Skip to main content

Gayathri R. Devi, PhD

Associate Director, Research Education
Associate Professor in Surgery
Associate Professor in Pathology
Office: 477 Med.Sci.Res.Bldg. (Msrb1), 2606 DUMC, Durham, NC 27710
Campus Mail: DUMC Box 2606 Med Ctr, Durham, NC 27710

Dr. Devi’s research interests include functional genomics, anti-cancer drug discovery and development, mechanisms of cancer cell signaling, tumor immunity and applications thereof for overcoming therapeutic resistance in cancer.

The lab has established prostate, inflammatory breast cancer and ovarian cellular and tumor models.

Education and Training

  • Ph.D., University of Nebraska College of Medicine, 1998

Publications

Allensworth, Jennifer L., Scott J. Sauer, H Kim Lyerly, Michael A. Morse, and Gayathri R. Devi. “Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism.” Breast Cancer Res Treat 137, no. 2 (January 2013): 359–71. https://doi.org/10.1007/s10549-012-2352-6.

Full Text

Devi, G. R., J. L. Allensworth, S. J. Sauer, M. M. Morse, and H. K. Lyerly. “101 Smac Mimetic Induces Apoptosis and Synergizes with TRAIL in Inflammatory Breast Cancer Cells in an IAP-Dependent and TNF-a-Independent Mechanism.” In European Journal of Cancer, 48:32–32. Elsevier BV, 2012. https://doi.org/10.1016/s0959-8049(12)71899-3.

Full Text

Osada, Takuya, Peter Berglund, Michael A. Morse, Bolyn Hubby, Whitney Lewis, Donna Niedzwiecki, Xiao Yi Yang, et al. “Co-delivery of antigen and IL-12 by Venezuelan equine encephalitis virus replicon particles enhances antigen-specific immune responses and antitumor effects.” Cancer Immunol Immunother 61, no. 11 (November 2012): 1941–51. https://doi.org/10.1007/s00262-012-1248-y.

Full Text

Rangwala, Fatima, Kevin P. Williams, Ginger R. Smith, Zainab Thomas, Jennifer L. Allensworth, H Kim Lyerly, Anna Mae Diehl, Michael A. Morse, and Gayathri R. Devi. “Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines.” Bmc Cancer 12 (September 10, 2012): 402. https://doi.org/10.1186/1471-2407-12-402.

Full Text

Allensworth, Jennifer L., Katherine M. Aird, Amy J. Aldrich, Ines Batinic-Haberle, and Gayathri R. Devi. “XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells.” Mol Cancer Ther 11, no. 7 (July 2012): 1518–27. https://doi.org/10.1158/1535-7163.MCT-11-0787.

Full Text

Piacentino, Valentino, Carmelo A. Milano, Michael Bolanos, Jacob Schroder, Emily Messina, Adam S. Cockrell, Edward Jones, et al. “X-linked inhibitor of apoptosis protein-mediated attenuation of apoptosis, using a novel cardiac-enhanced adeno-associated viral vector.” Hum Gene Ther 23, no. 6 (June 2012): 635–46. https://doi.org/10.1089/hum.2011.186.

Full Text

Aird, Katherine M., Jennifer L. Allensworth, Ines Batinic-Haberle, H Kim Lyerly, Mark W. Dewhirst, and Gayathri R. Devi. “ErbB1/2 tyrosine kinase inhibitor mediates oxidative stress-induced apoptosis in inflammatory breast cancer cells.” Breast Cancer Res Treat 132, no. 1 (February 2012): 109–19. https://doi.org/10.1007/s10549-011-1568-1.

Full Text

Morse, M. A., A. Hobeika, D. Serra, K. Aird, M. McKinney, A. Aldrich, T. Clay, et al. “Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function.” Cancer Gene Ther 19, no. 1 (January 2012): 30–37. https://doi.org/10.1038/cgt.2011.63.

Full Text

Ye, Xiaodong, Diane Fels, Artak Tovmasyan, Katherine M. Aird, Casey Dedeugd, Jennifer L. Allensworth, Ivan Kos, et al. “Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate.” Free Radic Res 45, no. 11–12 (November 2011): 1289–1306. https://doi.org/10.3109/10715762.2011.616199.

Full Text

Thomas, Z. I., W. Gibson, J. Z. Sexton, K. M. Aird, S. M. Ingram, A. Aldrich, H. K. Lyerly, G. R. Devi, and K. P. Williams. “Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration.” Br J Cancer 104, no. 10 (May 10, 2011): 1575–86. https://doi.org/10.1038/bjc.2011.133.

Full Text

Pages