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Aravind Asokan, PhD

Director of Gene Therapy
Professor in Surgery
Professor of Molecular Genetics and Microbiology
Campus Mail: DUMC 3 Genome Court, Msrb3, 5148, Box 2653, Duke Surgery, Durham, NC 27710

Synthetic Virology & Gene Therapy

Education and Training

  • Ph.D., University of North Carolina - Chapel Hill, 2004

Publications

Nelson, Christopher, Yaoying Wu, Matthew Gemberling, Matthew Oliver, Joel D. Bohning, Jacqueline N. Robinson-Hamm, Karen Bulaklak, et al. “Long-Term Evaluation of AAV-CRISPR Genome Editing for Duchenne Muscular Dystrophy.” In Molecular Therapy, 27:46–47. CELL PRESS, 2019.

Scholars@Duke

Madigan, Victoria, Tyne O. Tyson, and Aravind Asokan. “Mass Spectrometric Identification of Host Factors that Restrict AAV Vector Genome Transcription.” In Molecular Therapy, 27:425–425. CELL PRESS, 2019.

Scholars@Duke

Castle, Michael J., Yuhsiang Cheng, Aravind Asokan, and Mark H. Tuszynski. “Physical Positioning Dramatically Improves Brain Transduction after Intrathecal Infusion of AAV9.” In Molecular Therapy, 27:97–98. CELL PRESS, 2019.

Scholars@Duke

Nelson, Christopher E., Yaoying Wu, Matthew P. Gemberling, Matthew L. Oliver, Matthew A. Waller, Joel D. Bohning, Jacqueline N. Robinson-Hamm, et al. “Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy.” Nat Med 25, no. 3 (March 2019): 427–32. https://doi.org/10.1038/s41591-019-0344-3.

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Mestre, Humberto, Lauren M. Hablitz, Anna Lr Xavier, Weixi Feng, Wenyan Zou, Tinglin Pu, Hiromu Monai, et al. “Aquaporin-4-dependent glymphatic solute transport in the rodent brain.” Elife 7 (December 18, 2018). https://doi.org/10.7554/eLife.40070.

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Meganck, Rita M., Erin K. Borchardt, Ruth M. Castellanos Rivera, Miranda L. Scalabrino, Jeremy E. Wilusz, William F. Marzluff, and Aravind Asokan. “Tissue-Dependent Expression and Translation of Circular RNAs with Recombinant AAV Vectors In Vivo.” Mol Ther Nucleic Acids 13 (December 7, 2018): 89–98. https://doi.org/10.1016/j.omtn.2018.08.008.

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Castle, Michael J., Yuhsiang Cheng, Aravind Asokan, and Mark H. Tuszynski. “Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion.” Sci Adv 4, no. 11 (November 2018): eaau9859. https://doi.org/10.1126/sciadv.aau9859.

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Burwitz, Benjamin, Jochen Wettengel, Martin Muck-Hausl, Katherine Hammond, Marc Ringelhan, Chunkyu Ko, Jason Reed, et al. “A new HIV/HBV co-infection model: hepatocytic expression of human sodium taurocholate cotransporting polypeptide (NTCP) Enables Hepatitis B Virus Infection of Macaques.” In Journal of Medical Primatology, 47:324–324. WILEY, 2018.

Scholars@Duke

Tse, Longping V., Sven Moller-Tank, Rita M. Meganck, and Aravind Asokan. “Mapping and Engineering Functional Domains of the Assembly-Activating Protein of Adeno-associated Viruses.” J Virol 92, no. 14 (July 15, 2018). https://doi.org/10.1128/JVI.00393-18.

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Albright, Blake H., Claire Storey, Garth Devlin, Mavis Agbandje-McKenna, and Aravind Asokan. “Capsid-Glycan Receptor Interactions Influence AAV Transport across the Blood-Brain Barrier.” In Molecular Therapy, 26:29–29. CELL PRESS, 2018.

Scholars@Duke

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