.org/10.1021/acsmedchemlett.7b00376.

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Wei, Lei, Hui-Ling Wang, Li Huang, Chin-Ho Chen, Susan L. Morris-Natschke, Kuo-Hsiung Lee, and Lan Xie. “Drug-like property-driven optimization of 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against rilpivirine-resistant mutant virus.” Bioorg Med Chem Lett 27, no. 12 (June 15, 2017): 2788–92. https://doi.org/10.1016/j.bmcl.2017.04.068.

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Thomsen, Alex R. B., Bianca Plouffe, Thomas J. Cahill, Arun K. Shukla, Jeffrey T. Tarrasch, Annie M. Dosey, Alem W. Kahsai, et al. “GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.” Cell 166, no. 4 (August 11, 2016): 907–19. https://doi.org/10.1016/j.cell.2016.07.004.

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