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Gayathri R. Devi, PhD

Associate Director, Research Education
Associate Professor in Surgery
Associate Professor in Pathology
Office: 477 Med.Sci.Res.Bldg. (Msrb1), 2606 DUMC, Durham, NC 27710
Campus Mail: DUMC Box 2606 Med Ctr, Durham, NC 27710

Dr. Devi’s research interests include functional genomics, anti-cancer drug discovery and development, mechanisms of cancer cell signaling, tumor immunity and applications thereof for overcoming therapeutic resistance in cancer.

The lab has established prostate, inflammatory breast cancer and ovarian cellular and tumor models.

Education and Training

  • Ph.D., University of Nebraska, College of Medicine, 1998

Publications

London, C. A., D. C. Knapp, Y. J. Ko, S. Balk, M. DeSouza, D. H. Farrell, P. L. Iversen, and G. R. Devi. “In vivo efficacy of phosphorodiamidate morpholino-based antisense oligomers in tumor and angiogenesis models.” In Cancer Gene Therapy, 10:S3–4. NATURE PUBLISHING GROUP, 2003.

Scholars@Duke

Knapp, Derek C., John E. Mata, Muralimohan T. Reddy, Gayathri R. Devi, and Patrick L. Iversen. “Resistance to chemotherapeutic drugs overcome by c-Myc inhibition in a Lewis lung carcinoma murine model.” Anticancer Drugs 14, no. 1 (January 2003): 39–47. https://doi.org/10.1097/00001813-200301000-00006.

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De Sousa, M. A., M. H. Davies, C. A. London, M. R. Powers, G. R. Devi, and D. H. Farrell. “Morpholino antisense oligomer to integrin alpha, inhibits angiogenesis in a mouse model of retinopathy of prematurity.” In Blood, 100:680A-680A. AMER SOC HEMATOLOGY, 2002.

Scholars@Duke

Devi, Gayathri R., Jennifer R. Oldenkamp, Carla A. London, and Patrick L. Iversen. “Inhibition of human chorionic gonadotropin beta-subunit modulates the mitogenic effect of c-myc in human prostate cancer cells.” Prostate 53, no. 3 (November 1, 2002): 200–210. https://doi.org/10.1002/pros.10151.

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De Sousa, M. A., J. D. Bird, C. A. London, P. L. Iversen, G. R. Devi, and D. H. Farrell. “Inhibition of tumor growth using an antisense morpholino oligomer to integrin alpha(v) subunit.” In Arteriosclerosis Thrombosis and Vascular Biology, 22:A15–A15. LIPPINCOTT WILLIAMS & WILKINS, 2002.

Scholars@Duke

Devi, Gayathri R., Cynthia C. Sprenger, Stephen R. Plymate, and Ron G. Rosenfeld. “Insulin-like growth factor binding protein-3 induces early apoptosis in malignant prostate cancer cells and inhibits tumor formation in vivo.” Prostate 51, no. 2 (May 1, 2002): 141–52. https://doi.org/10.1002/pros.10068.

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Devi, Gayathri R. “Prostate cancer: status of current treatments and emerging antisense-based therapies.” Curr Opin Mol Ther 4, no. 2 (April 2002): 138–48.

Scholars@Duke

Devi, G. R., J. R. Oldenkamp, and P. L. Iversen. “Inhibition of human chorionic gonadotropin beta-subunit modulates the mitogenic effect of c-myc in human prostate cancer cells.” In Cancer Gene Therapy, 8:S6–S6. NATURE PUBLISHING GROUP, 2001.

Scholars@Duke

Devi, G. R., D. L. Graham, Y. Oh, and R. G. Rosenfeld. “Effect of IGFBP-3 on IGF- and IGF-analogue-induced insulin-like growth factor-I receptor (IGFIR) signalling.” Growth Horm Igf Res 11, no. 4 (August 2001): 231–39. https://doi.org/10.1054/ghir.2001.0231.

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Lo Pez-Bermejo, A., C. K. Buckway, G. R. Devi, V. Hwa, S. R. Plymate, Y. Oh, and R. G. Rosenfeld. “Characterization of Insulin-Like Growth Factor-Binding Protein-Related Proteins (IGFBP-rPs) 1, 2, and 3 in Human Prostate Epithelial Cells: Potential Roles for IGFBP-rP1 and 2 in Senescence of the Prostatic Epithelium.” Endocrinology 141, no. 11 (November 1, 2000): 4072–80. https://doi.org/10.1210/endo.141.11.7783.

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