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Aravind Asokan, PhD

Director of Gene Therapy
Professor in Surgery
Professor of Molecular Genetics and Microbiology
Campus Mail: DUMC 3 Genome Court, Msrb3, 5148, Box 2653, Duke Surgery, Durham, NC 27710

Synthetic Virology & Gene Therapy

Education and Training

  • Ph.D., University of North Carolina - Chapel Hill, 2004

Publications

Asokan, Aravind, Julia C. Conway, Jana L. Phillips, Chengwen Li, Julia Hegge, Rebecca Sinnott, Swati Yadav, et al. “Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle.” Nat Biotechnol 28, no. 1 (January 2010): 79–82. https://doi.org/10.1038/nbt.1599.

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Li, Chengwen, Matt Hirsch, Nina DiPrimio, Aravind Asokan, Kevin Goudy, Roland Tisch, and R Jude Samulski. “Cytotoxic-T-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo.” J Virol 83, no. 13 (July 2009): 6817–24. https://doi.org/10.1128/JVI.00278-09.

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Li, Chengwen, Kevin Goudy, Matt Hirsch, Aravind Asokan, Yun Fan, Jeff Alexander, Junjiang Sun, et al. “Cellular immune response to cryptic epitopes during therapeutic gene transfer.” Proc Natl Acad Sci U S A 106, no. 26 (June 30, 2009): 10770–74. https://doi.org/10.1073/pnas.0902269106.

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Xiao, Ping-Jie, Jarrod S. Johnson, Aaron Neumann, Xinghua Zeng, Aravind Asokan, and Richard J. Samulski. “Imaging Trafficking Dynamics of Ultra-Pure Single Adeno-Associated Virus in Live Cells.” In Molecular Therapy, 17:S38–S38. NATURE PUBLISHING GROUP, 2009.

Scholars@Duke

Li, C., M. Hirsch, P. Carter, A. Asokan, X. Zhou, Z. Wu, and R. J. Samulski. “A small regulatory element from chromosome 19 enhances liver-specific gene expression.” Gene Ther 16, no. 1 (January 2009): 43–51. https://doi.org/10.1038/gt.2008.134.

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Asokan, A., J. S. Johnson, C. Li, and R. J. Samulski. “Bioluminescent virion shells: new tools for quantitation of AAV vector dynamics in cells and live animals.” Gene Ther 15, no. 24 (December 2008): 1618–22. https://doi.org/10.1038/gt.2008.127.

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Li, Wuping, Aravind Asokan, Zhijian Wu, Terry Van Dyke, Nina DiPrimio, Jarrod S. Johnson, Lakshmanan Govindaswamy, et al. “Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles.” Mol Ther 16, no. 7 (July 2008): 1252–60. https://doi.org/10.1038/mt.2008.100.

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DiPrimio, Nina, Aravind Asokan, Lakshmanan Govindasamy, Mavis Agbandje-McKenna, and R Jude Samulski. “Surface loop dynamics in adeno-associated virus capsid assembly.” J Virol 82, no. 11 (June 2008): 5178–89. https://doi.org/10.1128/JVI.02721-07.

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Li, Chengwen, Matthew Hirsch, Aravind Asokan, Brian Zeithaml, Hong Ma, Tal Kafri, and R Jude Samulski. “Adeno-associated virus type 2 (AAV2) capsid-specific cytotoxic T lymphocytes eliminate only vector-transduced cells coexpressing the AAV2 capsid in vivo.” J Virol 81, no. 14 (July 2007): 7540–47. https://doi.org/10.1128/JVI.00529-07.

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Choi, Vivian W., Aravind Asokan, Rebecca A. Haberman, and Richard Jude Samulski. “Production of recombinant adeno-associated viral vectors for in vitro and in vivo use.” Curr Protoc Mol Biol Chapter 16 (April 2007): Unit-16.25. https://doi.org/10.1002/0471142727.mb1625s78.

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