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Aravind Asokan, PhD

Director of Gene Therapy
Professor in Surgery
Professor of Molecular Genetics and Microbiology
Campus Mail: DUMC 3 Genome Court, Msrb3, 5148, Box 2653, Duke Surgery, Durham, NC 27710

Synthetic Virology & Gene Therapy

Education and Training

  • Ph.D., University of North Carolina at Chapel Hill, 2004

Publications

Tseng, Yu-Shan, Kim Van Vliet, Lavanya Rao, Robert McKenna, Barry J. Byrne, Aravind Asokan, and Mavis Agbandje-McKenna. “Generation and characterization of anti-Adeno-associated virus serotype 8 (AAV8) and anti-AAV9 monoclonal antibodies..” J Virol Methods 236 (October 2016): 105–10. https://doi.org/10.1016/j.jviromet.2016.07.009.

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Murlidharan, Giridhar, Andrew Crowther, Rebecca A. Reardon, Juan Song, and Aravind Asokan. “Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brain..” Jci Insight 1, no. 14 (September 8, 2016). https://doi.org/10.1172/jci.insight.88034.

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Murlidharan, Giridhar, Kensuke Sakamoto, Lavanya Rao, Travis Corriher, Dan Wang, Guangping Gao, Patrick Sullivan, and Aravind Asokan. “CNS-restricted Transduction and CRISPR/Cas9-mediated Gene Deletion with an Engineered AAV Vector..” Mol Ther Nucleic Acids 5, no. 7 (July 19, 2016). https://doi.org/10.1038/mtna.2016.49.

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Pierson, Elizabeth E., David Z. Keifer, Aravind Asokan, and Martin F. Jarrold. “Resolving Adeno-Associated Viral Particle Diversity With Charge Detection Mass Spectrometry..” Anal Chem 88, no. 13 (July 5, 2016): 6718–25. https://doi.org/10.1021/acs.analchem.6b00883.

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Huang, Lin-Ya, Ami Patel, Robert Ng, Edward Blake Miller, Sujata Halder, Robert McKenna, Aravind Asokan, and Mavis Agbandje-McKenna. “Characterization of the Adeno-Associated Virus 1 and 6 Sialic Acid Binding Site..” J Virol 90, no. 11 (June 1, 2016): 5219–30. https://doi.org/10.1128/JVI.00161-16.

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Leeuw, Charles N. de, Andrea J. Korecki, Garrett E. Berry, Jack W. Hickmott, Siu Ling Lam, Tess C. Lengyell, Russell J. Bonaguro, et al. “rAAV-compatible MiniPromoters for restricted expression in the brain and eye..” Mol Brain 9, no. 1 (May 10, 2016). https://doi.org/10.1186/s13041-016-0232-4.

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Berry, Garrett, Giridhar Murlidharan, and Aravind Asokan. “30. Modulation of Intracellular Calcium Enhances AAV Transduction in the CNS.” In Molecular Therapy, 24:S14–S14. Elsevier BV, 2016. https://doi.org/10.1016/s1525-0016(16)32839-8.

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Nelson, Christopher, Matthew Gemberling, Chady H. Hakim, David G. Ousterout, Pratiksha I. Thakore, Ruth M. Castellanos, Sarina Madhavan, et al. “482. Local and Systemic Gene Editing in a Mouse Model of Duchenne Muscular Dystrophy.” In Molecular Therapy, 24:S191–S191. Elsevier BV, 2016. https://doi.org/10.1016/s1525-0016(16)33291-9.

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Robinson-Hamm, Jacqueline N., Christopher E. Nelson, Ruth M Castellanos Rivera, Annemieke Aartsma-Rus, Aravind Asokan, and Charles A. Gersbach. “504. Restoration of Dystrophin Expression by Gene Editing with S. aureus Cas9 in Models of Duchenne Muscular Dystrophy.” In Molecular Therapy, 24:S201–S201. Elsevier BV, 2016. https://doi.org/10.1016/s1525-0016(16)33313-5.

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