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Karen Christine Baker, MD

Associate Professor of Surgery

I am a Urologist with fellowship training in male fertility and microsurgery. I utilize surgical, medical, and lifestyle interventions in my practice and I work hand-in-hand with our female reproductive specialists to help couples reach their goal of having a baby.  I arrived at Duke after serving 24 years in the Army as a Urologist and male fertility specialist. During my time in the Army I was a Primary or Associate Investigator for over 30 industry sponsored or investigator initiated clinical and basic science trials.
There is much we do not know about infertility in general and male infertility in particular.  My research interests include quantifying the impact of common medical conditions on male fertility and investigating their pathogenic effects on spermatogenesis and sperm function,  delineating the impact of male factor infertility on outcomes of assisted reproductive techniques, and investigating the efficacy of medical therapy for male factor infertility.  I am also interested in the social, psychological and health impacts of infertility.

Education and Training

  • Crile Research Fellow, Surgery/Urology, MetroHealth Medical Center, Cleveland Clinic, 2012 - 2013
  • Male Infertility Fellow, Surgery, MetroHealth Medical Center, Cleveland Clinic, 2011 - 2012
  • Urology Resident, Surgery, Madigan Army Medical Center, 1998 - 2001
  • General Surgery Resident, Surgery, Madigan Army Medical Center, 1997 - 1998
  • General Surgery Intern, Surgery, Madigan Army Medical Center, 1995 - 1996
  • M.D., Uniformed Services University of the Health Sciences F. Edward Hebert School of Medicine, 1995


Baker, Karen, and Raymond A. Costabile. “Demographics, stone characteristic, and treatment of urinary calculi at the 47th Combat Support Hospital during the first 6 months of Operation Iraqi Freedom.” Mil Med 172, no. 5 (May 2007): 498–503.

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Evans, K. C., A. C. Peterson, H. E. Ruiz, and R. A. Costabile. “Use of oral ketoconazole to prevent postoperative erections following penile surgery.” Int J Impot Res 16, no. 4 (August 2004): 346–49.

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Sprenger, Cynthia C., Mary E. Vail, Karen Evans, Jerry Simurdak, and Stephen R. Plymate. “Over-expression of insulin-like growth factor binding protein-related protein-1(IGFBP-rP1/mac25) in the M12 prostate cancer cell line alters tumor growth by a delay in G1 and cyclin A associated apoptosis.” Oncogene 21, no. 1 (January 2002): 140–47.

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