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Jeffrey R. Marks, PhD

Vice Chief, Division of Surgical Sciences
Professor in Surgery
Professor of Pathology
Office: B216, LSRC, Duke University, Durham, NC 27710
Campus Mail: DUMC Box 3873 Med Ctr, Durham, NC 27710

I have been engaged in basic and applied cancer research for over 28 years beginning with my post-doctoral fellowship under Arnold Levine at Princeton. Since being appointed to the faculty in the Department of Surgery at Duke, my primary interest has been towards understanding breast and ovarian cancer. I am a charter member of the NCI-Early Detection Research Network (EDRN) and have been an integral scientist in the breast and gynecologic collaborative group for 15 years including leading this group for a 5 year period. I am also a major contributor to the Cancer Genome Atlas and have worked in this context for the past 4 years. My research interests are in the molecular etiology of these diseases and understanding how key genetic events contribute to their onset and progression. My work has been very multi-disciplinary incorporating quantitative, population, genetic, and behavioral approaches.  I consider my specialty to be in the area of using human breast and ovarian cancer as the primary and only authentic model system to understand these diseases.  

Education and Training

  • Ph.D., University of California - San Diego, 1985

Selected Grants

Publications

Hou, Rui, Yifan Peng, Lars J. Grimm, Yinhao Ren, Maciej A. Mazurowski, Jeffrey R. Marks, Lorraine M. King, Carlo C. Maley, E Shelley Hwang, and Joseph Y. Lo. “Anomaly Detection of Calcifications in Mammography Based on 11,000 Negative Cases.” Ieee Trans Biomed Eng 69, no. 5 (May 2022): 1639–50. https://doi.org/10.1109/TBME.2021.3126281.

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Gosling, Sarah, Doriana Calabrese, Jayakrupakar Nallala, Charlene Greenwood, Sarah Pinder, Lorraine King, Jeffrey Marks, et al. “A multi-modal exploration of heterogeneous physico-chemical properties of DCIS breast microcalcifications.” Analyst 147, no. 8 (April 11, 2022): 1641–54. https://doi.org/10.1039/d1an01548f.

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Hou, Rui, Lars J. Grimm, Maciej A. Mazurowski, Jeffrey R. Marks, Lorraine M. King, Carlo C. Maley, Thomas Lynch, et al. “Prediction of Upstaging in Ductal Carcinoma in Situ Based on Mammographic Radiomic Features.” Radiology 303, no. 1 (April 2022): 54–62. https://doi.org/10.1148/radiol.210407.

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Risom, Tyler, David R. Glass, Inna Averbukh, Candace C. Liu, Alex Baranski, Adam Kagel, Erin F. McCaffrey, et al. “Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma.” Cell 185, no. 2 (January 20, 2022): 299-310.e18. https://doi.org/10.1016/j.cell.2021.12.023.

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Narayanan, P. L., S. E. A. Raza, A. H. Hall, J. R. Marks, L. King, R. B. West, L. Hernandez, et al. “Unmasking the immune microecology of ductal carcinoma in situ with deep learning.” In Npj Breast Cancer, Vol. 7, 2021. https://doi.org/10.1038/s41523-020-00205-5.

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Fortunato, Angelo, Diego Mallo, Shawn M. Rupp, Lorraine M. King, Timothy Hardman, Joseph Y. Lo, Allison Hall, Jeffrey R. Marks, E Shelley Hwang, and Carlo C. Maley. “A new method to accurately identify single nucleotide variants using small FFPE breast samples.” Brief Bioinform 22, no. 6 (November 5, 2021). https://doi.org/10.1093/bib/bbab221.

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Ren, Y., J. Lu, Z. Liang, L. J. Grimm, C. Kim, M. Taylor-Cho, S. Yoon, J. R. Marks, and J. Y. Lo. “Retina-Match: Ipsilateral Mammography Lesion Matching in a Single Shot Detection Pipeline.” In Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 12905 LNCS:345–54, 2021. https://doi.org/10.1007/978-3-030-87240-3_33.

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Lin, Chao-Chieh, Nathaniel W. Mabe, Yi-Tzu Lin, Wen-Hsuan Yang, Xiaohu Tang, Lisa Hong, Tianai Sun, et al. “RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence.” Cell Death Differ 27, no. 7 (July 2020): 2234–47. https://doi.org/10.1038/s41418-020-0499-y.

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Hou, Rui, Maciej A. Mazurowski, Lars J. Grimm, Jeffrey R. Marks, Lorraine M. King, Carlo C. Maley, Eun-Sil Shelley Hwang, and Joseph Y. Lo. “Prediction of Upstaged Ductal Carcinoma In Situ Using Forced Labeling and Domain Adaptation.” Ieee Trans Biomed Eng 67, no. 6 (June 2020): 1565–72. https://doi.org/10.1109/TBME.2019.2940195.

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Hwang, E Shelley, Terry Hyslop, Laura H. Hendrix, Stephanie Duong, Isabelle Bedrosian, Elissa Price, Abigail Caudle, et al. “Phase II Single-Arm Study of Preoperative Letrozole for Estrogen Receptor-Positive Postmenopausal Ductal Carcinoma In Situ: CALGB 40903 (Alliance).” J Clin Oncol 38, no. 12 (April 20, 2020): 1284–92. https://doi.org/10.1200/JCO.19.00510.

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