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Eda K Holl, PhD

Assistant Professor of Surgery
Division: 
Surgical Sciences
Faculty Lab: 
Immunology, Inflammation, and Immunotherapy Laboratory
Office: PO Box 103035, Durham, NC 27710
Campus Mail: DUMC DUMC 103035, Durham, NC 27710

Education and Training

  • Ph.D., University of North Carolina at Chapel Hill, 2010

Selected Grants

Publications

Brown, MC, Holl, EK, Boczkowski, D, Dobrikova, E, Mosaheb, M, Chandramohan, V, Bigner, DD, Gromeier, M, and Nair, SK. "Cancer immunotherapy with recombinant poliovirus induces IFN-dominant activation of dendritic cells and tumor antigen-specific CTLs." Science translational medicine 9, no. 408 (September 2017).

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Holl, EK, Brown, MC, Boczkowski, D, McNamara, MA, George, DJ, Bigner, DD, Gromeier, M, and Nair, SK. "Recombinant oncolytic poliovirus, PVSRIPO, has potent cytotoxic and innate inflammatory effects, mediating therapy in human breast and prostate cancer xenograft models." Oncotarget 7, no. 48 (November 2016): 79828-79841.

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Holl, EK, Shumansky, KL, Borst, LB, Burnette, AD, Sample, CJ, Ramsburg, EA, and Sullenger, BA. "Scavenging nucleic acid debris to combat autoimmunity and infectious disease." Proceedings of the National Academy of Sciences of the United States of America 113, no. 35 (August 15, 2016): 9728-9733.

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Holl, EK, Allen, IC, and Martinez, J. "Holding the Inflammatory System in Check: TLRs and NLRs." Mediators of Inflammation 2016 (2016): 1-2.

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McNamara, MA, Nair, SK, and Holl, EK. "RNA-Based Vaccines in Cancer Immunotherapy." Journal of immunology research 2015 (January 2015): 794528-. (Review)

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Holl, EK, Bond, JE, Selim, MA, Ehanire, T, Sullenger, B, and Levinson, H. "The nucleic acid scavenger polyamidoamine third-generation dendrimer inhibits fibroblast activation and granulation tissue contraction." Plastic and reconstructive surgery 134, no. 3 (September 2014): 420e-433e.

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Holl, EK. "Generation of bone marrow and fetal liver chimeric mice." Methods in molecular biology (Clifton, N.J.) 1032 (January 2013): 315-321.

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Roney, K, Holl, E, and Ting, J. "Immune plexins and semaphorins: old proteins, new immune functions." Protein & Cell 4, no. 1 (January 2013): 17-26.

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Holl, EK, Shumansky, KL, Pitoc, G, Ramsburg, E, and Sullenger, BA. "Nucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responses. (Published online)" PLoS One 8, no. 7 (2013): e69413-.

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Schneider, M, Zimmermann, AG, Roberts, RA, Zhang, L, Swanson, KV, Wen, H, Davis, BK, Allen, IC, Holl, EK, Ye, Z, Rahman, AH, Conti, BJ, Eitas, TK, Koller, BH, and Ting, JP-Y. "The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB." Nature immunology 13, no. 9 (September 2012): 823-831.

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