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Gayathri R. Devi, PhD

Associate Director, Research Education
Associate Professor in Surgery
Associate Professor in Pathology
Office: 477 Med.Sci.Res.Bldg. (Msrb1), 2606 DUMC, Durham, NC 27710
Campus Mail: DUMC Box 2606 Med Ctr, Durham, NC 27710

Dr. Devi’s research interests include functional genomics, anti-cancer drug discovery and development, mechanisms of cancer cell signaling, tumor immunity and applications thereof for overcoming therapeutic resistance in cancer.

The lab has established prostate, inflammatory breast cancer and ovarian cellular and tumor models.

Education and Training

  • Ph.D., University of Nebraska College of Medicine, 1998

Publications

Devi, Gayathri R., Doo-Hyun Yang, Ron G. Rosenfeld, and Youngman Oh. “Differential Effects of Insulin-Like Growth Factor (IGF)-Binding Protein-3 and Its Proteolytic Fragments on Ligand Binding, Cell Surface Association, and IGF-I Receptor Signaling* * This research was supported by US Army Grants DAMD17-991-9522 (to G.R.D.) and DAMD17-96-1-6204 and DAMD17-96-1-7204 (to Y.O.H.) and by NIH Grants R01-DK-51513 (to R.G.R.) and CA-58110 (to R.G.R.).” Endocrinology 141, no. 11 (November 1, 2000): 4171–79. https://doi.org/10.1210/endo.141.11.7781.

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Devi, G. R., D. H. Yang, R. G. Rosenfeld, and Y. Oh. “Differential effects of insulin-like growth factor (IGF)-binding protein-3 and its proteolytic fragments on ligand binding, cell surface association, and IGF-I receptor signaling.” Endocrinology 141, no. 11 (November 2000): 4171–79. https://doi.org/10.1210/endo.141.11.7781.

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Rosenfeld, R. G., V. Hwa, L. Wilson, A. Lopez-Bermejo, C. Buckway, C. Burren, W. K. Choi, et al. “The insulin-like growth factor binding protein superfamily: new perspectives.” Pediatrics 104, no. 4 Pt 2 (October 1999): 1018–21.

Scholars@Duke

Devi, G. R., A. T. De Souza, J. C. Byrd, R. L. Jirtle, and R. G. MacDonald. “Altered ligand binding by insulin-like growth factor II/mannose 6-phosphate receptors bearing missense mutations in human cancers.” Cancer Res 59, no. 17 (September 1, 1999): 4314–19.

Scholars@Duke

Byrd, J. C., G. R. Devi, A. T. de Souza, R. L. Jirtle, and R. G. MacDonald. “Disruption of ligand binding to the insulin-like growth factor II/mannose 6-phosphate receptor by cancer-associated missense mutations.” J Biol Chem 274, no. 34 (August 20, 1999): 24408–16. https://doi.org/10.1074/jbc.274.34.24408.

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Devi, G. R., J. C. Byrd, D. H. Slentz, and R. G. MacDonald. “An insulin-like growth factor II (IGF-II) affinity-enhancing domain localized within extracytoplasmic repeat 13 of the IGF-II/mannose 6-phosphate receptor.” Mol Endocrinol 12, no. 11 (November 1998): 1661–72. https://doi.org/10.1210/mend.12.11.0192.

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Garmroudi, F., G. Devi, D. H. Slentz, B. S. Schaffer, and R. G. MacDonald. “Truncated forms of the insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor encompassing the IGF-II binding site: characterization of a point mutation that abolishes IGF-II binding.” Mol Endocrinol 10, no. 6 (June 1996): 642–51. https://doi.org/10.1210/mend.10.6.8776724.

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