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Jeffrey R. Marks, PhD

Professor of Surgery
Professor of Pathology
Office: B216, LSRC, Duke University, Durham, NC 27710
Campus Mail: DUMC Box 3873 Med Ctr, Durham, NC 27710

I have been engaged in basic and applied cancer research for over 28 years beginning with my post-doctoral fellowship under Arnold Levine at Princeton. Since being appointed to the faculty in the Department of Surgery at Duke, my primary interest has been towards understanding breast and ovarian cancer. I am a charter member of the NCI-Early Detection Research Network (EDRN) and have been an integral scientist in the breast and gynecologic collaborative group for 15 years including leading this group for a 5 year period. I am also a major contributor to the Cancer Genome Atlas and have worked in this context for the past 4 years. My research interests are in the molecular etiology of these diseases and understanding how key genetic events contribute to their onset and progression. My work has been very multi-disciplinary incorporating quantitative, population, genetic, and behavioral approaches.  I consider my specialty to be in the area of using human breast and ovarian cancer as the primary and only authentic model system to understand these diseases.  

Education and Training

  • Ph.D., University of California - San Diego, 1985

Selected Grants

Publications

Lin, Chao-Chieh, Nathaniel W. Mabe, Yi-Tzu Lin, Wen-Hsuan Yang, Xiaohu Tang, Lisa Hong, Tianai Sun, et al. “RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence.” Cell Death Differ 27, no. 7 (July 2020): 2234–47. https://doi.org/10.1038/s41418-020-0499-y.

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Hou, Rui, Maciej A. Mazurowski, Lars J. Grimm, Jeffrey R. Marks, Lorraine M. King, Carlo C. Maley, Eun-Sil Shelley Hwang, and Joseph Y. Lo. “Prediction of Upstaged Ductal Carcinoma In Situ Using Forced Labeling and Domain Adaptation.” Ieee Trans Biomed Eng 67, no. 6 (June 2020): 1565–72. https://doi.org/10.1109/TBME.2019.2940195.

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Hwang, E Shelley, Terry Hyslop, Laura H. Hendrix, Stephanie Duong, Isabelle Bedrosian, Elissa Price, Abigail Caudle, et al. “Phase II Single-Arm Study of Preoperative Letrozole for Estrogen Receptor-Positive Postmenopausal Ductal Carcinoma In Situ: CALGB 40903 (Alliance).” J Clin Oncol 38, no. 12 (April 20, 2020): 1284–92. https://doi.org/10.1200/JCO.19.00510.

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Rozenblatt-Rosen, Orit, Aviv Regev, Philipp Oberdoerffer, Tal Nawy, Anna Hupalowska, Jennifer E. Rood, Orr Ashenberg, et al. “The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution.” Cell 181, no. 2 (April 16, 2020): 236–49. https://doi.org/10.1016/j.cell.2020.03.053.

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Ryser, Marc D., Diego Mallo, Allison Hall, Timothy Hardman, Lorraine M. King, Sergei Tatishchev, Inmaculada C. Sorribes, et al. “Minimal barriers to invasion during human colorectal tumor growth.” Nat Commun 11, no. 1 (March 9, 2020): 1280. https://doi.org/10.1038/s41467-020-14908-7.

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Rosenberg, Shoshana M., Laura H. Hendrix, Kristin L. Schreiber, Alastair M. Thompson, Isabelle Bedrosian, Kevin S. Hughes, Thomas Lynch, et al. “Abstract P1-21-07: The Patient-reported Outcomes after Routine Treatment of Atypical Lesions (PORTAL) study: Pain, psychosocial wellbeing, and quality of life among women undergoing guideline concordant care for DCIS vs. active surveillance for in situ and atypical lesions.” In Poster Session Abstracts. American Association for Cancer Research, 2020. https://doi.org/10.1158/1538-7445.sabcs19-p1-21-07.

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Angel, Peggi M., Janet Saunders, Heather Jensen-Smith, Evelyn Bruner, Marvella E. Ford, Savanna Berkhiser, Baylye Boxall, et al. “Abstract P2-10-18: Deciphering racial disparities in breast cancer collagen reorganization by targeted extracellular matrix proteomics.” In Poster Session Abstracts. American Association for Cancer Research, 2020. https://doi.org/10.1158/1538-7445.sabcs19-p2-10-18.

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Hou, R., L. J. Grimm, M. A. Mazurowski, J. R. Marks, L. M. King, C. C. Maley, E. S. Hwang, and J. Y. Lo. “A multitask deep learning method in simultaneously predicting occult invasive disease in ductal carcinoma in-situ and segmenting microcalcifications in mammography.” In Progress in Biomedical Optics and Imaging  Proceedings of Spie, Vol. 11314, 2020. https://doi.org/10.1117/12.2549669.

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Fackler, Mary Jo, Soonweng Cho, Leslie Cope, Edward Gabrielson, Kala Visvanathan, Kathleen Wilsbach, Danielle Meir-Levi, et al. “DNA methylation markers predict recurrence-free interval in triple-negative breast cancer.” Npj Breast Cancer 6 (2020): 3. https://doi.org/10.1038/s41523-020-0145-3.

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