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Aravind Asokan, PhD

Director of Gene Therapy
Professor in Surgery
Professor of Molecular Genetics and Microbiology
Campus Mail: DUMC 3 Genome Court, Msrb3, 5148, Box 2653, Duke Surgery, Durham, NC 27710

Synthetic Virology & Gene Therapy

Education and Training

  • Ph.D., University of North Carolina - Chapel Hill, 2004

Publications

Schreiber, C. A., T. Sakuma, Y. Izumiya, R. K. Bressin, U. Basu, K. Koide, A. Asokan, and Y. Ikeda. “Enhanced AAV vector transduction through genetic and pharmacological inhibition of U2 snRNP components.” In Human Gene Therapy, 26:A3–4. MARY ANN LIEBERT, INC, 2015.

Scholars@Duke

Schreiber, Claire A., Toshie Sakuma, Yoshihiro Izumiya, Sara J. Holditch, Raymond D. Hickey, Robert K. Bressin, Upamanyu Basu, Kazunori Koide, Aravind Asokan, and Yasuhiro Ikeda. “An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses.” Plos Pathog 11, no. 8 (August 2015): e1005082. https://doi.org/10.1371/journal.ppat.1005082.

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Woodard, Kenton, Katharine J. Liang, Thomas Lentz, William Bennett, Aravind Asokan, and Richard Samulski. “Transduction of Mouse Retina by Intravitreal Delivery Using Chimeric Capsids with Altered Glycan Interactions.” In Investigative Ophthalmology & Visual Science, Vol. 56. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2015.

Scholars@Duke

Hemphill, James, Erin K. Borchardt, Kalyn Brown, Aravind Asokan, and Alexander Deiters. “Optical Control of CRISPR/Cas9 Gene Editing.” J Am Chem Soc 137, no. 17 (May 6, 2015): 5642–45. https://doi.org/10.1021/ja512664v.

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Murlidharan, Giridhar, Lavanya Rao, Dan Wang, Travis Corriher, Kyung Seok-Oh, Guangping Gao, R. Jude Samulski, Alice F. Tarantal, and Aravind Asokan. “14. Next Generation AAV Vectors for Limiting Systemic Leakage and Improving Safety Following CNS Administration.” In Molecular Therapy, 23:S6–S6. Elsevier BV, 2015. https://doi.org/10.1016/s1525-0016(16)33618-8.

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Murlidharan, Giridhar, and Aravind Asokan. “265. Polysialic Acid as a Novel Regulator of AAV Tropism in the Developing Brain.” In Molecular Therapy, 23:S106–S106. Elsevier BV, 2015. https://doi.org/10.1016/s1525-0016(16)33874-6.

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Albright, Blake H., Victoria Madigan, Lavanya Rao, John A. Chiorini, Mavis Agbandje-McKenna, and Aravind Asokan. “302. Combinatorial Engineering of a Receptor Footprint on AAV Serotype 4 Yields Novel Vectors.” In Molecular Therapy, 23:S122–S122. Elsevier BV, 2015. https://doi.org/10.1016/s1525-0016(16)33911-9.

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Berry, Garrett E., and Aravind Asokan. “38. Pharmacological Regulation of Vesicular Trafficking as a Strategy to Enhance Recombinant AAV Transduction.” In Molecular Therapy, 23:S17–S17. Elsevier BV, 2015. https://doi.org/10.1016/s1525-0016(16)33643-7.

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Nelson, Christopher E., Ruth M. Castellanos, Fei Ann Ran, Winston Yan, Feng Zhang, Aravind Asokan, and Charles A. Gersbach. “397. Correction of the Dystrophin Gene By the CRISPR/Cas9 System in a Mouse Model of Muscular Dystrophy.” In Molecular Therapy, 23:S157–58. Elsevier BV, 2015. https://doi.org/10.1016/s1525-0016(16)34006-0.

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