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Jeffrey R. Marks, PhD

Jeffrey Marks, PhD
Professor of Surgery
Professor of Pathology
Office: B216, LSRC, Duke University, Durham, NC 27710
Campus Mail: DUMC Box 3873 Med Ctr, Durham, NC 27710

I have been engaged in basic and applied cancer research for over 28 years beginning with my post-doctoral fellowship under Arnold Levine at Princeton. Since being appointed to the faculty in the Department of Surgery at Duke, my primary interest has been towards understanding breast and ovarian cancer. I am a charter member of the NCI-Early Detection Research Network (EDRN) and have been an integral scientist in the breast and gynecologic collaborative group for 15 years including leading this group for a 5 year period. I am also a major contributor to the Cancer Genome Atlas and have worked in this context for the past 4 years. My research interests are in the molecular etiology of these diseases and understanding how key genetic events contribute to their onset and progression. My work has been very multi-disciplinary incorporating quantitative, population, genetic, and behavioral approaches.  I consider my specialty to be in the area of using human breast and ovarian cancer as the primary and only authentic model system to understand these diseases.  

Education and Training

  • Ph.D., University of California at San Diego, 1985

Selected Grants

Publications

Hwang, E Shelley, Terry Hyslop, Laura H. Hendrix, Stephanie Duong, Isabelle Bedrosian, Elissa Price, Abigail Caudle, et al. “Phase II Single-Arm Study of Preoperative Letrozole for Estrogen Receptor-Positive Postmenopausal Ductal Carcinoma In Situ: CALGB 40903 (Alliance).” J Clin Oncol 38, no. 12 (April 20, 2020): 1284–92. https://doi.org/10.1200/JCO.19.00510.

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Ryser, Marc D., Diego Mallo, Allison Hall, Timothy Hardman, Lorraine M. King, Sergei Tatishchev, Inmaculada C. Sorribes, et al. “Minimal barriers to invasion during human colorectal tumor growth.” Nat Commun 11, no. 1 (March 9, 2020): 1280. https://doi.org/10.1038/s41467-020-14908-7.

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Lin, Chao-Chieh, Nathaniel W. Mabe, Yi-Tzu Lin, Wen-Hsuan Yang, Xiaohu Tang, Lisa Hong, Tianai Sun, et al. “RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence.” Cell Death Differ, January 27, 2020. https://doi.org/10.1038/s41418-020-0499-y.

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Fackler, Mary Jo, Soonweng Cho, Leslie Cope, Edward Gabrielson, Kala Visvanathan, Kathleen Wilsbach, Danielle Meir-Levi, et al. “DNA methylation markers predict recurrence-free interval in triple-negative breast cancer.” Npj Breast Cancer 6 (2020): 3. https://doi.org/10.1038/s41523-020-0145-3.

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Cocce, Kimberly J., Jeff S. Jasper, Taylor K. Desautels, Logan Everett, Suzanne Wardell, Thomas Westerling, Robert Baldi, et al. “The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer.” Cell Rep 29, no. 4 (October 22, 2019): 889-903.e10. https://doi.org/10.1016/j.celrep.2019.09.032.

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Hou, Rui, Maciej A. Mazurowski, Lars J. Grimm, Jeffrey R. Marks, Lorraine M. King, Carlo C. Maley, E Shelley Hwang, and Joseph Y. Lo. “Prediction of Upstaged Ductal Carcinoma in situ Using Forced Labeling and Domain Adaptation.” Ieee Trans Biomed Eng, September 9, 2019. https://doi.org/10.1109/TBME.2019.2940195.

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Narayanan, P. L., S. E. A. Raza, A. Hall, J. R. Marks, L. King, M. Dowsett, B. Gusterson, C. Maley, E. S. Hwang, and Y. Yuan. “Unmasking the Tissue Microecology of Ductal Carcinoma In Situ with Deep Learning.” In Journal of Pathology, 249:S21–S21. WILEY, 2019.

Scholars@Duke

Thorsson, Vésteinn, David L. Gibbs, Scott D. Brown, Denise Wolf, Dante S. Bortone, Tai-Hsien Ou Yang, Eduard Porta-Pardo, et al. “The Immune Landscape of Cancer.” Immunity 51, no. 2 (August 20, 2019): 411–12. https://doi.org/10.1016/j.immuni.2019.08.004.

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Hu, Qingsong, Youqiong Ye, Li-Chuan Chan, Yajuan Li, Ke Liang, Aifu Lin, Sergey D. Egranov, et al. “Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression.” Nat Immunol 20, no. 7 (July 2019): 835–51. https://doi.org/10.1038/s41590-019-0400-7.

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Mazurowski, Maciej A., Ashirbani Saha, Michael R. Harowicz, Elizabeth Hope Cain, Jeffrey R. Marks, and P Kelly Marcom. “Association of distant recurrence-free survival with algorithmically extracted MRI characteristics in breast cancer.” J Magn Reson Imaging 49, no. 7 (June 2019): e231–40. https://doi.org/10.1002/jmri.26648.

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