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Aravind Asokan, PhD

Director of Gene Therapy
Professor in Surgery
Professor of Molecular Genetics and Microbiology
Campus Mail: DUMC 3 Genome Court, Msrb3, 5148, Box 2653, Duke Surgery, Durham, NC 27710

Synthetic Virology & Gene Therapy

Education and Training

  • Ph.D., University of North Carolina at Chapel Hill, 2004

Publications

Rivera, Ruth M Castellanos, Austin D. Sun, Marco Fanous, and Aravind Asokan. “Disruption of Water Homeostasis Affects AAV Transport Across the Blood-Brain Barrier.” In Molecular Therapy, 25:109–109. CELL PRESS, 2017.

Scholars@Duke

Robinson-Hamm, Jacqueline N., Christopher E. Nelson, Matthew Gemberling, Ruth M Castellanos Rivera, Annemieke Aartsma-Rus, Aravind Asokan, and Charles A. Gersbach. “Dystrophin Restoration in a Humanized Mouse Model of Duchenne Muscular Dystrophy by Gene Editing with S. aureus Cas9.” In Molecular Therapy, 25:17–17. CELL PRESS, 2017.

Scholars@Duke

Moller-Tank, Sven, Ruth M. Castellanos, Daniel Oh, Longping V. Tse, Miranda L. Scalabrino, and Aravind Asokan. “Expanding the CNS Transduction Profile of AAV4 by Structure-Guided Evolution.” In Molecular Therapy, 25:247–247. CELL PRESS, 2017.

Scholars@Duke

Borchardt, Erin K., Rita M. Meganck, Heather A. Vincent, Christopher B. Ball, Silvia B. V. Ramos, Nathaniel J. Moorman, William F. Marzluff, and Aravind Asokan. “Inducing circular RNA formation using the CRISPR endoribonuclease Csy4..” Rna 23, no. 5 (May 2017): 619–27. https://doi.org/10.1261/rna.056838.116.

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Nelson, Christopher, Matthew Gemberling, Sarina Madhavan, Ruth M Castellanos Rivera, Aravind Asokan, and Charles A. Gersbach. “Long-Term Characterization of In Vivo Genome Editing in a Mouse Model of Duchenne Muscular Dystrophy.” In Molecular Therapy, 25:100–101. CELL PRESS, 2017.

Scholars@Duke

Smith, J Kennon S., Yu-Shan Tseng, Daniel Noe, Mathias Kaplan, Lavanya Rao, Robert McKenna, Sergei Zolotukhin, et al. “Structural Mapping of AAV9 Antigenic Sites and the Engineering of Immune Escape Variants.” In Molecular Therapy, 25:337–337. CELL PRESS, 2017.

Scholars@Duke

Tse, Longping V., Kelli A. Klinc, Victoria J. Madigan, Ruth M Castellanos Rivera, Lindsey F. Wells, L Patrick Havlik, J Kennon Smith, Mavis Agbandje-McKenna, and Aravind Asokan. “Structure-Guided Iterative Evolution of Antigenically Advanced AAV Variants for Therapeutic Gene Transfer.” In Molecular Therapy, 25:232–232. CELL PRESS, 2017.

Scholars@Duke

Tarantal, Alice F., C Chang I. Lee, Michele L. Martinez, Aravind Asokan, and R Jude Samulski. “Systemic and Persistent Muscle Gene Expression in Rhesus Monkeys with a Liver De-Targeted Adeno-Associated Virus Vector..” Hum Gene Ther 28, no. 5 (May 2017): 385–91. https://doi.org/10.1089/hum.2016.130.

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Zeng, Cheng, Sven Moller-Tank, Aravind Asokan, and Bogdan Dragnea. “Probing the Link among Genomic Cargo, Contact Mechanics, and Nanoindentation in Recombinant Adeno-Associated Virus 2..” J Phys Chem B 121, no. 8 (March 2, 2017): 1843–53. https://doi.org/10.1021/acs.jpcb.6b10131.

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