
I have been engaged in basic and applied cancer research for over 28 years beginning with my post-doctoral fellowship under Arnold Levine at Princeton. Since being appointed to the faculty in the Department of Surgery at Duke, my primary interest has been towards understanding breast and ovarian cancer. I am a charter member of the NCI-Early Detection Research Network (EDRN) and have been an integral scientist in the breast and gynecologic collaborative group for 15 years including leading this group for a 5 year period. I am also a major contributor to the Cancer Genome Atlas and have worked in this context for the past 4 years. My research interests are in the molecular etiology of these diseases and understanding how key genetic events contribute to their onset and progression. My work has been very multi-disciplinary incorporating quantitative, population, genetic, and behavioral approaches. I consider my specialty to be in the area of using human breast and ovarian cancer as the primary and only authentic model system to understand these diseases.
Education and Training
- Ph.D., University of California - San Diego, 1985
In the News
Selected Grants
- sCRA Sample Agreement
- Duke CTSA (TL1) Year 5
- Prevent Ductal Carcinoma in Situ Invasive Overtreatment Now - PRECISION
- Characterizing Molecular Subtypes of Ovarian Cancer in African-American Women
- Molecular and Radiologic Predictors of Invasion in a DCIS Active Surveillance Cohort
- Ovarian Cancer Survival in African-American Women
- Breast Cancer Detection Consortium
- Discovery and validation of putative oncogenic ROS1 alterations in metastatic breast cancer
- Genomic Diversity and the Microenvironment as Drivers of Progression in DCIS
- Molecular and Radiologic Predictors of Invasion in a DCIS Active Surveillance Cohort
- Genetics Training Grant
- Organization and Function of Cellular Structure
- Can contrast dynamics in breast MRI predict genomic intra-tumor heterogeneity
- Molecular and Radiologic Predictors of Invasion in a DCIS Active Surveillance Cohort
- (PQC3) Genomic Diversity and the Microenvironment as Drivers of Metastasis in DCIS
- Fibulin-3 as a Novel Biomarker and Trget in the Breast Tumor Microenvironment
- Molecular and Radiologic Predictors of Invasion in a DCIS Active Surveillance Cohort
- Gene expression programs of lactic acidosis in human cancers
- A Simple System for Early Detection of Breast Cancer
- Atlantic Breast and Gynecologic Clinical Validation Center
- Integrating Population and Basic Science in Cancer Research
- Clinical Oncology Research Career Development Program
- TCGA - Breast Cancer Tissue Acquisition
- Epidemiology of Ovarian Cancer in African-American Women
- Integration of Oncogenic Networks in Cancer Phenotypes
- MAL Promoter Hypermethylation and its Implications in Breast Cancer
- Developing Biomarker-Based Prognostics in Breast Cancer
- Biomarker Studies for Novel Anti-Cancer Agents
- Improving genomic prediction models in breast cancer.
- PPARy: Biomarker for Breast Cancer in Older Women
- Tissue Transglutaminase And Breast Cancer Biology
- Characterization of BRCA2
- Immune Response to Breast Ductal Carcinoma In Situ
- Tissue Transglutaminase And Breast Cancer Biology
- Characterization Of Brca2
- Planning A Program Of Research In Early Breast Cancer
- Spore In Breast Cancer
- Spore In Breast Cancer
- Spore In Breast Cancer
- Surrogate Markers Of Tumor Specific Immunity
- Molecularly-Defined Taa As Human Anti-Tumor Ctl Targets
- Molecularly-Defined Taa As Human Anti-Tumor Ctl Targets
- Molecularly-Defined Taa As Human Anti-Tumor Ctl Targets
- Retinoid Signaling Defects In Breast Cancer
- Retinoid Signalling Defects In Breast Cancer
- P53 In Human Breast Cancer