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Jeffrey R. Marks, PhD

Associate Professor of Surgery
Associate Professor of Pathology
Office: B216, LSRC, Duke University, Durham, NC 27710
Campus Mail: DUMC Box 3873 Med Ctr, Durham, NC 27710

I have been engaged in basic and applied cancer research for over 28 years beginning with my post-doctoral fellowship under Arnold Levine at Princeton. Since being appointed to the faculty in the Department of Surgery at Duke, my primary interest has been towards understanding breast and ovarian cancer. I am a charter member of the NCI-Early Detection Research Network (EDRN) and have been an integral scientist in the breast and gynecologic collaborative group for 15 years including leading this group for a 5 year period. I am also a major contributor to the Cancer Genome Atlas and have worked in this context for the past 4 years. My research interests are in the molecular etiology of these diseases and understanding how key genetic events contribute to their onset and progression. My work has been very multi-disciplinary incorporating quantitative, population, genetic, and behavioral approaches.  I consider my specialty to be in the area of using human breast and ovarian cancer as the primary and only authentic model system to understand these diseases.  

Education and Training

  • Ph.D., University of California at San Diego, 1985

Selected Grants

Publications

Wang, S, Liang, K, Hu, Q, Li, P, Song, J, Yang, Y, Yao, J, Mangala, LS, Li, C, Yang, W, Park, PK, Hawke, DH, Zhou, J, Zhou, Y, Xia, W, Hung, M-C, Marks, JR, Gallick, GE, Lopez-Berestein, G, Flores, ER, Sood, AK, Huang, S, Yu, D, Yang, L, and Lin, C. "JAK2-binding long noncoding RNA promotes breast cancer brain metastasis." The Journal of clinical investigation (November 13, 2017).

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Harowicz, MR, Saha, A, Grimm, LJ, Marcom, PK, Marks, JR, Hwang, ES, and Mazurowski, MA. "Can algorithmically assessed MRI features predict which patients with a preoperative diagnosis of ductal carcinoma in situ are upstaged to invasive breast cancer?." Journal of magnetic resonance imaging : JMRI 46, no. 5 (November 2017): 1332-1340.

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Zheng, X, Han, H, Liu, G-P, Ma, Y-X, Pan, R-L, Sang, L-J, Li, R-H, Yang, L-J, Marks, JR, Wang, W, and Lin, A. "LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism." The EMBO journal 36, no. 22 (November 2017): 3325-3335.

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Shi, B, Grimm, LJ, Mazurowski, MA, Baker, JA, Marks, JR, King, LM, Maley, CC, Hwang, ES, and Lo, JY. "Can Occult Invasive Disease in Ductal Carcinoma In Situ Be Predicted Using Computer-extracted Mammographic Features?." Academic radiology 24, no. 9 (September 2017): 1139-1147.

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Chen, P-H, Smith, TJ, Wu, J, Siesser, PF, Bisnett, BJ, Khan, F, Hogue, M, Soderblom, E, Tang, F, Marks, JR, Major, MB, Swarts, BM, Boyce, M, and Chi, J-T. "Glycosylation of KEAP1 links nutrient sensing to redox stress signaling." The EMBO journal 36, no. 15 (August 2017): 2233-2250.

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Lin, A, Hu, Q, Li, C, Xing, Z, Ma, G, Wang, C, Li, J, Ye, Y, Yao, J, Liang, K, Wang, S, Park, PK, Marks, JR, Zhou, Y, Zhou, J, Hung, M-C, Liang, H, Hu, Z, Shen, H, Hawke, DH, Han, L, Zhou, Y, Lin, C, and Yang, L. "The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors." Nature cell biology 19, no. 3 (March 2017): 238-251.

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Fortunato, A, King, L, Mallo, D, Kovacheva, V, Yuan, Y, Boddy, A, Graham, T, Aktipis, A, Mardis, E, Hall, A, Marks, J, Hwang, S, and Maley, C. "Abstract P1-05-30: Genomic and microenvironmental intra-tumor heterogeneity in DCIS." February 15, 2017.

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Ding, Y, Marks, J, King, L, Hall, A, Mardis, E, Rodrigo, A, Maley, C, and Hwang, E-S. "Abstract P1-06-06: Evidence for tumor heterogeneity and clonal evolution during invasive progression of breast cancer." February 15, 2017.

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Harowicz, MR, Robinson, TJ, Dinan, MA, Saha, A, Marks, JR, Marcom, PK, and Mazurowski, MA. "Algorithms for prediction of the Oncotype DX recurrence score using clinicopathologic data: a review and comparison using an independent dataset." Breast cancer research and treatment 162, no. 1 (February 2017): 1-10.

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Harowicz, MR, Marks, JR, Kelly Marcom, P, and Mazurowski, MA. "Can BI-RADS features on mammography be used as a surrogate for expensive genomic testing in breast cancer patients?." January 1, 2017.

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