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J Todd Purves, MD, PhD

Associate Professor of Surgery
Division: 
Urology
Faculty Lab: 
Duke University Urinary Dysfunction Laboratory
Program: 
Urology Residency Program

Education and Training

  • Pediatric Urology Fellow, Surgery/Urology, Johns Hopkins University School of Medicine, 2006 - 2008
  • Urology Resident, Surgery/Urology, University of Arizona, College of Medicine, 2002 - 2006
  • General Surgery Resident, Surgery, University of Arizona, College of Medicine, 2000 - 2002
  • M.D., University of Illinois College of Medicine, 2000
  • Ph.D., University of Illinois, Urbana-Champaign, 1998
  • A.B., Cornell University, 1991

Selected Grants

Publications

Dunton, Cody L., J Todd Purves, Francis M. Hughes, and Jiro Nagatomi. “BOO induces fibrosis and EMT in urothelial cells which can be recapitulated in vitro through elevated storage and voiding pressure cycles.” Int Urol Nephrol 53, no. 10 (October 2021): 2007–18. https://doi.org/10.1007/s11255-021-02942-3.

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Johnston, Ashley W., Jonathan C. Routh, J Todd Purves, John S. Wiener, Angela Sinani, and Eda K. Holl. “Immune Expression in Children With Vesicoureteral Reflux: A Pilot Study.” Urology 148 (February 2021): 254–59. https://doi.org/10.1016/j.urology.2020.10.003.

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Dionise, Zachary R., Juan Marcos Gonzalez, Michael L. Garcia-Roig, Andrew J. Kirsch, Charles D. Scales, John S. Wiener, J Todd Purves, and Jonathan C. Routh. “Parental preferences for vesicoureteral reflux treatment: Profile case best-worst scaling.” J Pediatr Urol 17, no. 1 (February 2021): 86.e1-86.e9. https://doi.org/10.1016/j.jpurol.2020.11.020.

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Hobbs, K Tyler, Madison Krischak, Rohit Tejwani, J Todd Purves, John S. Wiener, and Jonathan C. Routh. “The Importance of Early Diagnosis and Management of Pediatric Neurogenic Bladder Dysfunction.” Res Rep Urol 13 (2021): 647–57. https://doi.org/10.2147/RRU.S259307.

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Johnston, Ashley W., John S. Wiener, and J. Todd Purves. “Pediatric Neurogenic Bladder and Bowel Dysfunction: Will My Child Ever Be out of Diapers?” Eur Urol Focus 6, no. 5 (September 15, 2020): 838–67. https://doi.org/10.1016/j.euf.2020.01.003.

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Hughes, Francis M., Nathan A. Hirshman, Hamza A. Malick, Simon W. White, Huixia Jin, Shelby N. Harper, and J Todd Purves. “A possible mechanism underlying mood disorders associated with LUTS: Chronic bladder outlet obstruction causes NLRP3-dependent inflammation in the hippocampus and depressive behavior in rats.” Neurourol Urodyn 39, no. 6 (August 2020): 1700–1707. https://doi.org/10.1002/nau.24448.

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Hughes, F., N. Hirshman, H. Malick, H. Jin, S. Harper, and J. Purves. “A POSSIBLE MECHANISM UNDERLYING MOOD DISORDERS ASSOCIATED WITH LUTS: CHRONIC BLADDER OUTLET OBSTRUCTION CAUSES NLRP3-DEPENDENT INFLAMMATION IN THE HIPPOCAMPUS AND DEPRESSIVE BEHAVIOR IN RATS.” In Neurourology and Urodynamics, 39:S164–65, 2020.

Scholars@Duke

Hughes, F., M. Odom, H. Jin, and J. Purves. “NLRP3 REGULATES THE PROGRESSION FROM BLADDER OVERACTIVITY TO UNDERACTIVITY IN A MOUSE GENETIC MODEL OF TYPE 1 DIABETES (AKITA).” In Neurourology and Urodynamics, 39:S360–61, 2020.

Scholars@Duke

Nose, B., S. Harper, F. Hughes, and J. Purves. “THE ENDOGENOUS ANTI-INFLAMMATORY ANNEXIN A1 AUGMENTS RECOVERY FOLLOWING BLADDER OUTLET DEOBSTRUCTION.” In Neurourology and Urodynamics, 39:S355–56, 2020.

Scholars@Duke

Wu, Jianxuan, Byron W. Hayes, Cassandra Phoenix, Gustavo Sosa Macias, Yuxuan Miao, Hae Woong Choi, Francis M. Hughes, J. Todd Purves, R. Lee Reinhardt, and Soman N. Abraham. “A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections.” Nat Immunol 21, no. 6 (June 2020): 671–83. https://doi.org/10.1038/s41590-020-0688-3.

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