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Aravind Asokan, PhD

Director of Gene Therapy
Professor in Surgery
Professor of Molecular Genetics and Microbiology
Campus Mail: DUMC 3 Genome Court, Msrb3, 5148, Box 2653, Duke Surgery, Durham, NC 27710

Synthetic Virology & Gene Therapy

Education and Training

  • Ph.D., University of North Carolina at Chapel Hill, 2004

Publications

Shen, Shen, Andrew N. Troupes, Nagesh Pulicherla, and Aravind Asokan. “Multiple roles for sialylated glycans in determining the cardiopulmonary tropism of adeno-associated virus 4..” J Virol 87, no. 24 (December 2013): 13206–13. https://doi.org/10.1128/JVI.02109-13.

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Shen, Shen, Eric D. Horowitz, Andrew N. Troupes, Sarah M. Brown, Nagesh Pulicherla, Richard J. Samulski, Mavis Agbandje-McKenna, and Aravind Asokan. “Engraftment of a galactose receptor footprint onto adeno-associated viral capsids improves transduction efficiency..” J Biol Chem 288, no. 40 (October 4, 2013): 28814–23. https://doi.org/10.1074/jbc.M113.482380.

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Shen, Shen, and Aravind Asokan. “Integrins Play a Pivotal Role in Transvascular Transport and Tissue Uptake of AAV9 In Vivo.” In Molecular Therapy, 21:S30–S30. NATURE PUBLISHING GROUP, 2013.

Scholars@Duke

Murlidharan, Giridhar, Laura Sommerville, Troy Ghashghaei, and Aravind Asokan. “Re-Engineering Capsid-Glycan Interactions Expands the CNS Transduction Profile of AAV Serotype 4.” In Molecular Therapy, 21:S1–S1. NATURE PUBLISHING GROUP, 2013.

Scholars@Duke

Shen, Shen, Andrew Troupes, Nagesh Pulicherla, and Aravind Asokan. “Sialic Acids and Erythrocyte Interactions Are Critical Determinants of Cardiopulmonary Tropism Displayed by AAV Serotype 4.” In Molecular Therapy, 21:S31–S31. NATURE PUBLISHING GROUP, 2013.

Scholars@Duke

Horowitz, Eric D., K Shefaet Rahman, Brian D. Bower, David J. Dismuke, Michael R. Falvo, Jack D. Griffith, Stephen C. Harvey, and Aravind Asokan. “Biophysical and ultrastructural characterization of adeno-associated virus capsid uncoating and genome release..” J Virol 87, no. 6 (March 2013): 2994–3002. https://doi.org/10.1128/JVI.03017-12.

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Shen, Shen, Kelli D. Bryant, Junjiang Sun, Sarah M. Brown, Andrew Troupes, Nagesh Pulicherla, and Aravind Asokan. “Glycan binding avidity determines the systemic fate of adeno-associated virus type 9..” J Virol 86, no. 19 (October 2012): 10408–17. https://doi.org/10.1128/JVI.01155-12.

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Denard, Jerome, Cyriaque Beley, Robert Kotin, Rene Lai-Kuen, Stephane Blot, Herve Leh, Aravind Asokan, et al. “Human galectin 3 binding protein interacts with recombinant adeno-associated virus type 6.” In Human Gene Therapy, 23:A122–A122. MARY ANN LIEBERT INC, 2012.

Scholars@Duke

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