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Gayathri R. Devi, PhD

Associate Director, Research Education
Associate Professor in Surgery
Associate Professor in Pathology
Office: 477 Med.Sci.Res.Bldg. (Msrb1), 2606 DUMC, Durham, NC 27710
Campus Mail: DUMC Box 2606 Med Ctr, Durham, NC 27710

Dr. Devi’s research interests include functional genomics, anti-cancer drug discovery and development, mechanisms of cancer cell signaling, tumor immunity and applications thereof for overcoming therapeutic resistance in cancer.

The lab has established prostate, inflammatory breast cancer and ovarian cellular and tumor models.

Education and Training

  • Ph.D., University of Nebraska College of Medicine, 1998

Publications

Oladapo, Helen, Xiaojia Ji, Hassan Shehata, Mike Tarpley, Lhoucine Chdid, David Lamson, Xuhui Bao, Scott Sauer, Gayathri R. Devi, and Kevin P. Williams. “Efficacy of GLI antagonists in triple-negative inflammatory breast cancer 2D and 3D models.” In Cancer Epidemiology Biomarkers & Prevention, 27:131–32. AMER ASSOC CANCER RESEARCH, 2018.

Scholars@Duke

Samy, K. P., R. P. Davis, Q. Gao, B. M. Martin, M. Song, J. Cano, A. B. Farris, et al. “Early barriers to neonatal porcine islet engraftment in a dual transplant model..” Am J Transplant 18, no. 4 (April 2018): 998–1006. https://doi.org/10.1111/ajt.14601.

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Evans, Myron K., Michael C. Brown, Joseph Geradts, Xuhui Bao, Timothy J. Robinson, Mohit Kumar Jolly, Peter B. Vermeulen, et al. “XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype..” Cancer Res 78, no. 7 (April 1, 2018): 1726–38. https://doi.org/10.1158/0008-5472.CAN-17-1667.

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Freel, Stephanie A., Laura J. Fish, Benjamin Mirman, Ranjan Sudan, and Gayathri R. Devi. “Advancement of multidisciplinary education and research in translational sciences: MERITS program development at Duke University..” J Clin Transl Sci 2, no. 1 (February 2018): 57–62. https://doi.org/10.1017/cts.2018.17.

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Gearhart-Serna, Larisa M., Nishad Jayasundara, Moises Tacam, Richard Di Giulio, and Gayathri R. Devi. “Assessing Cancer Risk Associated with Aquatic Polycyclic Aromatic Hydrocarbon Pollution Reveals Dietary Routes of Exposure and Vulnerable Populations..” J Environ Public Health 2018 (2018). https://doi.org/10.1155/2018/5610462.

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Oladapo, Helen O., Michael Tarpley, Scott J. Sauer, Kezia A. Addo, Shalonda M. Ingram, Dillon Strepay, Ben K. Ehe, et al. “Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells..” Cancer Lett 411 (December 28, 2017): 136–49. https://doi.org/10.1016/j.canlet.2017.09.033.

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Arora, Jay, Scott J. Sauer, Michael Tarpley, Peter Vermeulen, Charlotte Rypens, Steven Van Laere, Kevin P. Williams, Gayathri R. Devi, and Mark W. Dewhirst. “Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies.” Oncotarget 8, no. 16 (April 18, 2017): 25848–63.

Scholars@Duke

Arora, Jay, Scott J. Sauer, Michael Tarpley, Peter Vermeulen, Charlotte Rypens, Steven Van Laere, Kevin P. Williams, Gayathri R. Devi, and Mark W. Dewhirst. “Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies..” Oncotarget 8, no. 16 (April 18, 2017): 25848–63. https://doi.org/10.18632/oncotarget.15667.

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Shammas, Ronnie L., Andrew M. Fales, Bridget M. Crawford, Amy J. Wisdom, Gayathri R. Devi, David A. Brown, Tuan Vo-Dinh, and Scott T. Hollenbeck. “Human Adipose-Derived Stem Cells Labeled with Plasmonic Gold Nanostars for Cellular Tracking and Photothermal Cancer Cell Ablation..” Plast Reconstr Surg 139, no. 4 (April 2017): 900e-910e. https://doi.org/10.1097/PRS.0000000000003187.

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Sauer, Scott J., Michael Tarpley, Imran Shah, Akshay V. Save, H Kim Lyerly, Steven R. Patierno, Kevin P. Williams, and Gayathri R. Devi. “Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells..” Carcinogenesis 38, no. 3 (March 1, 2017): 252–60. https://doi.org/10.1093/carcin/bgx003.

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