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Aravind Asokan, PhD

Director of Gene Therapy
Professor in Surgery
Professor of Molecular Genetics and Microbiology
Campus Mail: DUMC 3 Genome Court, Msrb3, 5148, Box 2653, Duke Surgery, Durham, NC 27710

Synthetic Virology & Gene Therapy

Education and Training

  • Ph.D., University of North Carolina at Chapel Hill, 2004

Publications

Rao, Lavanya, Blake H. Albright, Travis Corriher, Giridhar Murlidharan, and Aravind Asokan. “42. Differential Transduction Profiles of AAV Vectors in a Mouse Model of Human Glycosylation.” In Molecular Therapy, 23:S18–19. Elsevier BV, 2015. https://doi.org/10.1016/s1525-0016(16)33647-4.

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Rivera, Ruth M Castellanos, Lavanya Rao, Giridhar Murlidharan, Travis Corriher, and Aravind Asokan. “Lymphatic Transport Mediates Systemic Leakage of Peripherally Administered AAV9 Vectors.” In Molecular Therapy, 23:S77–S77. NATURE PUBLISHING GROUP, 2015.

Scholars@Duke

Murlidharan, Giridhar, Travis Corriher, H Troy Ghashghaei, and Aravind Asokan. “Unique glycan signatures regulate adeno-associated virus tropism in the developing brain..” J Virol 89, no. 7 (April 2015): 3976–87. https://doi.org/10.1128/JVI.02951-14.

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Shen, Shen, Garrett E. Berry, Ruth M. Castellanos Rivera, Roland Y. Cheung, Andrew N. Troupes, Sarah M. Brown, Tal Kafri, and Aravind Asokan. “Functional analysis of the putative integrin recognition motif on adeno-associated virus 9..” J Biol Chem 290, no. 3 (January 16, 2015): 1496–1504. https://doi.org/10.1074/jbc.M114.608281.

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Ishikawa, Kiyotake, Kenneth M. Fish, Lisa Tilemann, Kleopatra Rapti, Jaume Aguero, Carlos G. Santos-Gallego, Ahyoung Lee, et al. “Cardiac I-1c overexpression with reengineered AAV improves cardiac function in swine ischemic heart failure..” Mol Ther 22, no. 12 (December 2014): 2038–45. https://doi.org/10.1038/mt.2014.127.

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Pleticha, Josef, Lukas F. Heilmann, Christopher H. Evans, Aravind Asokan, Richard Jude Samulski, and Andreas S. Beutler. “Preclinical toxicity evaluation of AAV for pain: evidence from human AAV studies and from the pharmacology of analgesic drugs..” Mol Pain 10 (September 2, 2014). https://doi.org/10.1186/1744-8069-10-54.

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O’Reilly, Marina, Howard J. Federoff, Yuman Fong, Donald B. Kohn, Amy P. Patterson, Nabil Ahmed, Aravind Asokan, et al. “Gene therapy: charting a future course--summary of a National Institutes of Health Workshop, April 12, 2013..” Hum Gene Ther 25, no. 6 (June 2014): 488–97. https://doi.org/10.1089/hum.2014.045.

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Huang, Lin-Ya, Robert Ng, Edward B. Miller, Robert McKenna, Aravind Asokan, and Mavis Agbandje-McKenna. “Characterizing Essential Receptor Binding Residues for AAV1.” In Molecular Therapy, 22:S2–S2. NATURE PUBLISHING GROUP, 2014.

Scholars@Duke

Tseng, Yu-Shan, Kim Van Vliet, Matias Kaplan, J Kennon Smith, Lavanya Rao, Robert McKenna, Barry J. Byrne, Sergei Zolotukhin, Aravind Asokan, and Mavis Agbandje-McKenna. “Mapping the Antigenic Structure of Adeno-Associated Virus Serotypes 8 and 9.” In Molecular Therapy, 22:S1–S1. NATURE PUBLISHING GROUP, 2014.

Scholars@Duke

Simpson, Elizabeth M., Charles N. de Leeuw, Siu Ling Lam, Andrea J. Korecki, Russell J. Bonaguro, Kaelan Wong, Michelle Zhou, et al. “Regional-CNS MiniPromoters for AAV Are Identified in a High Through-Put Pipeline.” In Molecular Therapy, 22:S112–S112. NATURE PUBLISHING GROUP, 2014.

Scholars@Duke

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