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Aravind Asokan, PhD

Director of Gene Therapy
Professor in Surgery
Professor of Molecular Genetics and Microbiology
Campus Mail: DUMC 3 Genome Court, Msrb3, 5148, Box 2653, Duke Surgery, Durham, NC 27710

Synthetic Virology & Gene Therapy

Education and Training

  • Ph.D., University of North Carolina at Chapel Hill, 2004

Publications

Nelson, Christopher, Matthew Gemberling, Matthew L. Oliver, Chady H. Hakim, Ruth M Castellanos Rivera, Aravind Asokan, Dongsheng Duan, and Charles A. Gersbach. “Long-Term Evaluation of Genome Editing Outcomes for Duchenne Muscular Dystrophy.” In Molecular Therapy, 26:431–32. CELL PRESS, 2018.

Scholars@Duke

Tse, Longping V., Sven Moller-Tank, Rita M. Meganck, Mavis Agbandje-McKenna, and Aravind Asokan. “Mapping and Engineering Functional Domains of the Assembly Activating Protein of Adeno-Associated Viruses.” In Molecular Therapy, 26:27–28. CELL PRESS, 2018.

Scholars@Duke

Madigan, Victoria J., Julianne Yuziuk, Longping V. Tse, Anna Chiarella, Tyne Tyson, Nate Hathaway, and Aravind Asokan. “RNF121 is a Key Transcriptional Regulator of AAV Genome Expression.” In Molecular Therapy, 26:27–27. CELL PRESS, 2018.

Scholars@Duke

Meganck, Rita M., Erin K. Bochardt, Ruth M. Castellanos, Miranda L. Scalabrino, Jeremy Wilusz, William F. Marzluff, and Aravind Asokan. “Systemic Expression of Translatable Circular Rnas Using Recombinant AAV Vectors.” In Molecular Therapy, 26:273–273. CELL PRESS, 2018.

Scholars@Duke

Crowther, Andrew J., Szu-Aun Lim, Brent Asrican, Blake H. Albright, Josh Wooten, Chia-Yu Yeh, Hechen Bao, et al. “An Adeno-Associated Virus-Based Toolkit for Preferential Targeting and Manipulating Quiescent Neural Stem Cells in the Adult Hippocampus..” Stem Cell Reports 10, no. 3 (March 13, 2018): 1146–59. https://doi.org/10.1016/j.stemcr.2018.01.018.

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Albright, Blake H., Claire M. Storey, Giridhar Murlidharan, Ruth M. Castellanos Rivera, Garrett E. Berry, Victoria J. Madigan, and Aravind Asokan. “Mapping the Structural Determinants Required for AAVrh.10 Transport across the Blood-Brain Barrier..” Mol Ther 26, no. 2 (February 7, 2018): 510–23. https://doi.org/10.1016/j.ymthe.2017.10.017.

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Burwitz, Benjamin J., Jochen M. Wettengel, Martin A. Mück-Häusl, Marc Ringelhan, Chunkyu Ko, Marvin M. Festag, Katherine B. Hammond, et al. “Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques..” Nat Commun 8, no. 1 (December 15, 2017). https://doi.org/10.1038/s41467-017-01953-y.

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Guo, Jiami, James M. Otis, Holden Higginbotham, Chase Monckton, JrGang Cheng, Aravind Asokan, Kirk Mykytyn, Tamara Caspary, Garret D. Stuber, and E. S. Anton. “Primary Cilia Signaling Shapes the Development of Interneuronal Connectivity..” Dev Cell 42, no. 3 (August 7, 2017): 286-300.e4. https://doi.org/10.1016/j.devcel.2017.07.010.

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Tse, Longping Victor, Kelli A. Klinc, Victoria J. Madigan, Ruth M. Castellanos Rivera, Lindsey F. Wells, L Patrick Havlik, J Kennon Smith, Mavis Agbandje-McKenna, and Aravind Asokan. “Structure-guided evolution of antigenically distinct adeno-associated virus variants for immune evasion..” Proc Natl Acad Sci U S A 114, no. 24 (June 13, 2017): E4812–21. https://doi.org/10.1073/pnas.1704766114.

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Albright, Blake, Claire Storey, Giridhar Murlidharan, Ruth Castellanos Rivera, and Aravind Asokan. “Discovery of a Neurotropic Footprint That Enables AAV Transport Across the Blood-Brain Barrier.” In Molecular Therapy, 25:230–31. CELL PRESS, 2017.

Scholars@Duke

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