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Jeffrey R. Marks, PhD

Associate Professor of Surgery
Associate Professor of Pathology
Division: 
Surgical Sciences
Office: B216, LSRC, Duke University, Durham, NC 27710
Campus Mail: DUMC Box 3873 Med Ctr, Durham, NC 27710

I have been engaged in basic and applied cancer research for over 28 years beginning with my post-doctoral fellowship under Arnold Levine at Princeton. Since being appointed to the faculty in the Department of Surgery at Duke, my primary interest has been towards understanding breast and ovarian cancer. I am a charter member of the NCI-Early Detection Research Network (EDRN) and have been an integral scientist in the breast and gynecologic collaborative group for 15 years including leading this group for a 5 year period. I am also a major contributor to the Cancer Genome Atlas and have worked in this context for the past 4 years. My research interests are in the molecular etiology of these diseases and understanding how key genetic events contribute to their onset and progression. My work has been very multi-disciplinary incorporating quantitative, population, genetic, and behavioral approaches.  I consider my specialty to be in the area of using human breast and ovarian cancer as the primary and only authentic model system to understand these diseases.  

Education and Training

  • Ph.D., University of California at San Diego, 1985

Selected Grants

Publications

Hou, Rui, Maciej A. Mazurowski, Lars J. Grimm, Jeffrey R. Marks, Lorraine M. King, Carlo C. Maley, E Shelley Hwang, and Joseph Y. Lo. “Prediction of Upstaged Ductal Carcinoma in situ Using Forced Labeling and Domain Adaptation..” Ieee Trans Biomed Eng, September 9, 2019. https://doi.org/10.1109/TBME.2019.2940195.

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Thorsson, Vésteinn, David L. Gibbs, Scott D. Brown, Denise Wolf, Dante S. Bortone, Tai-Hsien Ou Yang, Eduard Porta-Pardo, et al. “The Immune Landscape of Cancer..” Immunity 51, no. 2 (August 20, 2019): 411–12. https://doi.org/10.1016/j.immuni.2019.08.004.

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Hu, Qingsong, Youqiong Ye, Li-Chuan Chan, Yajuan Li, Ke Liang, Aifu Lin, Sergey D. Egranov, et al. “Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression..” Nat Immunol 20, no. 7 (July 2019): 835–51. https://doi.org/10.1038/s41590-019-0400-7.

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Mazurowski, Maciej A., Ashirbani Saha, Michael R. Harowicz, Elizabeth Hope Cain, Jeffrey R. Marks, and P Kelly Marcom. “Association of distant recurrence-free survival with algorithmically extracted MRI characteristics in breast cancer..” J Magn Reson Imaging 49, no. 7 (June 2019): e231–40. https://doi.org/10.1002/jmri.26648.

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Hu, Qingsong, Chunlai Li, Shouyu Wang, Yajuan Li, Bo Wen, Yanyan Zhang, Ke Liang, et al. “LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition..” Cell Res 29, no. 4 (April 2019): 286–304. https://doi.org/10.1038/s41422-018-0134-3.

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Fortunato, A., D. Mallo, L. King, T. Hardman, A. Hall, J. R. Marks, S. Hwang, and C. C. Maley. “Abstract P3-06-12: Genetic heterogeneity of DCIS is a predictor of invasive cancer.” In Poster Session Abstracts. American Association for Cancer Research, 2019. https://doi.org/10.1158/1538-7445.sabcs18-p3-06-12.

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Hou, R., Y. Ren, L. J. Grimm, M. A. Mazurowski, J. R. Marks, L. King, C. C. Maley, E. Shelley Hwang, and J. Y. Lo. “Malignant microcalcification clusters detection using unsupervised deep autoencoders.” In Progress in Biomedical Optics and Imaging  Proceedings of Spie, Vol. 10950, 2019. https://doi.org/10.1117/12.2512829.

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Cain, Elizabeth Hope, Ashirbani Saha, Michael R. Harowicz, Jeffrey R. Marks, P Kelly Marcom, and Maciej A. Mazurowski. “Multivariate machine learning models for prediction of pathologic response to neoadjuvant therapy in breast cancer using MRI features: a study using an independent validation set..” Breast Cancer Res Treat 173, no. 2 (January 2019): 455–63. https://doi.org/10.1007/s10549-018-4990-9.

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Ren, Y., R. Hou, D. Kong, Y. Geng, L. J. Grimm, J. R. Marks, and J. Y. Lo. “Multiview mammographic mass detection based on a single shot detection system.” In Progress in Biomedical Optics and Imaging  Proceedings of Spie, Vol. 10950, 2019. https://doi.org/10.1117/12.2513136.

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Kong, D., Y. Ren, R. Hou, L. J. Grimm, J. R. Marks, and J. Y. Lo. “Synthesis and texture manipulation of screening mammograms using conditional generative adversarial network.” In Progress in Biomedical Optics and Imaging  Proceedings of Spie, Vol. 10950, 2019. https://doi.org/10.1117/12.2513125.

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