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Aravind Asokan, PhD

Director of Gene Therapy
Professor in Surgery
Professor of Molecular Genetics and Microbiology
Campus Mail: DUMC 3 Genome Court, Msrb3, 5148, Box 2653, Duke Surgery, Durham, NC 27710

Synthetic Virology & Gene Therapy

Education and Training

  • Ph.D., University of North Carolina - Chapel Hill, 2004

Publications

Horowitz, Eric D., K Shefaet Rahman, Brian D. Bower, David J. Dismuke, Michael R. Falvo, Jack D. Griffith, Stephen C. Harvey, and Aravind Asokan. “Biophysical and ultrastructural characterization of adeno-associated virus capsid uncoating and genome release.” J Virol 87, no. 6 (March 2013): 2994–3002. https://doi.org/10.1128/JVI.03017-12.

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Shen, Shen, Kelli D. Bryant, Junjiang Sun, Sarah M. Brown, Andrew Troupes, Nagesh Pulicherla, and Aravind Asokan. “Glycan binding avidity determines the systemic fate of adeno-associated virus type 9.” J Virol 86, no. 19 (October 2012): 10408–17. https://doi.org/10.1128/JVI.01155-12.

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Denard, Jerome, Cyriaque Beley, Robert Kotin, Rene Lai-Kuen, Stephane Blot, Herve Leh, Aravind Asokan, et al. “Human galectin 3 binding protein interacts with recombinant adeno-associated virus type 6.” In Human Gene Therapy, 23:A122–A122. MARY ANN LIEBERT INC, 2012.

Scholars@Duke

Li, Chengwen, Nina Diprimio, Dawn E. Bowles, Matthew L. Hirsch, Paul E. Monahan, Aravind Asokan, Joseph Rabinowitz, Mavis Agbandje-McKenna, and R Jude Samulski. “Single amino acid modification of adeno-associated virus capsid changes transduction and humoral immune profiles.” J Virol 86, no. 15 (August 2012): 7752–59. https://doi.org/10.1128/JVI.00675-12.

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Horowitz, Eric D., M. G. Finn, and Aravind Asokan. “Tyrosine cross-linking reveals interfacial dynamics in adeno-associated viral capsids during infection.” Acs Chem Biol 7, no. 6 (June 15, 2012): 1059–66. https://doi.org/10.1021/cb3000265.

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Denard, Jerome, Cyriaque Beley, Robert Kotin, René Lai-Kuen, Stéphane Blot, Hervé Leh, Aravind Asokan, et al. “Human galectin 3 binding protein interacts with recombinant adeno-associated virus type 6.” J Virol 86, no. 12 (June 2012): 6620–31. https://doi.org/10.1128/JVI.00297-12.

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Shen, Shen, Junjiang Sun, Matthew Hirsch, Sai Chavala, Paul Monahan, and Aravind Asokan. “Altering Tissue Glycan Patterns Improves the Transduction Profile of AAV9 Vectors.” In Molecular Therapy, 20:S203–S203. NATURE PUBLISHING GROUP, 2012.

Scholars@Duke

Horowitz, Eric D., and Aravind Asokan. “Vector Genome Length and Self-Complementarity Affect AAV Capsid Uncoating.” In Molecular Therapy, 20:S202–S202. NATURE PUBLISHING GROUP, 2012.

Scholars@Duke

Li, C., N. Narkbunnam, R. J. Samulski, A. Asokan, G. Hu, L. J. Jacobson, M. J. Manco-Johnson, P. E. Monahan, and P. E. Joint Outcome Study Investigators. “Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia.” Gene Ther 19, no. 3 (March 2012): 288–94. https://doi.org/10.1038/gt.2011.90.

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